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    Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines
    115.
    发明公开
    Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines 审中-公开
    Tumorassoziiertes Antigen，Peptide davon，und deren Verwendung als Antitumorimpfstoffe

    公开(公告)号：EP2181595A1

    公开(公告)日：2010-05-05

    申请号：EP09177237.6

    申请日：2003-07-28

    Applicant: Yeda Research And Development Company Ltd.

    Inventor： Eisenbach, Lea ,  Tirosh, Boaz ,  Carmon, Lior ,  Machlenkin, Arthur ,  Paz, Adrian ,  Tzehoval, Esther ,  Fridkin, Matityahu

    IPC: A01N37/18 ,  A61K35/00 ,  A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/00

    CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/723

    Abstract: The invention relates to colon and prostate tumor associated antigen peptides obtainable from prostate specific G protein-coupled receptor (PSGR), six-transmembrane epithelial antigen of prostate (STEAP) and proteins encoded by genes found overexpressed in colon carcinoma cells, such as human 1-8D interferon induced transmembrane protein 2. The invention further relates to a polynucleotide encoding the tumor associated antigen peptides and to pharmaceutical compositions, which are preferably anti-tumor vaccine compositions, containing a tumor associated antigen, at least one tumor associated antigen peptide thereof, or encoding polynucleotide thereof as an active ingredient. The pharmaceutical compositions can be administered to a patient in need thereof to treat or inhibit the development of colon or prostate cancer.

    Abstract translation: 本发明涉及可从前列腺特异性G蛋白偶联受体（PSGR）获得的结肠和前列腺肿瘤相关抗原肽，前列腺的六跨膜上皮抗原（STEAP）和由结肠癌细胞中过表达的基因编码的蛋白质，例如人1 -8D干扰素诱导的跨膜蛋白2.本发明还涉及编码肿瘤相关抗原肽和药物组合物的多核苷酸，其优选为抗肿瘤疫苗组合物，其含有肿瘤相关抗原，至少一种肿瘤相关抗原肽， 或其编码多核苷酸作为活性成分。 药物组合物可以施用于有需要的患者以治疗或抑制结肠或前列腺癌的发展。

    ANIMAL MODEL FOR HEPATITIS VIRUS INFECTION
    117.
    发明授权
    ANIMAL MODEL FOR HEPATITIS VIRUS INFECTION 失效
    动物模型肝炎病毒INFECTION-

    公开(公告)号：EP0699235B1

    公开(公告)日：2007-05-09

    申请号：EP94917988.1

    申请日：1994-05-13

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

    Inventor： REISNER, Yair

    IPC: C12N15/00

    CPC classification number: A61K35/28 ,  A01K67/0271 ,  A61K35/38 ,  A61K35/407 ,  C07K16/109

    Abstract: A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.

    ANTIGEN-PRESENTING CELLS FOR NEUROPROTECTION AND NERVE REGENERATION
    119.
    发明公开
    ANTIGEN-PRESENTING CELLS FOR NEUROPROTECTION AND NERVE REGENERATION 审中-公开
    抗原提呈细胞的保护和神经再生NEURO

    公开(公告)号：EP1578199A2

    公开(公告)日：2005-09-28

    申请号：EP03760117.6

    申请日：2003-06-12

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

    Inventor： EISENBACH-SCHWARTZ, Michal ,  COHEN, Avraham

    IPC: A01N63/00

    CPC classification number: A61K39/0007 ,  A61K2039/5154

    Abstract: Pharmaceutical compositions and methods for preventing or inhibiting neuronal degeneration, or for promoting nerve regeneration, in the central nervous system (CNS) or peripheral nervous system (PNS), in the treatment of an injury, disorder or disease of the CNS or PNS, comprise antigen-presenting cells, preferably dendritic cells, that have been pulsed with an agent selected from the group consisting of: (a) a nervous system (NS)-specific antigen or an analog thereof; (b) a peptide derived from an NS-specific antigen or from an analog thereof, or an analog or derivative of said peptide; (c) a copolymer selected from the group consisting of Copolymer 1, a Copolymer 1-related peptide or polypeptide, and poly-Glu Tyr ; and (d) a non-self antigen.

    2,3-DIOXABICYCLO 3.3.1]NONANE DERIVATIVES AND ANTIMALARIAL PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
    120.
    发明授权
    2,3-DIOXABICYCLO 3.3.1]NONANE DERIVATIVES AND ANTIMALARIAL PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权
    2,3-二氧杂双环[3.3.1]壬烷衍生物及含有抗疟疾药物组合物

    公开(公告)号：EP1021403B1

    公开(公告)日：2005-04-20

    申请号：EP98942990.7

    申请日：1998-09-10

    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  JOHNS HOPKINS UNIVERSITY

    Inventor： BACHI, Mario ,  POSNER, Gary, H. ,  KORSHIN, Edward

    IPC: C07D201/00

    CPC classification number: C07D319/02

    Abstract: 2,3-Dioxabicyclo[3.3.1]nonane derivatives, carrying, at position 4, a sulfur-containing functionality selected from the group consisting of sulfonyl, sulfinyl and sulfenyl, adhered to C(4) via methylene group, represented by structural formula (A) wherein: X is hydrogen, hydroxy, alkoxy, optionally substituted by alkoxy or acyloxy, aralkoxy or acyloxy optionally substitued by alkoxy or aryloxy, and M is hydrogen, hydroxy, alkoxy, alkenyloxy, acyloxy, optionally substituted by acyl or acyloxy, aralkoxy, arylalkenyloxy, oxalyloxy substitued by alkoxy, di(alkyl)amino or alkyl(aryl)amino, di(aralalkyl)amino or carbonyloxy substituted by aryloxy, di(alkyl)amino, di(aralkyl)amino and alkyl(aryl)amino; or X and M together represent a carbon-carbon bond or an oxygen atom; L is hydrogen or L and M together represent a carbon-carbon bond; and either Z is a radical R-S(=O)n- and Y is hydrogen, or Y is R-S(=O)n- and Z is hydrogen, wherein R is alkyl optionally substituted by alkoxy or alkoxycarbonyl, cycloalkyl, or aryl or araklkyl optionally substituted by alkyl, halogen or CF3; and n is 0, 1 or 2, are useful for the prevention and/or treatment of malaria.

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