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    VERAPAMIL LIKE COMPOUNDS
    3.
    发明申请
    VERAPAMIL LIKE COMPOUNDS 审中-公开
    VERAPAMIL类化合物

    公开(公告)号：WO2014098593A1

    公开(公告)日：2014-06-26

    申请号：PCT/NL2013050925

    申请日：2013-12-19

    Applicant: STICHTING TECH WETENSCHAPP ,  STICHTING VU VUMC ,  UNIV GRONINGEN ,  GRONINGEN ACAD ZIEKENHUIS

    Inventor： RAAPHORST RENSKE ,  LUURTSEMA GERT ,  WINDHORST ALBERT DIRK ,  LAMMERTSMA ADRIAAN

    IPC: A61K51/04 ,  A61K31/277 ,  C07B59/00

    CPC classification number: A61K31/277 ,  A61K51/04 ,  C07B59/001

    Abstract: The invention is directed to a compound, a salt or a solvate thereof according to (I) wherein R1 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group, R2, R3, R4 and R5 are eacn independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein R1 is a methyl group, and R3 is a R3 is a fluoroalkyl group or a [18F]fluoroalkyl group, R2, R4 and R5 are each independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein if R1 is hydrogen, at least one of R2, R3, R4 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group.

    Abstract translation: 本发明涉及根据（I）的化合物，其盐或溶剂合物，其中R 1是任选支链的氟代烷基或[18 F]氟代烷基，R 2，R 3，R 4和R 5独立地是甲基，[3 H] 甲基，氟代烷基或[18 F]氟烷基，R 6为（R） - 氰基或（S） - 氰基; 或其中R 1为甲基，R 3为R 3为氟烷基或[18 F]氟代烷基，R 2，R 4和R 5各自独立地为甲基，[3 H]甲基，氟代烷基或[18 F]氟代烷基，和 R6是（R） - 氰基或（S） - 氰基; 或其中如果R 1是氢，则R 2，R 3，R 4中的至少一个是任选支链的氟代烷基或[18 F]氟代烷基。

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