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    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트
    3.
    发明公开
    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트 有权
    用于预测敏感性皮肤和测试套件的生物标记

    公开(公告)号：KR1020140123034A

    公开(公告)日：2014-10-21

    申请号：KR1020140124120

    申请日：2014-09-18

    Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

    Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6844

    Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention contains one or more gene selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consisting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.

    Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物含有选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。

    뉴로코스메틱 피부 미용방법, 피부 미용 물질 스크리닝방법 및 피부 미용 물질
    4.
    发明公开
    뉴로코스메틱 피부 미용방법, 피부 미용 물질 스크리닝방법 및 피부 미용 물질 有权
    神经性皮肤护理方法，用于筛选皮肤化妆品的方法和皮肤化妆品

    公开(公告)号：KR1020100000391A

    公开(公告)日：2010-01-06

    申请号：KR1020080059872

    申请日：2008-06-24

    Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

    Inventor： 손의동 ,  최현정 ,  김혁 ,  정연수 ,  임경민 ,  김지현 ,  문성준 ,  박영호 ,  김한곤 ,  이영미 ,  정진호

    IPC: A61K8/97 ,  A61Q19/08 ,  A61Q19/00

    CPC classification number: A61K8/97 ,  A61Q19/08

    Abstract: PURPOSE: A method for screening a cosmetic material and cosmetic composition containing a material suppressing TRPV-1(transient receptor potential family V-1) are provided to select a target material which is effective in anti-aging and reduce skin irritation. CONSTITUTION: A material which suppresses activation of TRPV-1(transient receptor potential family V-1) contains extract isolated from one or more selected from Prunus mume Sieb. et Zucc., Pleuropterus multflorus, and Atractylodes japonica Koidxumi or Atractylodes ovate Koidzumi. A cosmetic composition contains 0.001-10 weight%, preferably 0.01-5 weight% of the extract. The cosmetic composition is used in the form of nutrition skin, massage cream, pack gel or lotion, ointment, cream, patch or spray.

    Abstract translation: 目的：提供一种筛选含有抑制TRPV-1（瞬时受体潜能家族V-1）的物质的美容材料和化妆品组合物的方法，以选择有效抗衰老和降低皮肤刺激性的目标材料。 构成：抑制TRPV-1（瞬时受体电位家族V-1）活化的物质含有从一种或多种选自杏仁酵母中分离的提取物。 等等，Pleuropterus multflorus和Atractylodes japonica Koidxumi或Atractylodes ovate Koidzumi。 化妆品组合物含有0.001-10重量％，优选0.01-5重量％的提取物。 化妆品组合物以营养皮肤，按摩膏，包装凝胶或洗剂，软膏，霜剂，贴剂或喷雾剂的形式使用。

    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트
    9.
    发明公开
    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트 有权
    민감성피부진단용바이오마커및이를이용한진단키트

    公开(公告)号：KR1020140123032A

    公开(公告)日：2014-10-21

    申请号：KR1020140124111

    申请日：2014-09-18

    Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

    Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6844 ,  C12Q1/6813

    Abstract: Disclosed is a biomarker having the amount of gene expression be specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention one or more gene selected from a group composed of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group composed of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.

    Abstract translation: 公开了对敏感性皮肤具有特异性增加或减少的基因表达量的生物标志物。 敏感性皮肤特异性生物标志物用于这种用于敏感性皮肤的诊断试剂盒和中枢刺激剂的筛选方法。 根据本发明的用于诊断敏感性皮肤的生物标志物选自由HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。

    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트
    10.
    发明公开
    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트 有权
    用于预测敏感性皮肤和测试套件的生物标记

    公开(公告)号：KR1020140118972A

    公开(公告)日：2014-10-08

    申请号：KR1020140124107

    申请日：2014-09-18

    Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

    Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6844 ,  C12Q1/6813

    Abstract: Disclosed is a biomarker by which the amount of gene expression is increased or the gene expression is inhibited specifically with respect to sensitive skin. The biomarker can be used for a kit for testing sensitive skin and a method for screening an agent for alleviating irritation. The test kit includes: a polynucleotide of a TNFRSF19 gene, one or more polynucleotides which are fragments of the polynucleotide of the TNFRSF19 gene and include 10 or more serial nucleotides, or a polynucleotide complementary to the polynucleotide stated earlier and fragments thereof; and a solid scaffold having the surface on which the polynucleotides are bound.

    Abstract translation: 公开了一种基因表达量增加或相对于敏感皮肤特异性抑制基因表达的生物标志物。 生物标志物可用于测试敏感性皮肤的试剂盒和用于筛选试剂以减轻刺激性的方法。 测试试剂盒包括：TNFRSF19基因的多核苷酸，一种或多种多核苷酸，其是TNFRSF19基因的多核苷酸的片段，并且包括10个或更多个序列核苷酸，或与前述多核苷酸互补的多核苷酸及其片段; 和具有结合多核苷酸的表面的固体支架。

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