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公开(公告)号：EP1718452A1
公开(公告)日：2006-11-08
申请号：EP05713885.1
申请日：2005-02-22
Applicant: 3M Innovative Properties Company
Inventor： BOONE, Mary, R. , CARTER, Chad, J. , FREDERICKSON, Franklyn, L.
CPC classification number: B29C45/372 , A61B17/205 , A61B2017/00526 , A61B2017/00893 , A61M37/0015 , A61M2037/0053 , B29C33/3842 , B29C33/3857 , B29C33/42 , B29C45/2669 , B29C45/37 , B29C45/561 , B29C45/73 , B29C2045/0094 , B29C2045/7393 , B29L2031/753 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C99/0085 , C25D1/10
Abstract: A method of manufacturing a moldable microneedle array (54) is described comprising providing a negative mold insert (44) characterized by a negative image of microneedle topography wherein at least one negative image of a microneedle is characterized by an aspect ratio of between about 2 to 1 and about 5 to 1. The negative mold insert (44) is used to define a structured surface of a negative mold cavity (42). Molten plastic material is injected into the heated negative mold cavity. The molten plastic material is subsequently cooled and detached from the mold insert to provide a molded microneedle array (54). One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin.
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112.发明公开
公开(公告)号：EP1364396A4
公开(公告)日：2005-08-31
申请号：EP02718901
申请日：2002-02-05
Applicant: BECTON DICKINSON CO
Inventor： EVANS JOHN D , KELLER CHRIS
IPC: A61B5/15 , A61M5/32 , A61M35/00 , A61M37/00 , B61C1/00 , B81B1/00 , B81C1/00 , B44C1/22 , H01L21/302
CPC classification number: A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61M2037/003 , A61M2037/0053 , B81B2201/055 , B81C1/00111 , B81C2201/0133
Abstract: A microprotrusion array is formed from a silicon wafer by a plurality of sequential plasma and wet isotropic and anisotropic etching steps. The resulting microprotrusions have sharpened tips or cutting edges formed by a wet isotropic etch.
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公开(公告)号：EP1183064A1
公开(公告)日：2002-03-06
申请号：EP00942691.7
申请日：2000-06-07
Applicant: THE PROCTER & GAMBLE COMPANY
Inventor： SHERMAN, Faiz, F. , YUZHAKOV, Vadim Vladimirovich , GARTSTEIN, Vladimir , OWENS, Grover, David
CPC classification number: B29C51/082 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B26F1/24 , B29C33/0033 , B29C33/42 , B29C37/0053 , B29C45/2628 , B29C51/00 , B29C2059/023 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111 , B81C2201/036
Abstract: A microneedle array is manufactured using a mold preparation procedure that begins by placing an optical mask over a layer of PMMA material, exposing the PMMA material to x-rays, then developing using a photoresist process. The remaining PMMA material is then electroplated with metal. Once the metal has reached an appropriate thickness, it is detached to become a metal mold that is used in a microembossing procedure, in which the metal mold is pressed against a heated layer of plastic material. Once the mold is pressed down to its proper distance, the plastic material is cooled until solidified, and the mold is then detached, thereby leaving behind an array of microneedles. If the microneedles are hollow, then an additional procedure is used to create through-holes all the way through the underlying substrate material using laser optical means.
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公开(公告)号：EP1086214A1
公开(公告)日：2001-03-28
申请号：EP99928580.2
申请日：1999-06-10
Applicant: GEORGIA TECH RESEARCH CORPORATION
Inventor： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , MCALLISTER, Devin, V. , HENRY, Sebastien , CROS, Florent, Paul, Marcel
IPC: C12N15/00
CPC classification number: B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B81B2201/055
Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers. In a preferred embodiment, the microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
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公开(公告)号：KR101261466B1
公开(公告)日：2013-05-10
申请号：KR1020090065324
申请日：2009-07-17
Applicant: 한국전자통신연구원
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3842 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111
Abstract: 본발명에따른마이크로니들의제조방법은관통홀을가지는사출금형을형성하는단계, 점성물질의감광액을상기사출금형에충진하고, 상기관통홀을통해압출하는단계, 상기압출된감광액을고형화하여바늘형상의감광액구조를형성하는단계, 상기감광액구조의표면에시드막을형성하는단계, 상기시드막위에금속도금막을형성하는단계, 상기금속도금막이형성된상기감광액구조의끝단에경사를형성하는단계, 그리고상기금속도금막내부의상기감광액을제거하여할로우를형성하는단계를포함한다. 따라서, 최소통증제어가가능하도록직경, 길이, 경도, 경사각을갖는할로우미세제작바늘을제작할수 있으며, 혈액등의체내생체물질의검출, 미용및 약물주입을위한장치와결합하여다양하게응용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120006293A
公开(公告)日：2012-01-18
申请号：KR1020100066940
申请日：2010-07-12
Applicant: 인싸이토(주)
CPC classification number: A61M5/00 , A61B5/14532 , A61B5/14865 , A61B5/685 , A61F9/00781 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C41/08 , B29C41/36 , B29C41/38 , B29D23/00 , B29L2031/7544 , B81B2201/055 , B81C1/00111 , G01N33/49
Abstract: PURPOSE: A hollow micro needle whose external shape is changeable is provided to control an effective length, the inner diameter and outer diameter of an upper part, the diameter and the hardness of a lower part, a sharpness degree, an inclined angle, an aspect ratio, and a bending degree. CONSTITUTION: A method for manufacturing a hollow micro needle whose external shape is changeable comprises the following steps. A viscid solution is spread on a board. The viscid solution contacts a frame. The board, the frame, or the board and the frame are lifted to separate the frame from the board which contacts the frame so that a solid micro structure is manufactured. Metal is deposited on the solid micro structure. Metal is plated on the surface of the micro structure while protecting the upper part of the solid micro structure on which metal is deposited. A hollow micro structure is obtained by eliminating the solid micro structure.
Abstract translation: 目的：提供外形可变的中空微针，用于控制上部的有效长度，内径和外径，下部的直径和硬度，锐度，倾斜角度，方面 比例和弯曲度。 构成：用于制造外部形状可变的中空微针的方法包括以下步骤。 粘性溶液散布在电路板上。 粘稠溶液接触框架。 板，框架或板和框架被提起以将框架与与框架接触的板分离，从而制造实心微结构。 金属沉积在固体微结构上。 金属镀在微结构的表面上，同时保护沉积金属的固体微结构的上部。 通过消除固体微结构获得中空微结构。
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公开(公告)号：KR1020110007734A
公开(公告)日：2011-01-25
申请号：KR1020090065324
申请日：2009-07-17
Applicant: 한국전자통신연구원
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3842 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111
Abstract: PURPOSE: A method for manufacturing a hallow micro needle is provided to realize minimum pain control. CONSTITUTION: A method for manufacturing a hallow micro needle comprises the following steps. An injection mold with a penetration groove is formed. The injection mold is filled with photosensitive liquid of a viscosity material. The photosensitive liquid is compressed through a penetration hole. The compressed photosensitive liquid is hardened to form a photosensitive liquid structure of a needle shape. A seed film is formed on the surface of the photosensitive liquid structure. A metal plating film is formed on the seed film. The end of the photosensitive liquid structure with the metal plating film is inclined. The photosensitive liquid structure inside the metal plating film is removed to form a hollow.
Abstract translation: 目的：提供一种制造神经微针的方法，以实现最小的疼痛控制。 构成：制造中空微针的方法包括以下步骤。 形成具有贯通槽的注射模具。 注射模具充满粘度物质的感光性液体。 感光性液体通过贯通孔进行压缩。 将压缩的感光性液体硬化，形成针状感光性液体结构。 在感光性液晶结构体的表面形成种子膜。 在种皮膜上形成金属镀膜。 具有金属镀膜的光敏液体结构的端部是倾斜的。 去除金属镀膜内部的感光性液体结构，形成中空部。
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公开(公告)号：KR1020060089314A
公开(公告)日：2006-08-09
申请号：KR1020050009916
申请日：2005-02-03
Applicant: 삼성전자주식회사
Inventor： 이창승
IPC: B81C99/00
CPC classification number: B81C1/00111 , A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81C2201/0115
Abstract: 마이크로 니들 어레이 제조방법이 개시된다. 개시된 본 발명에 따른 마이크로 니들 어레이 제조방법은, 제 1 표면 및 제 1 표면과 소정 간격 이격된 제 2 표면을 갖는 기판을 준비한 후, 제 1 표면을 패터닝 하여 마이크로 니들 몸체의 형상을 형성시킨다. 그리고, 다공성 실리콘 공정에 의해 제 2 표면에서부터 제 1 표면을 관통하는 미세통로를 형성시킨 후, 다수의 미세통로를 통합하여 마이크로 니들의 몸체와 채널을 형성시킨다.
마이크로 니들, 채널, 몸체, 가로 세로 비, 실리콘, 실리콘 옥사이드, 다공성 실리콘-
公开(公告)号：KR100563330B1
公开(公告)日：2006-03-22
申请号：KR1020030003041
申请日：2003-01-16
Applicant: 포스트마이크로 주식회사
IPC: B29D99/00
CPC classification number: B81C99/0085 , A61B5/14514 , A61M37/0015 , A61M2037/0053 , B81B2201/055 , B81C2201/032 , G03F7/00 , G03F7/0035
Abstract: 본 발명은 X-선 공정을 이용한 미세 바늘 어레이의 제조방법을 제공하기 위한 것으로, 본 발명은 실리콘 기판 위에 미세 바늘 어레이 구조의 흡수체를 형성하여 X-선 마스크를 제작하는 단계; 상기 X-선 마스크를 이용하여 PMMA 위에 X-선 수직 노광 및 경사노광하여 미세 바늘 어레이 PMMA 형틀을 제작하는 단계; 상기 PMMA 형틀 위에 PDMS를 부어 반대형상을 갖는 유연한 PDMS 금형을 제작하는 단계; 상기 PDMS 금형 위에 겔 형태의 폴리머를 채우고 소망하는 두께를 형성하는 단계; 상기 폴리머에 UV를 조사하여 소망하는 형태의 구멍을 형상식각하는 단계; 상기 PDMS 금형을 떼어내어 폴리머 재질의 미세 바늘 어레이를 완성하는 단계;를 포함하는 것을 특징으로 한다.
이와 같은 본 발명에 따른 미세 바늘 어레이는 폴리머 재질을 이용하여 피부로부터 혈액을 추출하거나 약품을 주입할 수 있는 장치이다.-
公开(公告)号：US20230174372A1
公开(公告)日：2023-06-08
申请号：US17540750
申请日：2021-12-02
Applicant: Sangwoo Lee
Inventor： Sangwoo Lee
CPC classification number: B81C1/00111 , A61B5/293 , B81B1/008 , A61B2562/125 , A61N1/0529 , B81B2201/055 , B81B2203/04 , B81B2203/0361 , B81C2201/0133
Abstract: A method of manufacturing a plurality of neural probes from a silicon wafer in which after neural probes are formed on one side of a silicon wafer, the other side of the silicon wafter is subject to a dicing process that separates and adjusts the thickness of the neural probes.
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