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公开(公告)号：KR1020140123032A
公开(公告)日：2014-10-21
申请号：KR1020140124111
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker having the amount of gene expression be specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention one or more gene selected from a group composed of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group composed of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了对敏感性皮肤具有特异性增加或减少的基因表达量的生物标志物。 敏感性皮肤特异性生物标志物用于这种用于敏感性皮肤的诊断试剂盒和中枢刺激剂的筛选方法。 根据本发明的用于诊断敏感性皮肤的生物标志物选自由HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020140118972A
公开(公告)日：2014-10-08
申请号：KR1020140124107
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker by which the amount of gene expression is increased or the gene expression is inhibited specifically with respect to sensitive skin. The biomarker can be used for a kit for testing sensitive skin and a method for screening an agent for alleviating irritation. The test kit includes: a polynucleotide of a TNFRSF19 gene, one or more polynucleotides which are fragments of the polynucleotide of the TNFRSF19 gene and include 10 or more serial nucleotides, or a polynucleotide complementary to the polynucleotide stated earlier and fragments thereof; and a solid scaffold having the surface on which the polynucleotides are bound.
Abstract translation: 公开了一种基因表达量增加或相对于敏感皮肤特异性抑制基因表达的生物标志物。 生物标志物可用于测试敏感性皮肤的试剂盒和用于筛选试剂以减轻刺激性的方法。 测试试剂盒包括：TNFRSF19基因的多核苷酸，一种或多种多核苷酸，其是TNFRSF19基因的多核苷酸的片段，并且包括10个或更多个序列核苷酸，或与前述多核苷酸互补的多核苷酸及其片段; 和具有结合多核苷酸的表面的固体支架。
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公开(公告)号：KR101439472B1
公开(公告)日：2014-09-15
申请号：KR1020070123865
申请日：2007-11-30
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 서열번호: 1의 염기서열 중에서 선택된 활성 부위를 포함하는 프로모터; 상기 프로모터 및 리포터 유전자를 포함하는 벡터; 상기 벡터를 포함하는, 지방분해를 촉진하는 후보물질을 검색하기 위한 키트; 및 상기 벡터를 이용하여 지방분해를 촉진하는 후보물질을 검색하는 방법에 관한 것이다.
본 발명에서 제공되는 프로모터는 퍼록시좀 증식인자-활성화 수용체-감마(peroxisome proliferator-activated receptor-gamma, PPAR-γ)와 결합하여 멜라노코르틴 2 수용체 부속 단백질(melanocortin 2 receptor accessory protein, Mrap) 유전자의 발현을 증진시켜 부신피질자극 호르몬(Adrenocorticotropic hormone, ACTH)에 의한 지방 분해를 촉진하기 때문에, 상기 프로모터를 적절한 리포터 유전자와 융합시킨 벡터를 이용하면 지방 분해를 촉진하는 후보물질을 효과적으로 검색할 수 있으며, 이를 통해 얻어진 후보물질은 Mrap 유전자의 발현을 증진시켜 ACTH에 의한 지방 분해를 촉진하여, 비만 관련 질환을 치료 및 예방할 수 있다.-
公开(公告)号：KR1020140089505A
公开(公告)日：2014-07-15
申请号：KR1020140081131
申请日：2014-06-30
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: The present invention discloses a biomarker of which a gene expression level increases or decreases specifically with respect to sensitive skin. The biomarker specific to sensitive skin can be applied to a kit for identifying sensitive skin and a screening method of an irritation reliever. The biomarker for identifying sensitive skin includes one or more genes selected from a group constituted by HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A,FKBP5, PI3, PSPH, HORMAD1, SPRR2G and ACTR2.
Abstract translation: 本发明公开了相对于敏感性皮肤特异性地基因表达水平升高或降低的生物标志物。 敏感皮肤特异性的生物标志物可用于鉴定敏感皮肤的试剂盒和刺激缓解剂的筛选方法。 识别敏感皮肤的生物标志物包括选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A，FKBP5，PI3，PSPH组成的组中的一种或多种基因 ，HORMAD1，SPRR2G和ACTR2。
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公开(公告)号：KR1020140084808A
公开(公告)日：2014-07-07
申请号：KR1020120154702
申请日：2012-12-27
Applicant: (주)아모레퍼시픽
CPC classification number: A61K38/20 , A61K8/64 , A61K9/0014 , A61Q19/02
Abstract: The present invention relates to a composition for whitening the skin, wherein the composition contains interleukin 27 (IL-27). More specifically, the present invention relates to a skin external application composition containing IL-27 so as to control the chromogenesis of adult melanocytes in the skin so that the skin can be whitened and hyperchromatism including chloasma and lentigo can be treated.
Abstract translation: 本发明涉及一种用于使皮肤美白的组合物，其中该组合物含有白细胞介素27（IL-27）。 更具体地，本发明涉及含有IL-27的皮肤外用剂组合物，以控制皮肤中成人黑素细胞的发色，从而可以使皮肤发白，并可以治疗包括黄褐斑和雀斑的过度色素沉着。
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Patent Agency Ranking
公开(公告)号：KR1020140084806A
公开(公告)日：2014-07-07
申请号：KR1020120154700
申请日：2012-12-27
Applicant: (주)아모레퍼시픽
IPC: A61K31/4152 , A61K31/41 , A61K8/49 , A61P17/00
CPC classification number: A61K31/64 , A61K8/494 , A61K9/0014 , A61Q19/02
Abstract: The present invention relates to a skin external application composition containing SM-19712. More specifically, the skin external application composition exhibits excellent skin whitening effects by containing SM-19712, which is an antagonist of a substance P, as an active ingredient.
Abstract translation: 本发明涉及含有SM-19712的皮肤外用剂组合物。 更具体地，皮肤外用组合物通过含有作为P物质的拮抗剂的SM-19712作为活性成分，显示出优异的皮肤美白效果。
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公开(公告)号：KR1020140078973A
公开(公告)日：2014-06-26
申请号：KR1020120148356
申请日：2012-12-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K38/2086 , A61K8/64 , A61K9/0014 , A61Q19/02 , C07K14/5437
Abstract: The present invention relates to a skin whitening composition including interleukin 13 (IL-13), more specifically, to a skin preparation composition for an external use, wherein the composition comprises IL-13 to suppress a generation of a pigment and differentiation of an adult melanin cell on the skin, thereby providing a skin whitening effect; and is effective in curing hyperpigmentation skin diseases such as melasma or lentigo.
Abstract translation: 本发明涉及包含白细胞介素13（IL-13）的皮肤美白组合物，更具体地，涉及外用皮肤制剂组合物，其中所述组合物包含IL-13以抑制颜料的产生和成人的分化 皮肤上的黑色素细胞，从而提供皮肤美白效果; 并且有效地治疗色素沉着过度的皮肤疾病如黑斑病或雀斑斑。
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公开(公告)号：KR1020130140318A
公开(公告)日：2013-12-24
申请号：KR1020120063582
申请日：2012-06-14
Applicant: (주)아모레퍼시픽
Abstract: The present invention provides a composition for skin whitening which contains wortmannin as an active ingredient. The composition for skin whitening which contains wortmannin as an active ingredient according to the present invention whitens skin by reducing melanin production, suppressing tyrosinase activation and reducing expression of melanogenesis-related gene and protein and can be widely applied to skin externals, cosmetic compositions, and pharmaceutical compositions by having stability not to have bad influence on cells.
Abstract translation: 本发明提供了含有渥曼青霉素作为活性成分的皮肤美白组合物。 含有渥曼青霉素作为本发明活性成分的皮肤美白组合物通过减少黑色素产生，抑制酪氨酸酶活化和减少黑素生成相关基因和蛋白质的表达来增白皮肤，并可广泛应用于皮肤外用剂，化妆品组合物和 稳定性不会对细胞产生不良影响的药物组合物。
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公开(公告)号：KR1020130140317A
公开(公告)日：2013-12-24
申请号：KR1020120063581
申请日：2012-06-14
Applicant: (주)아모레퍼시픽
IPC: A61K8/49 , A61K31/5377 , A61Q19/02 , A61P17/00
CPC classification number: A61K8/498 , A61K31/5377 , A61Q19/02
Abstract: The present invention provides a composition containing LY294002 for skin whitening. The composition containing LY294002 for skin whitening reduces the generation of melanin, suppresses the activity of tyrosinase, and reduces the expression of genes and protein related to the generation of melanin for whitening the skin. The composition containing LY294002 for skin whitening has stability which does not have bad influence to cells, and is capable of widely applied to a skin external application, a cosmetic composition, and a pharmaceutical composition.
Abstract translation: 本发明提供含有LY294002用于皮肤美白的组合物。 含有LY294002用于皮肤美白的组合物减少黑色素的产生，抑制酪氨酸酶的活性，并减少与产生黑色素相关的基因和蛋白质的表达，以使皮肤美白。 含有用于皮肤美白的LY294002的组合物具有对细胞没有不良影响的稳定性，并且能够广泛地应用于皮肤外用剂，化妆品组合物和药物组合物。
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公开(公告)号：KR101327028B1
公开(公告)日：2013-11-13
申请号：KR1020070005217
申请日：2007-01-17
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 TCA회로에서 ATP 생성에 관여하는 아이소사이트레이트 탈수소효소 3 알파(IDH3A)를 과발현하는 형질전환 생쥐(transgenic mouse) 및 그 제조방법에 관한 것으로 상세하게는 CMV 프로모터, IDH3A 유전자 및 폴리아데닐화 서열을 포함하는 발현벡터로 형질전환된 생쥐 및 이러한 생쥐의 제조방법에 관한 것이다. 이러한 형질전환 생쥐는 IDH3A를 과발현하는 결과 비만 억제 형질을 나타내므로 비만 치료 및 연구를 위한 모델 동물로 이용할 수 있다.
IDH3A, TCA회로, 형질전환 생쥐, 비만
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