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公开(公告)号：KR1020110138168A
公开(公告)日：2011-12-26
申请号：KR1020110057478
申请日：2011-06-14
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/347 , A61K8/31 , A61K8/34 , A61K8/37 , A61K8/97 , A61K36/60 , A61K2236/00 , A61Q19/02 , C07C29/86 , C07C37/004 , A61Q19/00 , C07C39/21
Abstract: PURPOSE: A method for isolating Broussonetia kazinoki extract is provided to ensure excellent skin whitening and high stability. CONSTITUTION: A method for preparing Broussonetia kazinoki extract comprises: a step of isolating Broussonetia kazinoki with a solvent at 50-100°C for 1-10 hours; a step of placing Broussonetia kazinoki extract at -5 to 25°C for 1-40 hours; and a step of crystallizing the Broussonetia kazinoki. The solvent is alcohol. The method further comprises a step of supporting the Broussonetia kazinoki extract in a carrier. The Broussonetia kazinoki extract is contained in 0.01-30 wt% based on the carrier. The method also comprises a step of using HSCCC(High speed counter current chromatography) of two phase solvents to prepare a skin whitening active ingredient, kazinol C.
Abstract translation: 目的：提供分离布鲁氏菌提取物的方法，以确保优异的皮肤美白和高稳定性。 构成：制备布鲁氏菌提取物的方法包括：用溶剂在50-100℃下将布鲁氏菌分离1-10小时的步骤; 将布鲁诺氏菌提取物在-5至25℃下放置1-40小时的步骤; 并且使得Broussonetia kazinoki结晶的步骤。 溶剂是醇。 该方法还包括在载体中支持布鲁氏菌提取物的步骤。 布鲁氏菌提取物含量为0.01-30重量％，基于载体。 该方法还包括使用两相溶剂的HSCCC（高速逆流色谱）来制备皮肤美白活性成分，kazinol C.
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112.发明授权카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含有组织蛋白酶G的皮肤的组合物用于防止皮肤老化和筛选用于开发抗衰老材料的方法
公开(公告)号：KR100937263B1
公开(公告)日：2010-01-15
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: 본 발명은 노화된 피부에서 많이 생성되는 피부 부착단백질의 분해 산물들이 피부세포에서 콜라겐 분해 효소인 메탈로프로티아제(metalloprotease)의 발현을 증가시키는 사실로부터 부착단백질의 분해 억제를 통해 메탈로프로티아제의 발현을 막을 수 있는 카텝신 G 저해제를 함유하는 피부노화 방지용 피부외용제 조성물 및 상기 카텝신 G 저해제, 즉 항노화 물질을 개발하기 위한 스크리닝 방법에 대한 것으로서, 피부세포의 부착력 증가 및 부착 단백질의 분해억제를 통해 메탈로프로티아제의 발현과 활성을 막아 피부노화 방지, 피부 주름살 증가 억제, 탄력성 증가 및 피부 처짐 방지 개선물질 개발을 할 수 있는 새로운 스크리닝 방법의 개발에 관한 것이다.
부착단백질*파이브로넥틴*카텝신 G*주름개선*탄력개선*피부처짐*피부노화-
Patent Agency Ranking
公开(公告)号：KR1020090130801A
公开(公告)日：2009-12-24
申请号：KR1020080124479
申请日：2008-12-09
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A skin external composition containing ginseng seed oil or ginseng seed skin extract is provided to ensure skin improvement effect without side effects. CONSTITUTION: A skin external composition contains ginseng seed extract as an active ingredient. The ginseng seed extract is 0.001-100 weight% of ginseng seed oil or 0.001-10 weight% of ginseng seed skin extract. A method for extracting ginseng seed skin comprises: a step of pulverizing dried ginseng seed and placing the ginseng seed at room temperature in hexane organic solvent to remove oil from the ginseng seed; a step of placing the remaining ginseng seed skin in organic solvent containing water or organic solvent at room temperature; and a step of filtering extract and concentrating.
Abstract translation: 目的：提供含有人参种子油或人参种子皮肤提取物的皮肤外用组合物，以确保皮肤改善效果而没有副作用。 构成：皮肤外用组合物含有人参种子提取物作为活性成分。 人参种子提取物为人参种子油的0.001-100重量％或人参种子皮肤提取物的0.001-10重量％。 一种提取人参种子皮的方法包括：将干燥人参种子粉碎并将人参种子在室温下放置在己烷有机溶剂中以从人参种子中除去油的步骤; 在室温下将剩余的人参种子皮肤置于含水或有机溶剂的有机溶剂中的步骤; 以及过滤提取和浓缩的步骤。
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公开(公告)号：KR1020090011226A
公开(公告)日：2009-02-02
申请号：KR1020070074602
申请日：2007-07-25
Applicant: (주)아모레퍼시픽
Abstract: A composition for skin external application containing green tea flower essential oil is provided to protect skin cell, to improve wrinkle, to suppress deterioration of skin elasticity and pigmentation and to remove active oxygen species. A composition for skin external application comprises green tea flower essential oil to active ingredient. The green tea flower essential oil is a green tea fragrance component obtained through a steam distillation after extracting a solvent of the green tea flower. The green tea flower fragrance component contains 4,8-dimethyl-1,3(E), 7-nonatriene and Syringa vulgaris alcohol.
Abstract translation: 提供含有绿茶花精油的皮肤外用组合物，以保护皮肤细胞，改善皱纹，抑制皮肤弹性和色素沉淀的恶化和除去活性氧。 用于皮肤外用的组合物包括绿茶花精油为活性成分。 绿茶花精油是在提取绿茶花溶剂后通过蒸汽蒸馏获得的绿茶香精成分。 绿茶花香味成分含有4,8-二甲基-1,3（E），7-壬三烯和寻常and酒。
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公开(公告)号：KR1020080101419A
公开(公告)日：2008-11-21
申请号：KR1020070048493
申请日：2007-05-18
Applicant: (주)아모레퍼시픽
Abstract: A composition for external application for skin is provided to remove an active oxygen species(ROS) generated by an ultraviolet ray by containing green tea flower extracts, to protect skin cell by controlling minute inflammations generated by an outside stimulus, to delay skin aging, to suppress generation of wrinkle and deterioration of skin elasticity and to reduce pigmentation. A composition for external application for skin contains green tea flower extracts. The green tea flower extracts contains a fragrance component of the green tea flower which is a green tea flower essential oil containing an E-4,8-dimethyl-1,3,7-nonatriene and a lilac alcohol. The composition for skin external application is selected from a group consisting of Epigallocatechin gallate, gallocatechin gallate, catechin gallate, Theanine, kaempferol, green tea catechin extracts and a green tea extract.
Abstract translation: 提供外用于皮肤的组合物，以通过含有绿茶花提取物除去由紫外线产生的活性氧（ROS），通过控制由外部刺激产生的微小的炎症，延缓皮肤老化来保护皮肤细胞，延缓皮肤老化 抑制皱纹的产生和皮肤弹性的恶化，减少色素沉着。 外用皮肤组合物含有绿茶花提取物。 绿茶花提取物含有绿茶花的香味成分，它是含有E-4,8-二甲基-1,3,7-壬三烯和丁香醇的绿茶花精油。 皮肤外用组合物选自表没食子儿茶素没食子酸，没食子儿茶素没食子酸酯，儿茶素没食子酸酯，茶氨酸，山奈酚，绿茶儿茶素提取物和绿茶提取物。
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公开(公告)号：KR1020080094540A
公开(公告)日：2008-10-23
申请号：KR1020070100233
申请日：2007-10-05
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K36/258 , A61Q19/08
Abstract: A skin external application composition comprising an extract of ginseng fruits is provided to promote collagen generation and show MMP-1 inhibitory effect, anti-oxidative effect and DNA damage protecting effect, thereby capable of inhibiting skin aging and improving wrinkles. A skin external application composition comprises an extract of ginseng fruits, wherein the extract is prepared by drying flesh and pericarp of the ginseng fruits obtained by removing seeds from the fruits in the sun or hot-air drying the flesh and pericarp and then extracting the dried flesh and pericarp with water or ethanol.
Abstract translation: 提供包含人参果实提取物的皮肤外用施用组合物，以促进胶原产生，显示MMP-1抑制作用，抗氧化作用和DNA损伤保护作用，从而能够抑制皮肤老化和改善皱纹。 皮肤外用施用组合物包含人参果实提取物，其中所述提取物是通过干燥通过从太阳中从果实中除去种子而获得的人参果实的肉质和果皮，或热空气干燥肉和果皮，然后提取干燥的 肉和果皮用水或乙醇。
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公开(公告)号：KR1020060034007A
公开(公告)日：2006-04-21
申请号：KR1020040083124
申请日：2004-10-18
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 유효성분으로 연꽃(
Nelumbo nucifera )의 수술추출물(이하, '연수추출물'이라 함)을 함유하거나 상기 연수 추출물에 손바닥 선인장 추출물을 더 함유하는 피부외용제 조성물에 관한 것이다. 보다 상세히 설명하면, 본 발명의 피부외용제 조성물은 유효성분으로 연수 추출물을 함유하거나 상기 연수 추출물에 손바닥 선인장 추출물을 더 함유함으로써, 엘라스타아제 활성 저해 및 파이브로넥틴 분해 억제를 나타내고, 또한 우수한 피부처짐 방지효과를 나타낸다.
연수추출물 * 손바닥선인장추출물 * 엘라스타아제 * 탄력개선 * 피부처짐 * 파이브로넥틴
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