公开(公告)号：JP6064231B2

公开(公告)日：2017-01-25

申请号：JP2014513311

申请日：2012-05-31

Applicant: オンコセラピー・サイエンス株式会社

Inventor： 浜本 隆二 ,  中村 祐輔 ,  角田 卓也

IPC: C12Q1/48 ,  G01N33/15 ,  C12Q1/06

CPC classification number: C12Q1/6886 ,  C12N15/1137 ,  C12Q1/48 ,  C12Y201/01043 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57423 ,  G01N33/57434 ,  C12N2310/14 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

公开(公告)号：JP4879912B2

公开(公告)日：2012-02-22

申请号：JP2007557265

申请日：2006-06-23

Applicant: オンコセラピー・サイエンス株式会社

Inventor： 祐輔 中村 ,  修一 中鶴 ,  洋一 古川 ,  隆二 浜本

IPC: C12Q1/48 ,  A61K45/00 ,  A61P35/00 ,  C07K14/47 ,  C12N9/10 ,  C12N15/09 ,  C12Q1/34 ,  G01N33/15 ,  G01N33/50

CPC classification number: G01N33/5011 ,  C12Q1/48 ,  C12Y201/01043 ,  G01N33/57407 ,  G01N2333/4736 ,  G01N2333/91011 ,  G01N2500/02

公开(公告)号：JP4467559B2

公开(公告)日：2010-05-26

申请号：JP2006502685

申请日：2004-02-27

Applicant: オンコセラピー・サイエンス株式会社

Inventor： 祐輔 中村 ,  洋一 古川

IPC: C12N15/113 ,  A61K31/713 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C12N20060101 ,  C12N15/12

CPC classification number: C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y201/01043

公开(公告)号：EP4352213A1

公开(公告)日：2024-04-17

申请号：EP22805231.2

申请日：2022-05-16

Applicant: Merck Sharp & Dohme LLC

Inventor： CRISTESCU, Razvan ,  DETTMAN, Elisha ,  LI, Yongjin ,  RODRIGUEZ-LOPEZ, Karla Gabriela ,  NEBOZHYN, Michael ,  PERINI, Rodolfo Fleury ,  PREDOIU, Raluca Andreia ,  ZHANG, Yiwei

IPC: C12N9/10 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  A61P35/00

CPC classification number: A61P35/00 ,  C12Q1/6886 ,  C12N9/1007 ,  C12Y201/01043 ,  C12Q2600/15820130101 ,  C07K16/2818

公开(公告)号：EP3260540A1

公开(公告)日：2017-12-27

申请号：EP17000579.7

申请日：2011-11-12

Applicant: The General Hospital Corporation

Inventor： Lee, Jeannie T ,  Zhao, Jing ,  Sarma, Kavitha ,  Borowsky, Mark ,  Ohsumi, Toshiro Kendrick

IPC: C12N15/113 ,  A61K9/127 ,  A61K31/713 ,  C12Q1/68

CPC classification number: C12N15/1137 ,  A61K9/1271 ,  A61K31/713 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2330/31 ,  C12Q1/6876 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y201/01043

Abstract: This invention relates to long non-coding RNAs (IncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2, inhibitory nucleic acids and methods and compositions for targeting IncRNAs.






d

Abstract translation: 本发明涉及长非编码RNA（IncRNA），结合染色质修饰剂的那些ncRNA的文库，例如Polycomb抑制性复合物2，抑制性核酸以及用于靶向IncRNA的方法和组合物。 d

公开(公告)号：EP3209783A1

公开(公告)日：2017-08-30

申请号：EP15794644.3

申请日：2015-10-23

Applicant: Ospedale San Raffaele S.r.l. ,  Fondazione Telethon

Inventor： NALDINI, Luigi ,  LOMBARDO, Angelo Leone ,  AMABILE, Angelo ,  MIGLIARA, Alessandro

IPC: C12N15/85 ,  A61K48/00 ,  A61K38/45 ,  C12N9/10

CPC classification number: C12N9/1007 ,  A61K35/12 ,  A61K38/1709 ,  A61K38/45 ,  A61K48/005 ,  C07K14/4703 ,  C07K2319/80 ,  C12N2740/16043 ,  C12Y201/01037 ,  C12Y201/01043

Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).

Abstract translation: 包含选自组（a），（b），（c）或（d）的两种或更多种人工转录阻遏物（ATR）或其编码多核苷酸的产物：（a）包含可操作连接的DNA结合结构域的ATR 到KRAB结构域或其同源物; （b）包含可操作地连接于DNMT3A，DNMT3B或DNMT1结构域或其同源物的DNA结合结构域的ATR; （c）包含可操作地连接至DNMT3L结构域或其同源物的DNA结合结构域的ATR; （d）包含可操作地连接至SETDB1结构域或其同源物的DNA结合结构域的ATR，其中至少两个ATR选自不同的组（a），（b），（c）或（d）。

公开(公告)号：EP2714903A4

公开(公告)日：2014-12-31

申请号：EP12792440

申请日：2012-05-31

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： HAMAMOTO RYUJI ,  NAKAMURA YUSUKE ,  TSUNODA TAKUYA

IPC: C12Q1/68 ,  A61K31/713 ,  A61K48/00 ,  A61P35/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/48 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y201/01043 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57423 ,  G01N33/57434 ,  G01N2500/04

Abstract: Objective methods for detecting or diagnosing cancer, or determining a predisposition for developing cancer, particularly lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor, are described herein. In one embodiment, the diagnostic method involves determining an expression level of the SUV39H2 gene. The present invention further provides methods of screening for candidate substances useful in the treatment and/or prevention of an SUV39H2-associated cancer, such as lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor. The present invention further provides methods of inhibiting the cell growth and thereby treating or alleviating symptoms of an SUV39H2 associated cancer. The present invention also features double-stranded molecules against the SUV39H2 gene and vectors encoding thereof as well as compositions containing such components and their utility in connection with the treatment and prevention of an SUV39H2-associated cancer.

公开(公告)号：EP2714903A1

公开(公告)日：2014-04-09

申请号：EP12792440.5

申请日：2012-05-31

Applicant: OncoTherapy Science, Inc.

Inventor： HAMAMOTO, Ryuji ,  NAKAMURA, Yusuke ,  TSUNODA, Takuya

IPC: C12N15/09 ,  A61K31/713 ,  A61K48/00 ,  A61P35/00 ,  C12N15/113 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/48 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y201/01043 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57423 ,  G01N33/57434 ,  G01N2500/04

Abstract: Objective methods for detecting or diagnosing cancer, or determining a predisposition for developing cancer, particularly lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor, are described herein. In one embodiment, the diagnostic method involves determining an expression level of the SUV39H2 gene. The present invention further provides methods of screening for candidate substances useful in the treatment and/or prevention of an SUV39H2-associated cancer, such as lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor. The present invention further provides methods of inhibiting the cell growth and thereby treating or alleviating symptoms of an SUV39H2 associated cancer. The present invention also features double-stranded molecules against the SUV39H2 gene and vectors encoding thereof as well as compositions containing such components and their utility in connection with the treatment and prevention of an SUV39H2-associated cancer.

公开(公告)号：EP1913152B1

公开(公告)日：2014-03-26

申请号：EP06780670.3

申请日：2006-06-23

Applicant: Oncotherapy Science, Inc.

Inventor： NAKAMURA, Yusuke c/o The University Of Tokyo ,  FURUKAWA, Yoichi c/o The University Of Tokyo ,  HAMAMOTO, Ryuji c/o The University Of Tokyo ,  NAKATSURU, Shuichi c/o Oncotherapy Science, Inc.

IPC: C12Q1/48 ,  G01N33/68 ,  A61P35/00 ,  A61K38/00

CPC classification number: G01N33/5011 ,  C12Q1/48 ,  C12Y201/01043 ,  G01N33/57407 ,  G01N2333/4736 ,  G01N2333/91011 ,  G01N2500/02

公开(公告)号：EP2606133A1

公开(公告)日：2013-06-26

申请号：EP11817936.5

申请日：2011-08-18

Applicant: OncoTherapy Science, Inc.

Inventor： HAMAMOTO, Ryuji ,  NAKAMURA, Yusuke ,  TSUNODA, Takuya

IPC: C12N15/09 ,  A61K31/713 ,  A61P35/00 ,  C12N15/113 ,  G01N33/15 ,  G01N33/50

CPC classification number: G01N33/5011 ,  A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/48 ,  C12Q1/6897 ,  C12Y201/01043 ,  G01N33/57407 ,  G01N33/6872 ,  G01N2500/04

Abstract: The present invention relates to the roles played by the SUV420H1 and SUV420H2 genes in carcinogenesis and features a method for treating or preventing cancer by administering a double-stranded molecule against the SUV420H1 or SUV420H2 gene or a composition or vector containing such a double-stranded molecule. The present invention also features methods and kits for detecting or diagnosing cancer in a subject, including detecting an expression level of the SUV420H1 or SUV420H2 gene. The present invention further features methods and kits for assessing or determining the prognosis of a subject with cancer, including detecting the expression level of an SUV420H2 gene. Also, disclosed are methods of screening for candidate substances for treating or preventing cancer or inhibiting cancer cell growth, using as an index their effect on the expression or activity of SUV420H1 or SUV420H2.