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公开(公告)号：KR1020150050631A
公开(公告)日：2015-05-11
申请号：KR1020130129261
申请日：2013-10-29
Applicant: 대한민국(농촌진흥청장) , 대구한의대학교산학협력단
Abstract: 본발명은코프리신펩타이드유도체 CopA3를함유하는항염증화장료및 피부외용제조성물에관한것으로, 더욱상세하게는염증으로유발되는피부질환의예방및 개선을위한코프리신펩타이드유도체 CopA3를함유하는항염증화장료및 피부외용제조성물에관한것이다. 본발명에따른항염증화장료조성물및 피부외용제조성물은서열번호 1로표시되는아미노산서열을가지는코프리신펩타이드유도체 CopA3를함유하는것을특징으로한다. 상기항염증화장료조성물및 피부외용제조성물은초기-염증성인자(pro-inflammatory mediator)의생성및 발현억제를유도함으로써염증으로유발되는피부질환의예방및 개선에효과적이다.
Abstract translation: 本发明涉及化妆品组合物和抗皮肤病学组合物。本发明涉及抗炎化妆品组合物和含有复合蛋白肽衍生物CopA3的皮肤病学组合物，更具体地，涉及抗炎化妆品组合物和皮肤病学 含有共感染肽衍生物CopA3的组合物，用于预防和减轻由炎症引起的皮肤疾病。 根据本发明，抗炎化妆品和皮肤病学组合物包含含有表示为序列号1的氨基酸序列的共立克斯肽衍生物CopA3。抗炎化妆品和皮肤病学组合物有效预防和减轻由炎症引起的皮肤疾病 通过诱导抑制促炎介质的产生和表达。
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公开(公告)号：KR1020150050627A
公开(公告)日：2015-05-11
申请号：KR1020130129234
申请日：2013-10-29
Applicant: 대한민국(농촌진흥청장) , 대구한의대학교산학협력단
CPC classification number: A61K8/64
Abstract: 본발명은무당벌레유충유래신규펩타이드를함유하는항염증화장료및 피부외용제조성물에관한것으로, 더욱상세하게는염증으로유발되는피부질환의예방및 개선을위한무당벌레유충유래신규펩타이드를함유하는항염증화장료및 피부외용제조성물에관한것이다. 본발명에따른항염증화장료조성물및 피부외용제조성물은서열번호 1로표시되는아미노산서열을가지는무당벌레유충유래신규펩타이드 HaGF를함유하는것을특징으로한다. 상기항염증화장료조성물및 피부외용제조성물은초기-염증성인자(pro-inflammatory mediator)의생성및 발현억제를유도함으로써염증으로유발되는피부질환의예방및 개선에효과적이다.
Abstract translation: 本发明涉及一种抗炎化妆品组合物和含有源自Harmonia axyridis幼虫的新肽的皮肤病学组合物，更具体地，涉及抗炎化妆品组合物和含有源自Harmonia axyridis幼虫的新肽的皮肤病学组合物，用于预防 并减轻炎症引起的皮肤病。 根据本发明，抗炎化妆品和皮肤病学组合物包含源自Harmonia axyridis幼虫的新肽HaGF，其含有表示为序列号1的氨基酸序列。抗炎化妆品和皮肤病学组合物有效预防和缓解皮肤 由炎症引起的疾病，通过诱导抑制生成和促炎介质的表达。
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公开(公告)号：KR101424125B1
公开(公告)日：2014-08-04
申请号：KR1020120126880
申请日：2012-11-09
Applicant: 대한민국(농촌진흥청장)
CPC classification number: Y02A50/40 , Y02A50/401
Abstract: 본 발명은 갈색거저리(
Tenebrio molitor ) 유충을 포함하는 염증성 질환 치료용 조성물에 관한 것으로, 갈색거저리 유충을 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학적 조성물, 염증성 질환 예방 또는 개선용 식품 조성물 및 사료용 조성물에 관한 것이다. 본 발명에 따른 갈색거저리 유충은 염증 관련 인자들인 NO, iNOS, TNF-α, IL-6, IL-1ß, NF-κB 의 발현을 억제하여 항염증활성을 보이고, 대식세포에 대한 독성이 없으므로, 염증성 질환의 예방 또는 치료용 약학적 조성물, 염증성 질환의 예방 또는 개선용 식품 조성물 또는 사료용 조성물의 제조에 이용할 수 있다.-
114.发明公开항염증 효능을 갖는 식약용 장수풍뎅이 또는 이의 유충의 전처리 방법 및 이를 통해 항염증 효능을 갖는 식약용 장수풍뎅이 또는 이의 유충추출물 有权具有抗炎作用的ALLOMYRINA DICHOTOMAA食品的预处理方法及其使用抗炎药效果的ALLOMYRINA DICHOTOMA提取物的食品
公开(公告)号：KR1020140090313A
公开(公告)日：2014-07-17
申请号：KR1020130000432
申请日：2013-01-03
Applicant: 대한민국(농촌진흥청장)
IPC: A01K67/033 , A01K67/00 , A23L35/00
CPC classification number: A01K67/033 , A01K2227/706 , A61K35/63
Abstract: The present invention relates to a method for pre-treating Allomyrina dichotoma to use the Allomyrina dichotoma as edible or medicinal materials and edible and medicinal Allomyrina dichotoma or a larva thereof which is pretreated by the method to have an anti-inflammatory effect. The method for pre-treating edible and medicinal Allomyrina dichotoma or a larva thereof having an anti-inflammatory effect, of the present invention, is characterized by comprising: a first step of feeding Allomyrina dichotoma or a larva thereof on a sterilized feed; a second step of starving the Allomyrina dichotoma or larva thereof fed on the sterilized feed; and a third step of sterilizing the starved Allomyrina dichotoma or larva thereof. According to the present invention, in order to use Allomyrina dichotoma or a larva thereof as edible or medicinal materials, the pre-treatment conditions of Allomyrina dichotoma was established to eliminate bacteria and remove a unique odor of Allomyrina dichotoma, and Allomyrina dichotoma was confirmed as a safe material without cytotoxicity. As a result of treating macrophagocytes with Allomyrina dichotoma, it was confirmed that Allomyrina dichotoma reduced the generation of inflammation related cytokine and inflammation mediators in the macro-phagocytes, and thus Allomyrina dichotoma can be useful in the preparation of edible and medicinal Allomyrina dichotoma and as anti-inflammatory medicinal materials or health food.
Abstract translation: 本发明涉及一种用于预处理Allomyrina dichotoma以使用Allomyrina dichotoma作为食用或药用物质的食品和药用Allomyrina dichotoma或其幼虫的方法，其通过该方法进行预处理以具有抗炎作用。 本发明的具有抗炎作用的食用和药用Allomyrina dichotoma或其幼虫的预处理方法的特征在于包括：向灭菌的饲料喂养Allomyrina dichotoma或其幼虫的第一步骤; 在灭菌饲料上喂食的Allomyrina dichotoma或幼虫的第二步骤; 以及对饥饿的Allomyrina dichotoma或其幼虫进行灭菌的第三步骤。 根据本发明，为了使用Allomyrina dichotoma或其幼虫作为食用或药用材料，建立了Allomyrina dichotoma的预处理条件以消除细菌并除去Allomyrina dichotoma的独特气味，Allomyrina dichotoma被证实为 没有细胞毒性的安全材料。 通过用Allomyrina dichotoma处理巨噬细胞的结果，证实了Allomyrina dichotoma减少了巨噬细胞中炎症相关细胞因子和炎症介质的产生，因此Allomyrina dichotoma可用于制备食用和药用Allomyrina dichotoma以及 抗炎药材或保健食品。
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公开(公告)号：KR1020140065489A
公开(公告)日：2014-05-30
申请号：KR1020120126884
申请日：2012-11-09
Applicant: 동아대학교 산학협력단 , 대한민국(농촌진흥청장)
Abstract: The present invention relates to a composition for preventing or treating dementia comprising an extract of the mealworm (Tenebrio molitor), particularly to a pharmaceutical composition for preventing or treating dementia and a food composition for preventing or alleviating demensia, comprising the extract of the mealworm as an active ingredient. According to the present invention, the extract of the mealworm inhibits activity of beta-secretase (BACE1) and thus is effectively used to manufacture a pharmaceutical composition for preventing or treating dementia or a food composition for preventing or alleviating dementia.
Abstract translation: 本发明涉及用于预防或治疗痴呆的组合物，其特征在于用于预防或治疗痴呆的药物组合物，以及用于预防或减轻病症的食物组合物，所述组合物包含所述蚯蚓（Tenebrio molitor）的提取物， 活性成分。 根据本发明，所述蚕丝虫提取物抑制β-分泌酶（BACE1）的活性，因此有效地用于制造用于预防或治疗痴呆的药物组合物或用于预防或减轻痴呆症的食物组合物。
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Patent Agency Ranking
公开(公告)号：KR1020140004036A
公开(公告)日：2014-01-10
申请号：KR1020130140516
申请日：2013-11-19
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K9/0053 , A61K9/20 , A61K9/48 , A61K31/726 , A61K35/63 , A61K47/38
Abstract: The present invention relates to a method for preparing an insect-derived composition for a preparation substituting for heparin and a use thereof. More specifically, the present invention relates to a method for preparing insect glycosaminoglycan capable of being used as a substituent for heparin or a composition for a preparation substituting for heparin, and a use of suppressing inflammation or enhancing immunity of the insect glycosaminoglycan or the composition for a preparation substituting for heparin, which is prepared by the said method. The preparation method of the present invention can provide useful glycosaminoglycan from insects. Furthermore and according to the preparation method of the present invention, heparin high and low molecular weight medicines, which are a kind of glycosaminoglycan, can be manufactured from various species of insects, and heparin and the likes can be produced at low costs whereby the present invention can contribute to the improvement of the national health and preserve the incomes of the insect breeding farmers.
Abstract translation: 本发明涉及一种制备代替肝素的制剂的昆虫衍生组合物及其用途的方法。 更具体地说，本发明涉及能够用作肝素取代基的昆虫糖胺聚糖的制备方法或用于替代肝素的制剂组合物，以及抑制炎症或增强昆虫糖胺聚糖或组合物的免疫力的用途 一种替代肝素的制剂，其通过所述方法制备。 本发明的制备方法可以从昆虫中提供有用的糖胺聚糖。 此外，根据本发明的制备方法，可以由各种昆虫制造作为一种糖胺聚糖的肝素高分子量药物，可以低成本制造肝素等， 发明可有助于改善国家卫生，保护昆虫繁殖农民的收入。
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公开(公告)号：KR1020130041863A
公开(公告)日：2013-04-25
申请号：KR1020130030546
申请日：2013-03-21
Applicant: 대한민국(농촌진흥청장)
IPC: C12P19/04 , C08B37/10 , A61K31/715 , A61P37/00
CPC classification number: C12P19/04 , A61K31/715 , C08B37/0075 , C12Y402/02007
Abstract: PURPOSE: A method for preparing an insect-derived heparin substituent composition and a use thereof are provided to manufacture high molecular and low molecular drugs from various kinds of insects. CONSTITUTION: A method for preparing an insect-derived heparin substituent composition comprises: a step of immersing insects in an organic solvent, removing fats, filtering, and drying a residue; a step of pulverizing the dried residue; a step of treating the residue with protease and hydrolyzing proteins; a step of removing hydrolyzed proteins; a step of collecting saccharides and obtaining insect glycosaminoglycan; and a step of hydrolyzing the insect glycosaminoglycan and removing sulfate groups.
Abstract translation: 目的：提供一种制备昆虫来源的肝素取代基组合物的方法及其用途，用于制备各种昆虫的高分子和低分子药物。 构成：制备昆虫来源的肝素取代基组合物的方法包括：将昆虫浸入有机溶剂中，除去脂肪，过滤和干燥残留物的步骤; 粉碎干燥残渣的步骤; 用蛋白酶处理残留物并水解蛋白质的步骤; 去除水解蛋白的步骤; 收集糖类并获得昆虫糖胺聚糖的步骤; 和水解昆虫糖胺聚糖并除去硫酸根的步骤。
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公开(公告)号：KR101200406B1
公开(公告)日：2012-11-14
申请号：KR1020110085623
申请日：2011-08-26
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/726 , A61K35/64 , A61K38/48 , A61K9/19
Abstract: 본 발명은 곤충글라이코자미노글라이칸의 소염, 항당뇨, 항응혈, 항암, 혈관신생억제 용도, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방 용도와 곤충글라이코자미노글라이칸 제조방법을 제공한다. 본 발명의 곤충글라이코자미노글라이칸에 의해 소염, 항당뇨, 항응혈, 항암, 혈관신생억제, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방할 수 있으며, 본 발명의 제조방법에 의해 곤충글라이코자미노글라이칸을 효과적으로 제조할 수 있다.
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119.发明授权
公开(公告)号：KR101200404B1
公开(公告)日：2012-11-14
申请号：KR1020110085667
申请日：2011-08-26
Applicant: 대한민국(농촌진흥청장)
IPC: A61K31/726 , A61K35/64 , A61K38/48 , A61K9/19
Abstract: 본 발명은 곤충글라이코자미노글라이칸의 소염, 항당뇨, 항응혈, 항암, 혈관신생억제 용도, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방 용도와 곤충글라이코자미노글라이칸 제조방법을 제공한다. 본 발명의 곤충글라이코자미노글라이칸에 의해 소염, 항당뇨, 항응혈, 항암, 혈관신생억제, 및/또는 혈관확장반응의 기능장애로 인한 질환 치료 및/또는 예방할 수 있으며, 본 발명의 제조방법에 의해 곤충글라이코자미노글라이칸을 효과적으로 제조할 수 있다.
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120.发明公开초파리 히포신호 관련 ｓｃａｌｌｏｐｅｄ 유전자로부터 발현되는 단백질을 포함하는 장 줄기세포 분화 촉진용 조성물 및 염증성 장질환 치료용 조성물 有权用于促进肠干细胞增殖和用于治疗炎性肠病的组合物，其包含从果蝇中基因相关的河马信号通路表达的蛋白质
公开(公告)号：KR1020120123231A
公开(公告)日：2012-11-08
申请号：KR1020120107295
申请日：2012-09-26
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61K38/1767 , C07K14/43581 , C12N15/63 , Y10S514/886
Abstract: PURPOSE: A composition for preventing and treating inflammatory bowel diseases is provided to obtain a novel candidate material for treating inflammatory bowel diseases. CONSTITUTION: A composition for preventing and treating inflammatory bowel diseases contains polypeptide of sequence number 3 as an active ingredient. The polypeptide is encoded by a polynucleotide of sequence number 4. The composition contains a promoter and a vector containing a polynucleotide of sequence number 4, which is operatively linked to the same. The pharmaceutical composition is manufactured in the form for administration or parenteral administration.
Abstract translation: 目的：提供一种预防和治疗炎性肠病的组合物，以获得治疗炎症性肠病的新型候选材料。 构成：用于预防和治疗炎性肠病的组合物含有序列号3的多肽作为活性成分。 该多肽由序列号4的多核苷酸编码。该组合物含有启动子和含有序列号4的多核苷酸的载体，其与其可操作地连接。 药物组合物以用于给药或肠胃外给药的形式制备。
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