公开(公告)号：TN2019000107A1

公开(公告)日：2020-10-05

申请号：TN2019000107

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  JIANG YUTONG ,  ARONOW SEAN ,  COOK ADAM ,  MORENO DAVID A ,  RAMANN GINELLE A ,  ANDREWS STEVEN W ,  TANG TONY P ,  BRANDHUBER BARBARA J ,  COLLIER JAMES ,  MCNULTY OREN T ,  REN LI ,  BLAKE JAMES F ,  METCALF ANDREW T ,  WALLS SHANE M ,  HAAS JULIA

IPC: A61P35/00 ,  A61K31/437 ,  C07D471/04

Abstract: Provided herein are compounds of the Formula (I), or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X 1 , X 2 , X 3 , X 4 , Ring D, E, R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

公开(公告)号：RS60536B1

公开(公告)日：2020-08-31

申请号：RSP20200861

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  TANG TONY P ,  REN LI

IPC: A61K31/437 ,  C07D471/04 ,  A61P35/00

公开(公告)号：LT3523301T

公开(公告)日：2020-07-27

申请号：LT17787843

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  TANG TONY P ,  REN LI

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：EA035568B1

公开(公告)日：2020-07-08

申请号：EA201990940

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  TANG TONY P ,  REN LI

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Визобретениипредложенысоединенияформулы Iиихстереоизомерыи фармацевтическиприемлемыесолиилисольваты, вкоторых A, B, X, X, X, X, кольцо D и E имеютзначения, приведенныев описании, которыеявляютсяингибиторами RET киназыи полезныприлечениии профилактикезаболеваний, которыемогутлечитьсяингибитором RET киназы, включаязаболеванияи расстройства, связанныес RET.

公开(公告)号：AU2018369759A1

公开(公告)日：2020-06-25

申请号：AU2018369759

申请日：2018-11-14

Applicant: ARRAY BIOPHARMA INC ,  MIRATI THERAPEUTICS INC

Inventor： BLAKE JAMES F ,  BURGESS LAURENCE E ,  CHICARELLI MARK JOSEPH ,  CHRISTENSEN JAMES GAIL ,  COOK ADAM ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  MARX MATTHEW ARNOLD ,  MEJIA MACEDONIO J ,  SAVECHENKOV PAVEL ,  VIGERS GUY P A ,  SMITH CHRISTOPHER RONALD ,  RODRIGUEZ MARTHA E

IPC: C07D401/06 ,  C07D401/14

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

公开(公告)号：CA3116561A1

公开(公告)日：2020-04-23

申请号：CA3116561

申请日：2019-10-17

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  FELL JAY B ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: C07D401/04 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds of Formula la or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases in the view of their ability to inhibit SHP2. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：ECSP19032676A

公开(公告)日：2019-07-31

申请号：ECDI201932676

申请日：2019-05-09

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  MORENO DAVID A ,  HAAS JULIA ,  MCKENNEY MEGAN L ,  COOK ADAM ,  JIANG YUTONG ,  ANDREWS STEVEN W ,  TANG TONY P ,  ARONOW SEAN ,  METCALF ANDREW T ,  MCFADDIN ELIZABETH A ,  REN LI ,  MCNULTY OREN T ,  KOLAKOWSKI GABRIELLE R

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Se proporciona en la presente compuestos de la Fórmula I y estereoisómeros y sales o solvatos aceptables desde el punto de vista farmacéutico de estos, en donde A, B, X1, X2, X3, X4, Anillo D y E tienen los significados dados en la memoria descriptiva, que son inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratara con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos.

公开(公告)号：CA3082579A1

公开(公告)日：2019-05-23

申请号：CA3082579

申请日：2018-11-14

Applicant: MIRATI THERAPEUTICS INC ,  ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BURGESS LAURENCE E ,  CHICARELLI MARK JOSEPH ,  CHRISTENSEN JAMES GAIL ,  COOK ADAM ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  MARX MATTHEW ARNOLD ,  MEJIA MACEDONIO J ,  SAVECHENKOV PAVEL ,  VIGERS GUY P A ,  SMITH CHRISTOPHER RONALD ,  RODRIGUEZ MARTHA E

IPC: C07D401/06 ,  C07D401/14

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

公开(公告)号：AU2017342027A1

公开(公告)日：2019-05-23

申请号：AU2017342027

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  COLLIER JAMES ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  RAMANN GINELLE A ,  TANG TONY P ,  REN LI ,  WALLS SHANE M

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X

公开(公告)号：AU2017342022A1

公开(公告)日：2019-05-23

申请号：AU2017342022

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDHUBER BARBARA J ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  TANG TONY P ,  REN LI

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula I and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X