公开(公告)号：WO1990001294A1

公开(公告)日：1990-02-22

申请号：PCT/SE1989000422

申请日：1989-07-28

Applicant: RADISENSOR AB ,  TENERZ, Lars ,  HÖK, Bertil ,  LONC, Roman ,  HAMMARSTRÖM, Ola ,  ENGSTRÖM, Tomas

Inventor： RADISENSOR AB

IPC: A61B05/02

CPC classification number: A61B5/02154 ,  G01L9/0077

Abstract: A miniaturized transducer for in vivo measurements of physiological pressure has a transducer unit (2, 3) and an inner tube (1) with a wall opening (6). A diaphragm (5) covers the wall opening. Distinguishing for the invention is that the diaphragm is protected by an outer tube (8) arranged outside the inner tube, and having a wall opening (9) situated radially opposite the wall opening of the inner tube. An end closure closes off the distal end of the tube and a seal (16) seals the outer tube against the inner tube. The lumen (4) of the inner tube is in communication with the atmospheric pressure.

Abstract translation: 用于体内生理压力测量的小型化传感器具有换能器单元（2,3）和具有壁开口（6）的内管（1）。 隔膜（5）覆盖墙壁开口。 本发明的区别在于，隔膜由布置在内管外部的外管（8）保护，并且具有位于内管的壁开口径向相对的壁开口（9）。 端盖封闭管的远端，并且密封件（16）将外管密封在内管上。 内管的内腔（4）与大气压力相连通。

公开(公告)号：WO1989010089A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001777

申请日：1989-04-27

Applicant: MILLAR INSTRUMENTS, INC.

Inventor： MILLAR INSTRUMENTS, INC. ,  MILLAR, Huntly, D.

IPC: A61B05/02

CPC classification number: A61B5/6851 ,  A61B5/0215

Abstract: An apparatus for sensing in vivo the fluid pressure differential between spaced locations uses a single pressure transducer (34). The transducer has a deformable member (40) mounted to a housing; a conduit (26) extends within the housing (20) with one end (28) opening at a location spaced from the transducer and the other end opening adjoining the inner surface of the member. With the housing inserted in the biological fluid vessel, the outer surface of the deformable member is exposed to the fluid pressure adjacent the member, while the inner surface is exposed to the fluid pressure within the conduit. The deformable member flexes in response to the fluid pressure differential across the member, which is a direct measure of the fluid pressure differential between spaced-apart locations in the fluid-filled vessel. Strain gauges are mounted to the member to generate a signal indicative of the pressure differential, with electrical leads (50) coupled to the strain gauges and received in a catheter threaded in the vessel.

公开(公告)号：WO1989006512A1

公开(公告)日：1989-07-27

申请号：PCT/EP1989000053

申请日：1989-01-17

Applicant: EISENMENGER, Wolfgang ,  STAUDENRAUS, Joachim

IPC: A61B05/02

CPC classification number: A61B17/22012 ,  A61B2090/064 ,  G01H9/004 ,  G01L11/025

Abstract: An optical reflection hydrophonic probe is useful for determining the pressure-time behaviour of pressure waves in fluids. One end of an optical waveguide (glass fibre) dips into the fluid. The reflection of light at the tip of the glass fibre is combined with the pressure amplitude in the fluid by means of the relationship between refractive index and density. This hydrophonic probe can capture pressure signals of high rate of rise and amplitude, and offers long service life and trouble-free performance.

Abstract translation: 光学反射水平探测器可用于确定流体中压力波的压力 - 时间行为。 光波导（玻璃纤维）的一端浸入流体中。 通过折射率和密度之间的关系，将玻璃纤维末端的光的反射与流体中的压力振幅相结合。 该探头可以捕获上升幅度高的压力信号，使用寿命长，无故障的性能。

公开(公告)号：WO1988000810A1

公开(公告)日：1988-02-11

申请号：PCT/SE1987000347

申请日：1987-07-31

Applicant: RADISENSOR AB ,  TENERZ, Lars ,  HÖÖK, Bertil ,  ENGSTRÖM, Thomas

Inventor： RADISENSOR AB

IPC: A61B05/02

CPC classification number: A61B5/6851 ,  A61B5/0215 ,  A61M25/09033 ,  A61M2025/09175

Abstract: The guide wire includes a miniaturised pressure sensor (1), which is disposed at the distal end of the guide wire. The latter also includes a ventilation passage (4, 15) intended to connect the pressure sensor to ambient atmospheric pressure.

Abstract translation: 引导线包括设置在导丝的远端的小型化压力传感器（1）。 后者还包括用于将压力传感器连接到环境大气压力的通风通道（4,15）。

公开(公告)号：WO1987002232A1

公开(公告)日：1987-04-23

申请号：PCT/US1986002036

申请日：1986-10-01

Applicant: GMS ENGINEERING CORPORATION

Inventor： GMS ENGINEERING CORPORATION ,  SAMARAS, George, M. ,  BLAUMANIS, Otis, R. ,  VAN HORN, H., William

IPC: A61B05/02

CPC classification number: A61B5/02141 ,  A61B5/022 ,  A61B5/7239

Abstract: An apparatus and method for non-invasive, noise insensitive blood pressure determination which is useful in a battlefield or emergency vehicle environment. The system features an occlusion bladder (10) and a sensing bladder (12) both adapted to fit over the limb (8) of a patient. The pressure in the occlusion bladder (10) is raised to a value which prevents flow and is then gradually decreased. The pressure in both bladders is monitored. When the pressure in the sensing bladder (12) reaches a minimum value, the pressure in the occlusion bladder (10) is equal to the systolic pressure. The first, second and third time derivatives of the pressure in the sensing bladder are monitored. The first derivative is useful in identifying the minimum in the pressure in the sensing bladder (12). When the third time derivative of the pressure in the sensing bladder (12) passes through zero, the pressure in the occlusion bladder (10) is equivalent to the mean arterial pressure. The diastolic pressure can be calculated from the values of the systolic and mean arterial pressures.

公开(公告)号：WO1985000741A1

公开(公告)日：1985-02-28

申请号：PCT/EP1984000243

申请日：1984-08-10

Applicant: STERIMED GESELLSCHAFT FÜR MEDIZINISCHEN BEDARF ... ,  KRAMANN, Bernhard

Inventor： STERIMED GESELLSCHAFT FÜR MEDIZINISCHEN BEDARF ...

IPC: A61B05/02

CPC classification number: A61B5/02152 ,  A61M5/16854

Abstract: Infusion unit with a device for determining the central venous blood pressure, comprising an infusion bottle (2) and an infusion line (4) wherein is inserted a pressure determination chamber (7), as well as a disconnecting device (8) provided between the infusion bottle (2) and the pressure determination chamber. The pressure determination chamber (7) includes a first readily deformable chamber (27) and a second readily deformable chamber (16), the first chamber (27) being connected to the infusion line (4) and to a vein catheter (5) and the second chamber (16) being connected by a flexible line (14) to the rising pipe (13).

公开(公告)号：WO1984004032A1

公开(公告)日：1984-10-25

申请号：PCT/SU1984000020

申请日：1984-04-13

Applicant: MOSKOVSKY FIZIKO-TEKHNICHESKY INSTITUT ,  2-I MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT ,  VINOGRADOV, Alexei Viktorovich ,  MAKAROVA, Inna Ivanovna ,  ALEXANDROV, Jury Nikolaevich ,  GALAKTIONOV, Viktor Alexandrovich ,  OZERSKY, Jury Pavlovich

Inventor： MOSKOVSKY FIZIKO-TEKHNICHESKY INSTITUT ,  2-I MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT

IPC: A61B05/02

CPC classification number: A61B5/022

Abstract: The method for the examination of the state of a cardiovascular system provides for the determination of quantitative values, which characterize a blood supply occurring in each of examined parts of a body, and which correspond to the sum of absolute values of areas, enclosed by all positive and negative half-cycles formed by the first-order time derivative of a pulsation pressure, which oscillates inside a blood vessel of the examined part of the body. Sums and ratios of said values are computed for sampling populations of the body parts and are compared with the average statistical ranges of the appropriate values, sums and ratios, which were found as typical for both healthy organisms and for organisms having known pathological deviations. Results obtained thereby are interpreted for diagnosing the state of the cardiovascular system. The device comprises channels (5) provided for the measurement of the values characterizing the blood supply, the number of which channels corresponds to the number of the examined parts of the body. Each of the channels comprises an occlusion cuff (2) by which a pressure on the examined body part is exerted through a pneumatic splitter (7) from a source (1) of the variating pressure, a tachooscillation transducer (3) separating the first-order time derivative of the pulsation pressure applied upon the cuff (2), a unit (6) effecting the measurements of the quantitative values of the blood supply and a recording unit (4). The computation of the sums and of the ratios of the quantitative values characterizing the blood supply occuring in the sampling populations of the body parts, as well as their comparison with said average statical ranges is performed by a computing unit (29).

公开(公告)号：WO1984002837A1

公开(公告)日：1984-08-02

申请号：PCT/SE1984000018

申请日：1984-01-19

Applicant: KAROLINSKA INSTITUTET ,  LINNARSSON, Dag ,  LARSSON, Hans

Inventor： KAROLINSKA INSTITUTET

IPC: A61B05/02

CPC classification number: A61B5/0836

Abstract: An arrangement (7) for the non-invasive determination of the minute volume Q of the heart is arranged to determine the amount of a sufficiently soluble gas, e.g. carbon dioxide or nitrous oxide, present in the blood, prior to and subsequent to the passage of the blood through the heart. The expired and inspired gases are separated from one another with each breath taken. Transducers (15, 16, 17) feed respective devices for determining the gas content of the respiration gas (10), and the magnitude of the expiration gas flow (8) and the inspiration gas flow (18). These devices (10, 8, 18) are controlled by a microprocessor (6), which is programmed to supply gas from a gas source (12), to meter the gas during a subsequent inspiration cycle, and to control an indicator (9) for the Q-value. The gas is controlled in a manner such that the gas-content of the lungs is changed in accordance with a given programme. The Q-value is calculated for pairs of respiration cycles in accordance with the formula (I), in which V1 is the effective gas flow/unit time for a respiration cycle; V2 is the effective gas flow/unit time for the next respiration cycle; Ca1 is the gas content of arterial blood for the first respiration cycle; Ca2 is the gas content of arterial blood for the next respiration cycle. The microprocessor (6) is arranged to calculate Q for a plurality of pairs of respiration cycles (e.g. 5 - 6 pairs) with a given number of respiration cycles therebetween (e.g. 4), and to send to the indicator (9) a signal corresponding to the mean value of the Q-values obtained.

公开(公告)号：WO1984001499A1

公开(公告)日：1984-04-26

申请号：PCT/US1982001491

申请日：1982-10-19

Applicant: IVAC CORPORATION

Inventor： IVAC CORPORATION ,  GEORGI, Heinz, W.

IPC: A61B05/02

CPC classification number: A61B5/02225 ,  A61B5/02208 ,  A61B5/7207 ,  A61B5/7239 ,  A61B7/045

Abstract: An electronic method and apparatus for automatically determining systolic and diastolic blood pressures and heart rate by accurately detecting, verifying and evaluating the full stream of korotkoff sounds produced as electrical signals from a microphone (214) in a cuff (200) occluding the brachial artery of a patient and the corresponding blood pressure pulse signals which accompany and are precursors to genuine korotkoff sound signals. Blood pressure is measured with the aid of a programmed data processor (216) such as a microprocessor. Waveform analysis is first performed upon the incoming signal waveforms to initially separate true pressure pulses and korotkoff sound signals from a variety of artifact and noise signals and to provide digital pulse streams in memory correctly indicating proper pressure pulse and korotkoff sound occurrences in the time and blood pressure domains, with each pressure pulse proportional in amplitude to the amplitude of the corresponding detected precursor input pressure signal represented and each korotkoff pulse proportional to the negative slope amplitude of the corresponding detected korotkoff sound. The ouput pulse signal streams are then further analyzed by the digital processing subsystem and compared with each other to additionally remove any noise and artifact signals passed as otherwise misleading genuine signals, to modify and certify the resultant data as either reliable or suspect, to determine heart rate and the most probable values of systolic and diastolic blood pressure levels indicated by the pulse signal streams detected during the measurement cycle.

Abstract translation: 一种电子方法和装置，用于通过精确地检测，验证和评估由闭合肱动脉的袖带（200）中的麦克风（214）产生的作为电信号的柯罗科夫声音的完整流，自动确定心脏收缩压和心率， 一个患者和相应的血压脉冲信号，它们伴随着并且是真正的korotkoff声音信号的前兆。 借助于诸如微处理器的编程数据处理器（216）来测量血压。 波形分析首先根据输入的信号波形进行，以便从各种假象和噪声信号中分离出真实的压力脉冲和korotkoff声音信号，并在存储器中正确提供正确的数字脉冲流，指示适当的压力脉冲和korotkoff声音在时间和血液中的出现 压力域，其中每个压力脉冲在幅度上与所表示的相应检测到的前驱体输入压力信号的幅度成比例，并且每个korotkoff脉冲与相应检测到的korotkoff声音的负斜率幅度成比例。 输出脉冲信号流然后由数字处理子系统进一步分析，并相互比较，以额外消除作为其他误导性真实信号传递的任何噪声和伪影信号，以将可靠或可疑的结果数据修改和证明以确定心脏 速率和在测量周期期间检测到的脉冲信号流指示的最可能的收缩压和舒张压水平值。

公开(公告)号：WO1984000291A1

公开(公告)日：1984-02-02

申请号：PCT/US1983000934

申请日：1983-06-16

Applicant: GOULD INC.

Inventor： GOULD INC. ,  SCHABERG, Richard, R. ,  COLE, James, E.

IPC: A61B05/02

CPC classification number: A61B5/0215 ,  G01L9/006

Abstract: A physiological pressure sensing and monitoring system (10) including a sterile throwaway pressure transducing device (11). The device (11) includes a pressure transducer (16) mounted together with a flow control valve (14) in a housing (12). The device includes a first connector (21) for connecting the device to a source of sterile solution (18), a second connector (28) for electrically connecting the pressure transducer to a monitoring device (26), and a third connector (22) for selectively connecting the device to a catheter (33) inserted into a patient's circulatory system. The device, including the connectors, is made to be low cost so as to permit the entire device to be installed and discarded as a unit so as to constitute a throwaway pressure sensing and flow regulating means. A number of different embodiments of the pressure transducer are disclosed, each of which constitutes a low cost, accurate pressure transducing means arranged to have high electrical isolation relative to the fluid in a pressure chamber (13) of the housing, the pressure of which is continuously sensed by the transducer. In one embodiment, the force collector for transmitting the pressure force to the strain gage (55) is formed as a one-piece unit. In a number of the embodiments, the elements are formed separately and bonded together.