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    DEVICE FOR SAMPLING TISSUES AND FLUIDS FROM BODILY CAVITIES
    111.
    发明申请
    DEVICE FOR SAMPLING TISSUES AND FLUIDS FROM BODILY CAVITIES 审中-公开
    从身体采集组织和液体的设备

    公开(公告)号：WO1986007532A1

    公开(公告)日：1986-12-31

    申请号：PCT/US1986001113

    申请日：1986-05-23

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  BROOKER, Doris, C.

    IPC: A61B10/00

    CPC classification number: A61B10/0291 ,  A61B10/0045 ,  A61B10/0283 ,  A61B10/04 ,  A61B2090/034

    Abstract: A device (10) and process for sampling tissue and fluid from bodily cavities comprises an aspirating curette (11) with a notch (27) at its distal end (23). The curette (11) is slidably mounted in and encased by a protective sleeve (17) that has a plug (20) at its outer end. The sleeve (17) is shorter than the curette (11) and a removable stop member (19) is provided to initially limit the movement of the sleeve (17) toward the base of the curette. When the sleeve (17) and curette (11) have been inserted into the bodily cavity the stop (19) is removed, permitting the curette (11) to be moved outwardly through the sleeve (17), dislodging the plug (20) and exposing the notch (27). Fluids may be drawn into the curette which is then rotated to scrape the cavity wall, and drawn back into the sleeve (17). The apparatus is then removed from the bodily cavity as a unit with the curette (11) and collected specimen protected from contamination and from oxygen.

    Abstract translation: 用于从身体腔抽取组织和流体的装置（10）和方法包括在其远端（23）处具有凹口（27）的抽吸刮匙（11）。 刮刀（11）可滑动地安装在保护套（17）中，保护套（17）在其外端具有插头（20）。 套筒（17）比刮匙（11）短，并且提供可移除的止动构件（19）以最初限制套筒（17）朝向刮板的基部的移动。 当套筒（17）和刮匙（11）已经插入到体腔中时，移除止动件（19），允许刮刀（11）通过套筒（17）向外移动，移除塞子（20）和 露出凹口（27）。 流体可以被吸入刮板中，然后旋转刮刀以刮擦空腔壁，并将其拉回到套筒（17）中。 然后将该装置作为具有刮匙（11）的单元从身体腔中取出，并收集样品，防止污染和氧气。

    METHOD FOR THE EARLY DIAGNOSIS OF BORDETELLA DISEASES AND KIT THEREFOR
    112.
    发明申请
    METHOD FOR THE EARLY DIAGNOSIS OF BORDETELLA DISEASES AND KIT THEREFOR 审中-公开
    早期诊断BORDETELLA病及其套件的方法

    公开(公告)号：WO1986005205A1

    公开(公告)日：1986-09-12

    申请号：PCT/US1986000447

    申请日：1986-02-26

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  CONFER, Dennis, L. ,  EATON, John, W.

    IPC: C12Q01/00

    CPC classification number: G01N33/566 ,  C12Q1/04 ,  C12Q1/527 ,  G01N2333/235 ,  Y10S435/803 ,  Y10S436/81

    Abstract: A method for the early diagnosis of Bordetella diseases based on the detection of Bordetella adenylate cyclase and the ability of this enzyme to catalyze the formation of cyclic adenosine monophosphate (cAMP). A sample secretion is taken from a suspected victim of a Bordetella disease (the most common of which in humans is whooping cough) and incubated under conditions to promote the formation of cAMP, which may then be measured as evidence of the presence of the disease. A sample of nasopharyngeal secretions is maintained in a nutrient medium pending assay. An adenylate cyclase assay is made by incubating the sample with adenosine triphosphate (ATP) and the calcium binding protein calmodulin to generate cAMP. The cAMP is measured by any of several known available methods. To facilitate diagnosis, a kit is provided containing the materials necessary for collection of secretion specimens, for storage of specimens pending assay, and transport of specimens to the assay laboratory, and for performing the assay and determining the result.

    FOLDED LOGIC GATE
    113.
    发明申请
    FOLDED LOGIC GATE 审中-公开
    折叠逻辑门

    公开(公告)号：WO1986002778A1

    公开(公告)日：1986-05-09

    申请号：PCT/US1985001906

    申请日：1985-10-04

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  SHUR, Michael, S.

    IPC: H01L27/02

    CPC classification number: H01L27/0688

    Abstract: An FET logic gate structure (10) includes two semiconductor layers (18, 32) separated by an insulator (16). An enhancement mode switching FET (12) is formed in the top semiconductor layer (18), and a load element (14) is formed in the bottom semiconductor layer (32). The insulator layer (16) separates and capacitively couples the switching element (12) and the load element (14) so that the switching element (12) acts as a gate for the load element (14) and the load element (14) acts as a second gate of the switching element (12). An input (44) is connected to the gate (26) of the switching element (12). The drain (30) of the switching element (12), the source (40) of the load element (14), and the output (46) of the folded logic gate (10) are connected together. The logic gate structure (10) exhibits very low power consumption in stable states, high speed and large output voltage swings.

    MUTANTS OF STREPTOCOCCAL TOXIN A AND METHODS OF USE
    114.
    发明申请
    MUTANTS OF STREPTOCOCCAL TOXIN A AND METHODS OF USE 审中-公开
    管状毒素A的突变体及其使用方法

    公开(公告)号：WO1998024911A2

    公开(公告)日：1998-06-11

    申请号：PCT/US1997022228

    申请日：1997-12-05

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  SCHLIEVERT, Patrick, M. ,  ROGGIANI, Manuela ,  STOEHR, Jennifer ,  OHLENDORF, Douglas

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

    IPC: C12N15/31

    CPC classification number: C07K14/315 ,  A61K38/00 ,  A61K39/00

    Abstract: This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.

    Abstract translation: 本发明涉及突变体SPE-A毒素或其片段，疫苗和药物组合物，以及使用疫苗和药物组合物的方法。 与野生型SPE-A毒素相比，优选的SPE-A毒素具有至少一个氨基酸变化并且基本上是非致死的。 突变型SPE-A毒素可以形成用于保护动物免受野生型SPE-A毒素生物活性的疫苗组合物。

    METHOD FOR IMMORTALIZING CELLS
    116.
    发明申请
    METHOD FOR IMMORTALIZING CELLS 审中-公开
    用于使细胞移植的方法

    公开(公告)号：WO1998006827A2

    公开(公告)日：1998-02-19

    申请号：PCT/US1997014391

    申请日：1997-08-13

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  FOSTER, Douglas, N. ,  FARRIS, James, A. ,  FOSTER, Linda, K.

    IPC: C12N05/10

    CPC classification number: C07K14/4746 ,  C12N7/00 ,  C12N2710/16351 ,  C12N2720/12051

    Abstract: This invention relates to the introduction of p53 under the control of the metallothionein promoter into primary cells to produce immortalized cell lines. The cells are useful as substrates for viral propagation, as contaminant-free sources for recombinant protein production, for recombinant virus production and as cell substrates to support primary cells and improve virus yield during virus propagation.

    Abstract translation: 本发明涉及在金属硫蛋白启动子控制下将p53引入原代细胞以产生永生化细胞系。 细胞可用作病毒繁殖的底物，作为用于重组蛋白质生产的无污染源，用于重组病毒生产，以及作为支持原代细胞的细胞底物并改善病毒繁殖期间的病毒产量。

    METHOD FOR SELECTIVE ENGRAFTMENT OF DRUG-RESISTANT HEMATOPOIETIC STEM CELLS
    119.
    发明申请
    METHOD FOR SELECTIVE ENGRAFTMENT OF DRUG-RESISTANT HEMATOPOIETIC STEM CELLS 审中-公开
    选择性克隆耐药性HEMATOPOIETIC干细胞的方法

    公开(公告)号：WO1997032025A1

    公开(公告)日：1997-09-04

    申请号：PCT/US1997002772

    申请日：1997-02-26

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  MCIVOR, R., Scott ,  JAMES, Rohaizah, Ismail ,  MAY, Chad

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

    IPC: C12N15/53

    CPC classification number: C12N9/003 ,  A01K67/0271 ,  A61K48/00 ,  A61K2035/124 ,  C12N2510/00

    Abstract: A method for the selective engraftment of hematopoietic stem cells is provided for increasing the efficiency of hematopoietic stem cell engraftment in vivo, comprising: (a) administering to a mammal a population of stem cells, comprising transgenic stem cells, the genome of which has been augmented by a first preselected DNA segment, which encodes resistance to an agent, and which said first preselected DNA segment is operably linked to a promoter functional in stem cells, wherein the expression of the first preselected DNA segment in the transgenic stem cells is sufficient to impart resistance or tolerance to said transgenic cells to an amount of the agent which is toxic to nontransgenic stem cells, the genome of which has not been augmented by the first preselected DNA segment; and (b) administering said agent to said mammal in an amount and for a time so as to increase the engraftment of transgenic stem cells relative to the engraftment of nontransgenic stem cells.

    Abstract translation: 提供了用于增加造血干细胞选择性移植的方法，用于提高体内造血干细胞移植的效率，包括：（a）向哺乳动物施用包含转基因干细胞的干细胞群，其基因组已被 通过编码对药物的抗性的第一预选DNA片段增强，并且所述第一预选DNA片段可操作地连接到干细胞中功能性的启动子，其中转基因干细胞中第一预选DNA片段的表达足以 将所述转基因细胞的抗性或耐受性赋予对非转基因干细胞有毒的剂量，其基因组未被第一预选DNA片段增强; 和（b）在一定量和一段时间内向所述哺乳动物施用所述药物，以增加转基因干细胞相对于非转基因干细胞移植的移植。

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