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    피부의 볼륨 증가 촉진용 조성물
    113.
    发明公开
    피부의 볼륨 증가 촉진용 조성물 无效
    用于促进皮肤体积的组合物

    公开(公告)号：KR1020140097095A

    公开(公告)日：2014-08-06

    申请号：KR1020140092563

    申请日：2014-07-22

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  송민정 ,  노민수 ,  이형호 ,  이상민 ,  양승하 ,  김한곤

    IPC: A61K36/49 ,  A61K36/898 ,  A61K36/537 ,  A61P17/00

    CPC classification number: A61K36/49 ,  A61K8/97 ,  A61K36/537 ,  A61K36/898 ,  A61Q19/08

    Abstract: The present invention relates to a composition for promoting the differentiation of human mesenchymal stem cells into adipocytes. More specifically, the present invention relates to a composition for cosmetics or plastic surgery which increases the sense of volume of specific body part by creating lipid droplets by comprising at least one species among Castaneae semen, Selaginella tamariscina, Aloe vera, Salvia miltiorrhiza, Mentha arvensis, Pinellia ternate, Triticum aestivum, Saururus chinensis, Polygala tenuifolia, and Gleditsia sinensis extracts as an active ingredient to promote the differentiation of human mesenchymal stem cells into adipocytes.

    Abstract translation: 本发明涉及促进人间充质干细胞向脂肪细胞分化的组合物。 更具体地说，本发明涉及一种用于化妆品或整容手术的组合物，其通过在蓖麻精，卷柏，芦荟，丹参中提取至少一种物质，通过产生脂滴来增加特定身体部位的体积感 ，Pinellia ternate，Triticum aestivum，Saururus chinensis，Polygala tenuifolia和Gleditsia sinensis提取物作为活性成分，促进人类间充质干细胞分化成脂肪细胞。

    피부 색소 침착 조절물질을 스크리닝하는 방법
    116.
    发明公开
    피부 색소 침착 조절물질을 스크리닝하는 방법 审中-实审
    用于调节皮肤颜色的材料的筛选方法

    公开(公告)号：KR1020130051353A

    公开(公告)日：2013-05-20

    申请号：KR1020110116647

    申请日：2011-11-09

    Applicant: (주)아모레퍼시픽

    Inventor： 최현정 ,  최현 ,  한지연 ,  박주열 ,  신동욱 ,  이태룡 ,  노민수 ,  김광미

    IPC: G01N33/68 ,  G01N33/15 ,  G01N33/53 ,  C12N15/115

    Abstract: PURPOSE: A method for screening a material which regulates skin pigmentation is provided to screen a material for regulating skin pigmentation, and to effectively treat hyperpigmentation or hypopigmentation by regulating intracellular and intercellular signal transduction faction and transcription factor. CONSTITUTION: A method for screening a material which regulates skin pigmentation comprises: a step of treating one or more gene selected from the group consisting of IFN gamma, IL4, IL17, IL6, STAT3, STAT6, JAK1, JAK2, and JAK3 with a candidate material; and a step of selecting a candidate material which enhances or reduces gene expression as a material which regulates skin pigmentation. A candidate material which enhances gene expression is selected as a useful material which possibly suppresses pigmentation. A candidate material which reduces gene expression is selected as a useful material which possibly enhances skin pigmentation. [Reference numerals] (AA) Comparative example; (BB) Example 1; (CC) Example 2; (DD) Example 3

    Abstract translation: 目的：提供一种筛选调节皮肤色素沉着的材料的方法，筛选调节皮肤色素沉着的材料，并通过调节细胞内和细胞间信号转导系和转录因子有效治疗色素沉着过度或色素沉着不足。 构成：筛选调节皮肤色素沉着的材料的方法包括：用候选物质治疗选自IFNγ，IL4，IL17，IL6，STAT3，STAT6，JAK1，JAK2和JAK3的一种或多种基因的步骤 材料; 以及选择增强或降低基因表达作为调节皮肤色素沉着的材料的候选物质的步骤。 选择增强基因表达的候选物质作为可能抑制色素沉着的有用材料。 选择减少基因表达的候选物质作为可能增强皮肤色素沉着的有用材料。 （附图标记）（AA）比较例; （BB）实施例1; （CC）实施例2; （DD）实施例3

    인간 중간엽줄기세포의 분화 촉진용 조성물
    118.
    发明公开
    인간 중간엽줄기세포의 분화 촉진용 조성물 无效
    促进人类间质干细胞分化的组合物

    公开(公告)号：KR1020120092754A

    公开(公告)日：2012-08-22

    申请号：KR1020110001219

    申请日：2011-01-06

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  노민수

    IPC: A61K36/287 ,  A61P17/00

    Abstract: PURPOSE: A composition for promoting differentiation from human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity ad to improve anti-wrinkling. CONSTITUTION: An external use skin composition for promoting adipocyte differentiation contains 0.0001-30 wt% of Chrysanthemi sibirici Herba extract as an active ingredient. The composition promotes the differentiation of human mesenchymal stem cells into adipocytes. A pharmaceutical composition for promoting adipocyte differentiation contains the extract as an active ingredient. The daily dose of the extract is 0.001mg/kg/day-2000mg/kg/day.

    Abstract translation: 目的：提供用于促进从人间充质干细胞分化成脂肪细胞的组合物，以增强皮肤体积和弹性，以改善抗皱纹。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的菊花西布提取物作为活性成分。 该组合物促进人间充质干细胞分化为脂肪细胞。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。 提取物的日剂量为0.001mg / kg /天-2000mg / kg /天。

    3차원 매트릭스
    119.
    发明公开
    3차원 매트릭스 审中-实审
    三维矩阵

    公开(公告)号：KR1020120059785A

    公开(公告)日：2012-06-11

    申请号：KR1020100121220

    申请日：2010-12-01

    Applicant: (주)아모레퍼시픽

    Inventor： 최현정 ,  한지연 ,  김광미 ,  노민수 ,  이태룡

    IPC: A61K38/39 ,  C07K14/78 ,  C07K16/18 ,  A61P35/00

    Abstract: PURPOSE: A composition for a three dimensional matrix containing collagen 4, laminin, nidogen, and proteoglycan is provided to study cancer mechanism or treatment. CONSTITUTION: A composition for a three dimensional matrix contains each 0.001-30wt% of collagen IV, liminin, nidogen, and proteoglycan in a proportion. The three dimensional matrix includes a matrix for suppressing cell division or cell dedifferentiation. The cell is human pigmentary skin cells. The three dimensional matrix is prepared using the composition.

    Abstract translation: 目的：提供含有胶原蛋白4，层粘连蛋白，核酸和蛋白多糖的三维基质组合物，用于研究癌症机制或治疗。 构成：用于三维基质的组合物以一定比例含有每种含量为0.001-30重量％的胶原蛋白IV，利宁肽，蛋白多糖和蛋白多糖。 三维矩阵包括用于抑制细胞分裂或细胞去分化的基质。 细胞是人类色素皮肤细胞。 使用组合物制备三维矩阵。

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