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公开(公告)号：WO2012057473A2
公开(公告)日：2012-05-03
申请号：PCT/KR2011/007878
申请日：2011-10-21
CPC classification number: C12Q1/025 , C12N5/0698 , G01N33/5044
Abstract: 본 발명은 실제 진피와 유사한 구조를 가지는 진피 모사체를 제작하여 진피 모사체의 변형 정도 차이를 3차원으로 시각화하여 나타냄으로써 피부 탄력 증진 효능을 평가하는 방법에 관한 것이다.
Abstract translation: 本发明涉及通过制备具有与真皮真皮相似的结构的模拟真皮来评价皮肤弹性的改善的方法，以及提供模拟真皮的转化程度的差异的三维可视化。
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公开(公告)号：KR1020100060780A
公开(公告)日：2010-06-07
申请号：KR1020080119520
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition which enhances skin rebirth is provided to enhance cell activation and to improve anti-wrinkle and elasticity. CONSTITUTION: A skin cosmetic composition contains 0.1-10 weight% of octacosanol and 0.1-30 weight% of Lepidium meyenii extract as an active ingredient. The octacosanol and Lepidium meyenii extract is mixed in a weight ratio of 1-9:9-1. The Lepidium meyenii extract is isolated using ethanol. The cosmetic composition is used in the form of skin, lotion, massage cream, nutrition cream, pack, gel, or ointment, patch, or spray.
Abstract translation: 目的：提供增强皮肤重生的化妆品组合物，以增强细胞活化和改善抗皱和弹性。 构成：皮肤化妆品组合物含有0.1-10重量％的二十八烷醇和0.1-30重量％的梅毒提取物作为活性成分。 二十八烷醇和梅毒提取物以1-9：9-1的重量比混合。 使用乙醇分离梅毒提取物。 化妆品组合物以皮肤，洗剂，按摩霜，营养霜，包装，凝胶或软膏，贴剂或喷雾剂的形式使用。
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公开(公告)号：KR1020080011543A
公开(公告)日：2008-02-05
申请号：KR1020060071985
申请日：2006-07-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/35 , A61K8/36 , A61K8/466 , A61K2800/78 , A61Q19/08
Abstract: A cosmetic composition is provided to promote collagen biosynthesis by comprising alpha-ketoglutarate increasing the prolidase activity involving with the supply of proline, a main constituent amino acid of the collagen, together with alpha-lipoic acid increasing the expression of prolyl-4-hydroxylase to make a generated pro-collagen form a right triple helix. A cosmetic composition for improving skin wrinkle comprises 0.001-10 wt.% of alpha-ketoglutarate as an effective ingredient. The composition further comprises 0.001-10 wt.% of alpha-lipoic acid.
Abstract translation: 提供化妆品组合物以通过包含α-酮戊二酸来增加胶原蛋白生物合成，所述α-酮戊二酸增加脯氨酸酶活性，其涉及脯氨酸的供应，胶原的主要成分氨基酸与α-硫辛酸一起增加脯氨酰-4-羟化酶的表达， 使生成的原胶原形成右三重螺旋。 用于改善皮肤皱纹的化妆品组合物包含0.001-10重量％的作为有效成分的α-酮戊二酸。 组合物还包含0.001-10重量％的α-硫辛酸。
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4.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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公开(公告)号：KR101219294B1
公开(公告)日：2013-01-08
申请号：KR1020060071985
申请日：2006-07-31
Applicant: (주)아모레퍼시픽
Abstract: 본발명은α-케토글루타레이트(α-ketoglutarate)를함유하는주름개선용화장료조성물에관한것으로, 보다상세하게는α-케토글루타레이트가콜라겐의주요구성아미노산인프롤린의공급에관여하는프롤리다아제활성을증가시킴으로써콜라겐생성을촉진시키는주름개선용화장료조성물에관한것이다. 또한, 본발명에의한화장료조성물은상기α-케토글루타레이트와함께α-리포익산(α-lipoic acid)을유효성분으로더 함유할수 있으며, 상기α-리포익산은프롤릴-4-수산화효소발현을증가시켜생성된프로콜라겐이올바른삼중나선(triple helix)을형성시키는역할을한다. 즉, 본발명에의한화장료조성물은프롤리다아제활성을증가시키는α-케토글루타레이트와함께α-리포익산을함유함으로써콜라겐생합성을촉진시킨다.
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Patent Agency Ranking
公开(公告)号：KR101739330B1
公开(公告)日：2017-05-24
申请号：KR1020100107001
申请日：2010-10-29
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/025 , C12N5/0698 , G01N33/5044
Abstract: 본발명은실제진피와유사한구조를가지는진피모사체를제작하여진피모사체의변형정도차이를 3차원으로시각화하여나타냄으로써피부탄력증진효능을평가하는방법에관한것이다.
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公开(公告)号：KR1020120058737A
公开(公告)日：2012-06-08
申请号：KR1020100120161
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/9706 , A61Q19/08
Abstract: PURPOSE: A cosmetic composition containing red algae is provided to regenerate epidermis and dermis on the skin and to improve anti-wrinkling with high safety. CONSTITUTION: A cosmetic composition for anti-aging contains 0.0001-25 wt% of red algae extract as an active ingredient. The red algae include Gelidium amansii, Gracilaria, gigartina, laver, Acanthopeltis japonica, gracilaria, Ceramium kondoi graphite or Grateloupia Filicina. The cosmetic composition is manufactured in the form of an emulsion, suspension, microemulsion, microcapsule, microgranule, or vesicle dispersion agent of ion type(liposome) and non-ion type.
Abstract translation: 目的：提供含有红藻的化妆品组合物，以再生皮肤上的表皮和真皮，并以高安全性改善抗皱纹。 构成：抗衰老化妆品组合物含有0.0001〜25重量％的红藻提取物作为活性成分。 红藻包括Gel include ii，江ia，g ina，紫菜，j ica，gr ia，ium oi石或花岗丝or。 化妆品组合物以离子型（脂质体）和非离子型的乳液，悬浮液，微乳液，微胶囊，微粒或囊泡分散剂的形式制造。
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公开(公告)号：KR1020120048727A
公开(公告)日：2012-05-16
申请号：KR1020100107001
申请日：2010-10-29
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/025 , C12N5/0698 , G01N33/5044 , C40B30/00 , C40B30/02 , G01N33/15
Abstract: PURPOSE: A method for evaluating skin elasticity enhancement using corium mimic is provided to observe binding force between fibroblast and collagenous fiber. CONSTITUTION: A method or evaluating skin elasticity enhancement using corium mimic comprises: a step of preparing a saccharification collagen control group and a saccharification experimental group; a step of mixing fibroblasts to the control and experimental groups each to prepare gel; a step of constructing three-dimensional form using a culture insert; a step of putting gel of the control and experimental groups inside the culture insert and culturing to prepare corium mimic; a step of imaging the shape of the mimic in a three-dimension; and a step of evaluating elasticity change from the image result.
Abstract translation: 目的：提供使用corium模拟物评估皮肤弹性增强的方法，以观察成纤维细胞和胶原纤维之间的结合力。 构成：使用corium模拟物的方法或评估皮肤弹性增强包括：制备糖化胶原对照组和糖化实验组的步骤; 将成纤维细胞与对照组和实验组混合以制备凝胶的步骤; 使用培养基构建三维形状的步骤; 将对照组和实验组的凝胶放入培养物插入物和培养物中制备ium模拟物的步骤; 在三维中成像模拟物的形状的步骤; 以及从图像结果评估弹性变化的步骤。
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9.发明公开이끼 추출물 또는 그 유효 성분인 뎁시돈 또는 뎁시돈유도체를 함유하는 항노화 피부 외용제 조성물 无效皮肤外用应用于包含MOSS，DEPSIDONE或DEPSIDONE衍生物的抗皱剂的组合物
公开(公告)号：KR1020090052096A
公开(公告)日：2009-05-25
申请号：KR1020070118635
申请日：2007-11-20
Applicant: (주)아모레퍼시픽
IPC: A61K36/10 , A61K31/352 , A61K8/97 , A61P17/00
CPC classification number: A61K8/97 , A61K36/10 , A61K2236/37 , A61Q17/04 , A61Q19/00 , A61Q19/08 , Y10S514/844
Abstract: 본 발명은 이끼 추출물 또는 그 활성성분인 뎁시돈(depsidone) 또는 뎁시돈 유도체(depsidone derivatives)를 유효성분으로 함유한 주름개선용 피부 외용제 조성물에 관한 것이다. 본 발명의 피부 외용제 조성물은 결체조직의 필수 구성성분인 콜라겐의 분해를 억제하는 이끼 추출물 또는 그 활성성분인 뎁시돈 또는 뎁시돈 유도체를 함유함으로써 피부주름개선 및 탄력개선을 통하여 궁극적으로 피부노화를 지연 또는 개선시킬 수 있다.
콜라겐, 이끼 추출물, Cladonia Stellaris, 뎁시돈, 크립토스틱티놀라이드, 스틱틱산, 노르스틱틱산, 매트릭스 메탈로프로테이나제1, 비활성형, 활성형, 카셉신 G(cathepsin G), 피부주름, 탄력-
公开(公告)号：KR101781556B1
公开(公告)日：2017-09-27
申请号：KR1020100120161
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
Abstract: 본발명은홍조류를유효성분으로함유하는화장료조성물에관한것으로, 보다상세하게는홍조류를함유함으로써표피및 진피층의피부재생을도와피부주름을예방하여피부주름개선효과가우수하며피부에대한안전성이높은항노화용화장료조성물에관한것이다.
Abstract translation: 本发明涉及含有红藻类作为活性成分的化妆品组合物，更具体地说，本发明涉及含有红藻类， 一种抗衰老化妆品组合物。
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