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公开(公告)号:CA2876296A1
公开(公告)日:2014-01-09
申请号:CA2876296
申请日:2013-07-04
Applicant: STICHTING VU VUMC
Inventor: CHRISTIAANS JOHANNES ANTONIUS MARIA , WINDHORST ALBERT DIRK , METAXAS ATHANASIOS , KLEIN PIETER JACOB , KOOIJMAN ESTHER JOHANNA MARIA , VAN BERCKEL BART NICOLAAS MARIA
IPC: C07C217/56 , C07D213/24
Abstract: The invention is directed to a compound according to formula (1) wherein R2 is fluorine, X is nitrogen or carbon and R3 is an organic group. The invention is also directed to the use of this compound as a precursor for the preparation of a11C or18F-radio labelled compound. The radio labelled compound may be used in an in vivo diagnostic or imaging method.
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公开(公告)号:NL2009131C2
公开(公告)日:2014-01-07
申请号:NL2009131
申请日:2012-07-05
Applicant: STICHTING VU VUMC
Inventor: CHRISTIAANS JOHANNES ANTONIUS MARIA , WINDHORST ALBERT DIRK , METAXAS ATHANASIOS , KLEIN PIETER JACOB , KOOIJMAN ESTHER JOHANNA MARIA , BERCKEL BART NICOLAAS MARIA
IPC: C07C217/56 , C07D213/24
Abstract: The invention is directed to a compound according to formula (1) wherein R2 is fluorine, X is nitrogen or carbon and R3 is an organic group. The invention is also directed to the use of this compound as a precursor for the preparation of a 11C or 18F-radio labelled compound. The radio labelled compound may be used in an in vivo diagnostic or imaging method.
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公开(公告)号:NL2008873C2
公开(公告)日:2013-11-26
申请号:NL2008873
申请日:2012-05-24
Applicant: STICHTING VU VUMC
Inventor: MANGEOL PIERRE , PETERMAN ERWIN
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公开(公告)号:AU2012231884A1
公开(公告)日:2013-10-10
申请号:AU2012231884
申请日:2012-01-16
Applicant: STICHTING VU VUMC , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Inventor: WURDINGER THOMAS , NILSSON ROLF JONAS
IPC: G01N33/48
Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.
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公开(公告)号:NL2008608C2
公开(公告)日:2013-10-09
申请号:NL2008608
申请日:2012-04-05
Applicant: STICHTING VU VUMC
Inventor: ROELOFS THEODORUS FRANK MARIA , STRAALEN NICOLAAS MARIA
IPC: C12Q1/68
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公开(公告)号:CA2855969A1
公开(公告)日:2013-06-27
申请号:CA2855969
申请日:2012-11-16
Applicant: STICHTING VU VUMC
IPC: A61B17/04
Abstract: The invention relates to a suture device, comprising a needle operating device and an elongate housing, wherein the needle operating device is movable in a longitudinal direction with respect to the housing between at least an insertion position and a needle transfer position, wherein the needle operating device comprises: an elongate operating element arranged or to be arranged extending from a distal end of the housing to or near a proximal end of the housing; a needle holder connected at a distal end of the operating element to hold two or more needles, such that the free ends of the needles are directed in proximal direction of the suture device; and a needle protection device, wherein the needle holder is at least partially movably with respect to the needle protection device between at least a protecting position wherein at least the free ends ofthe needles held by the needle holder are shielded by the needle protection device, and a non-protecting position wherein the free ends of the needles non- shielded by the needle protection device, wherein the housing comprises a needle receive device arranged at a distal end of the housing to receive the free ends of the needles when the needle operating device is moved from the insertion position to the needle transfer position, and wherein in at least the insertion position of the needle operating device the needle holder and the needle protection device are spaced from the housing in the longitudinal direction to receive a tissue to be sutured therebetween.
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公开(公告)号:AU2011277178A2
公开(公告)日:2013-02-07
申请号:AU2011277178
申请日:2011-07-15
Applicant: STICHTING VU VUMC
Inventor: WURDINGER THOMAS , NILSSON ROLF JONAS
IPC: G01N33/48
Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.
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118.
公开(公告)号:CA2839838A1
公开(公告)日:2013-01-10
申请号:CA2839838
申请日:2012-07-04
Applicant: STICHTING VU VUMC , VEENHOF MEDICAL DEVICES B V
Abstract: The invention relates to a system for predicting the viability of a body tissue in a patient. The system comprises a computing device (1), and a first pressure measuring device (2) for measuring local perfusion pressure in the body tissue of the patient. This measuring device is connected to the computing device. A second pressure measuring device (5) is provided for measuring the systemic perfusion pressure of the patient, said second pressure measuring device being connected to the computing device. A feedback indicator (6) is connected to the computing device and is adapted to indicate the viability of the tissue calculated by the computing device on the basis of the measured local and systemic perfusion pressures. The invention also includes a method of predicting the viability of the body tissue and to the first pressure measuring device.
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公开(公告)号:CA2855969C
公开(公告)日:2021-01-19
申请号:CA2855969
申请日:2012-11-16
Applicant: STICHTING VU VUMC
IPC: A61B17/04
Abstract: The invention relates to a suture device, comprising a needle operating device and an elongate housing, wherein the needle operating device is movable in a longitudinal direction with respect to the housing between at least an insertion position and a needle transfer position, wherein the needle operating device comprises: an elongate operating element arranged or to be arranged extending from a distal end of the housing to or near a proximal end of the housing; a needle holder connected at a distal end of the operating element to hold two or more needles, such that the free ends of the needles are directed in proximal direction of the suture device; and a needle protection device, wherein the needle holder is at least partially movably with respect to the needle protection device between at least a protecting position wherein at least the free ends ofthe needles held by the needle holder are shielded by the needle protection device, and a non-protecting position wherein the free ends of the needles non- shielded by the needle protection device, wherein the housing comprises a needle receive device arranged at a distal end of the housing to receive the free ends of the needles when the needle operating device is moved from the insertion position to the needle transfer position, and wherein in at least the insertion position of the needle operating device the needle holder and the needle protection device are spaced from the housing in the longitudinal direction to receive a tissue to be sutured therebetween.
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公开(公告)号:GB202013208D0
公开(公告)日:2020-10-07
申请号:GB202013208
申请日:2020-08-24
Applicant: STICHTING VU VUMC
Abstract: There is provided a spectroscopy apparatus for measuring fluorescence signals from a photosynthetic object. The spectroscopy apparatus comprises: one or more light excitation sources (26,28) operable to carry out time- varying excitation of the fluorescence from the photosynthetic object; and one or more fluorescence-sensitive detection channels (36,38,44,46) configured to simultaneously record the fluorescence as a function of time with a microsecond to millisecond time resolution and as a function of wavelength with a wavelength resolution of 10 nm or better, responsive to the excitation of the fluorescence from the photosynthetic object by the or each light excitation source (26,28).
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