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    ULTRASENSITIVE SPECTROPHOTOMETER
    112.
    发明申请
    ULTRASENSITIVE SPECTROPHOTOMETER 审中-公开
    超声波分光光度计

    公开(公告)号：WO2006076353A2

    公开(公告)日：2006-07-20

    申请号：PCT/US2006/000805

    申请日：2006-01-11

    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI ,  LARSEN, David, W. ,  XU, Zhi

    Inventor： LARSEN, David, W. ,  XU, Zhi

    IPC: G01J3/51

    CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

    Abstract: The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. The level of light source noise in these measurements can be reduced in accordance with the invention. Preferred embodiments of the invention use sealed housings (112, 600, 700) lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing (600, 700) is used. Other features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes, for example, a prism (302, 322, 622a, 623 a) including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface (402, 422) is used instead of a prism. In a diffuse reflection embodiment a matte surface (502, 522) is used instead of a prism and the matte surface produces scattering. Aspects of the invention include identification of noise-contributing components in spectrophotometry and the select set of preferred features in a given embodiment, and noise levels very near the shot noise limit may be realized with application of preferred embodiment devices.

    Abstract translation: 本发明涉及测量光，其中光与引起光强变化的物质相互作用，本发明的优选实施方式的分光光度计装置通过与物质的反射相互作用提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声的水平。 本发明的优选实施例使用缺少内部光源的密封外壳（112,600,700）和基于反射的样品和参考单元。 在一些实施例中，使用基本上固体的导热壳体（600,700）。 优选实施方案的其它特征包括特定的基于反射的样品和参考细胞。 全内反射实施例包括例如包括相互作用表面的棱镜（302,322,622a，623a），检测器，将从棱镜输出的光束聚焦到检测器上的透镜，以及具有 用于将气体或液体输送到相互作用表面的入口和出口。 在镜面反射实施例中，使用反射表面（402,422）代替棱镜。 在漫反射实施例中，使用无光泽表面（502,522）代替棱镜，并且无光泽表面产生散射。 本发明的方面包括在给定实施例中识别分光光度法中的噪声贡献成分以及在一特定实施例中选择的一组优选特征，并且通过应用优选实施例装置可以实现非常接近散粒噪声极限的噪声水平。

    PARTICLE SENSOR
    113.
    发明申请
    PARTICLE SENSOR 审中-公开
    颗粒传感器

    公开(公告)号：WO0173381A3

    公开(公告)日：2002-02-07

    申请号：PCT/JP0102539

    申请日：2001-03-28

    Applicant: MATSUSHITA ELECTRIC WORKS LTD ,  OKA SHOICHI ,  HAYASHI MASANORI ,  KIRIHATA SHINJI ,  NISHIKAWA TAKAYUKI ,  SAKAMOTO KOJI ,  WADA TAKESHI

    Inventor： OKA SHOICHI ,  HAYASHI MASANORI ,  KIRIHATA SHINJI ,  NISHIKAWA TAKAYUKI ,  SAKAMOTO KOJI ,  WADA TAKESHI

    IPC: G01N15/06 ,  G01N21/53 ,  H03G1/00 ,  G01N15/02 ,  H03F1/30 ,  H03F3/45

    CPC classification number: G01N21/53 ,  G01N2201/127 ,  H03G1/0088

    Abstract: A particle sensor has a gain control and an offset voltage adjustment so as to provide a consistent sensor output indicative of the particle density in match with a predetermined relationship between the sensor output and the particle density, while compensating for background noises. The gain control and the offset voltage adjustment are realized respectively by digitally controllable variable resistor networks each having a plurality of switches. A memory module is included in the sensor to store instruction data for control of the switches and therefore responsible for the gain control and the offset voltage adjustment. In particular, the particle sensor includes a memory interface which enables the selective use of two types of memory means, one is an intelligent memory module composed of EEPROM and a microcomputer, and the other is a normal memory module consisting of EEPROM.

    Abstract translation: 颗粒传感器具有增益控制和偏移电压调整，以便在补偿背景噪声的同时，提供指示颗粒密度与传感器输出和颗粒密度之间的预定关系匹配的一致的传感器输出。 增益控制和偏移电压调整分别由具有多个开关的数字可控可变电阻网络实现。 传感器中包含存储器模块以存储用于控制开关的指令数据，因此负责增益控制和偏移电压调整。 特别地，粒子传感器包括能够选择性地使用两种存储装置的存储器接口，一个是由EEPROM和微计算机组成的智能存储器模块，另一个是由EEPROM组成的通常存储器模块。

    CONCENTRATION MEASURING APPARATUS AND METHOD
    115.
    发明申请
    CONCENTRATION MEASURING APPARATUS AND METHOD 审中-公开
    浓度测量仪器和方法

    公开(公告)号：WO1992018849A1

    公开(公告)日：1992-10-29

    申请号：PCT/US1992003181

    申请日：1992-04-16

    Applicant: BAKER HUGHES INCORPORATED

    Inventor： BAKER HUGHES INCORPORATED ,  KIMBELL, Chris, L. ,  HAYMAN, Robert, M. ,  SZINNYEI, W., Jay

    IPC: G01N21/55

    CPC classification number: G01N21/8483 ,  G01N21/783 ,  G01N2201/084 ,  G01N2201/122 ,  G01N2201/127

    Abstract: A concentration measuring apparatus is provided having a reflective sensing media in a self-contained cassette (202), fiber optic line (302, 304) partially associated with a lamp (306) and a photocell (310). A signal is generated by the photocell (310) representative of the charge of reflectivity of the light from the reflective sensing media (600). The signal from the photocell (310) is accepted by a signal processor containing an amplifier (404), an analog to digital converter (430) and computer (480). An interface is associated with the signal processor and comprises a display (520) a 4-to-20 milliamp cord (530) and remote, explosion-proof switches (510) for operator interaction with the concentration measuring apparatus.

    DIGITAL ANESTHETIC AGENT ANALYZER
    116.
    发明申请
    DIGITAL ANESTHETIC AGENT ANALYZER 审中-公开
    数字麻醉剂分析仪

    公开(公告)号：WO1987002460A1

    公开(公告)日：1987-04-23

    申请号：PCT/US1986002150

    申请日：1986-10-10

    Applicant: ANDROS ANALYZERS INCORPORATED

    Inventor： ANDROS ANALYZERS INCORPORATED ,  PARNOFF, George, Kenneth ,  PASSARO, Robert, Eugene ,  ROGERS, Raymond, Earl ,  WILLIAMS, Kevin, Graham

    IPC: G01N21/61

    CPC classification number: G01N21/3504 ,  G01N21/314 ,  G01N2021/3129 ,  G01N2201/127 ,  G01N2201/12723

    Abstract: A gaz analyzer comprising a sample cell (21) for containing a gas mixture to be analyzed, a source (11) for producing and directing infrared energy through the sample cell, a rotary filter wheel (17) having at least one filter thereon for passing infrared energy limited to a wavelength band within the characteristic absorption band of a predetermined gas and having a dark level region substantially opaque to infrared energy, a drive (19, 20) for supporting and rotating the filter wheel to successively interpose the filter and the dark level region between the source and the sample cell in the path (13) of the infrared energy directed by the source, a detector (15) for detecting infrared energy passing through the sample cell and producing an electrical signal representative thereof, and a signal processor (24) connected to the detector means for producing an output indicating the concentration of the predetermined gas in the sample cell by comparing the electrical signals produced by the detector with the filter positioned in the infrared energy path and with the dark level region positioned in the infrared energy path. The dark level region has a substantially fully reflective surface oriented toward the sample cell (21) when positioned in the infrared energy path whereby infrared energy impinging thereon is reflected.

    Abstract translation: 一种包括用于容纳要分析的气体混合物的样品池（21）的gaz分析器，用于产生和引导红外能量通过样品池的源（11），具有至少一个过滤器的旋转滤光轮（17），用于通过 限制在预定气体的特征吸收带内的具有对红外能量基本不透明的暗电平区域的波长带的红外能量;用于支撑和旋转滤光轮以依次插入滤光器和黑暗的驱动器（19,20） 由源极引导的红外能量的路径（13）中的源极和样品池之间的水平区域，用于检测穿过样品池的红外能量并产生表示其的电信号的检测器（15），以及信号处理器 （24），其连接到检​​测器装置，用于通过比较由t产生的电信号来产生指示样品池中预定气体的浓度的输出 他的检测器具有位于红外能量路径中的过滤器，并且暗层区域位于红外能量路径中。 当位于红外能量路径中时，暗电平区域具有朝向样品池（21）定向的基本上完全反射的表面，由此反射其上的红外能量。

    생물학적 장비 보정을 위한 방법 및 시스템
    118.
    发明公开
    생물학적 장비 보정을 위한 방법 및 시스템 审中-实审
    用于生物设备校准的方法和系统

    公开(公告)号：KR1020170134359A

    公开(公告)日：2017-12-06

    申请号：KR1020177025090

    申请日：2016-02-05

    Applicant: 라이프 테크놀로지스 코포레이션

    Inventor： 추,용 ,  막스,제프리 ,  프루덴탈,제이콥 ,  웨셀,토마스 ,  우,데이비드

    IPC: G01N21/27 ,  G01N21/64 ,  C12Q1/68

    CPC classification number: G01N21/6428 ,  C12Q1/6851 ,  C12Q1/686 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/127 ,  G01N2201/13 ,  G01N2333/922

    Abstract: 일구현예에서, 장비를보정하는방법이제공된다. 상기장비는복수의반응부위로부터형광방출을이미징할수 있는광학시스템을포함한다. 상기방법은관심영역(ROI) 보정을수행하여이미지에서반응부위위치를결정하는단계를포함한다. 상기방법은순수염료보정을수행하여형광염료의원시스펙트럼을상기형광염료의순수스펙트럼보정데이터와비교함으로써각각의반응부위에서사용된형광염료의기여도를결정하는단계를더 포함한다. 상기방법은장비정규화보정을수행하여필터정규화계수를결정하는단계를더 포함한다. 상기방법은 RNase P 검증을수행하여상기장비가샘플의서로다른두 개의수량을구별할수 있는지검증하는단계를포함한다.

    Abstract translation: 在一个实施例中，提供了一种校准设备的方法。 该设备包括能够成像来自多个反应位点的荧光发射的光学系统。 该方法包括执行感兴趣区域（ROI）校正以确定图像中反应部位的位置。 该方法包括：通过比较，当荧光染料诊所进行纯染料和荧光染料的光谱纯校正数据的校准光谱进一步确定在每个反应网站所使用的荧光染料的贡献的步骤。 该方法还包括执行设备归一化校正以确定滤波器归一化系数。 该方法包括执行RNase P验证以验证该仪器能够区分两个不同数量的样本。

    결합 염료를 보정하기 위한 시스템 및 방법
    119.
    发明公开
    결합 염료를 보정하기 위한 시스템 및 방법 审中-实审
    用于校准键合染料的系统和方法

    公开(公告)号：KR1020170134358A

    公开(公告)日：2017-12-06

    申请号：KR1020177025088

    申请日：2016-02-05

    Applicant: 라이프 테크놀로지스 코포레이션

    Inventor： 추,용 ,  프루덴탈,제이콥 ,  막스,제프리

    IPC: G01N21/27 ,  G01N21/64 ,  C12Q1/68

    CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/127

    Abstract: 형광염료를보정하기위한컴퓨터구현방법(500)이기술된다. 상기방법(500)은 1개초과의채널에서기구내에적재되는샘플홀더를이미징하는단계를포함한다. 샘플홀더는복수의반응부위및 1개초과의염료유형을포함하고, 각각의염료는 1개초과의반응부위를점유한다. 상기방법은샘플홀더상의각각의염료에대한피크채널을식별하는단계(508), 각각의채널을각각의염료에대한피크채널로정규화하는단계(510) 및염료기준값의세트를포함하는염료행렬을생성하는단계(518)를추가로포함한다.

    Abstract translation: 描述了校正荧光染料的计算机实现的方法（500）。 方法500包括将装载在仪器中的样品架成像在多于一个通道中。 样品架包含多个反应位点和多于一种染料类型，每种染料占据多于一个的反应位点。 该方法包括含有步骤508中，步骤510和一组染料的染料矩阵用于归一化到峰值信道的各个信道为每个染料来识别峰值信道为每个染料对样品保持器参考值 如图5所示，

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