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公开(公告)号：US11352666B2
公开(公告)日：2022-06-07
申请号：US15526528
申请日：2015-11-13
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Jin Soo Kim , Dae Sik Kim , Sang Su Bae
IPC: C12Q1/6874 , C12N9/22 , C12Q1/686 , C12Q1/6806 , G16B30/00 , G16B30/10
Abstract: The present disclosure relates to a method for detecting off-target sites of a programmable nuclease in a genome, and specifically, to a method for detecting off-target sites through data analysis by subjecting the genome isolated in vitro to programmable nucleases to cleave the genome and then performing whole genome sequencing or deep sequencing, and to a method for selecting on-target sites of a programmable nuclease, which minimizes the off-target effect, using this method. The Digenome-seq of the present disclosure can detect the off-target sites of a programmable nuclease on the genomic scale at a high degree of reproducibility, and thus can be used in the manufacture of programmable nucleases having high target specificity and the study thereof.
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122.发明申请公开(公告)号：US20220103733A1
公开(公告)日：2022-03-31
申请号：US17484189
申请日：2021-09-24
Inventor： Won Shik CHOI , Won Jun CHOI , Mun Kyu KANG
Abstract: Disclosed are an endoscopic reflection microscope using an optical fiber bundle and an image acquisition method using the same. The endoscopic reflection microscope includes an incident wave output unit configured to output an incident wave to a target object through any one optical fiber in an optical fiber bundle, a reflected wave receiver configured to receive a reflected wave output from the target object in response to the incident wave through a plurality of corresponding optical fibers in the optical fiber bundle, and an image acquirer configured to establish a reflection matrix corresponding to the reflected wave and to acquire an image in which at least one of phase retardation of the incident wave or phase retardation of the reflected wave is compensated for based on the established reflection matrix.
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123.发明申请公开(公告)号：US20220079515A1
公开(公告)日：2022-03-17
申请号：US17473253
申请日：2021-09-13
Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY , THE TRUSTEES OF DARTMOUTH COLLEGE , INSTITUTE FOR BASIC SCIENCE
Inventor： Choong-Wan WOO , Jae-Joong LEE , Tor D. Wager
Abstract: Disclosed are brain connectivity marker of sustained pain and a method of diagnosing sustained pain using the same. The marker is specific for pain, and does not respond to other noxious stimuli. It can be used for monitoring a pain level and a response to treatment of chronic pain patients, which are considered clinically significant. By comparing a responsive clinical pain group and a non-responsive clinical pain group, the disclosure may be used for differential diagnosis for the cause of pain. The disclosure may be used for pre-screening of a drug clinical trial to dramatically reduce time and costs consumed in trial, and contributes to the development of pain treatment methods such as brain stimulation based on a weight pattern of the marker. The disclosure maybe used to measure a pain level in groups which have difficulty in reporting pain (a vegetative state, aphasia patients, the elderly, infants, etc).
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公开(公告)号：US11149281B2
公开(公告)日：2021-10-19
申请号：US15766445
申请日：2016-10-06
Inventor： Jin Soo Kim , Jungeun Kim , Sunghwa Choe , Je Wook Woo , Soon Il Kwon , Hyeran Kim
Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.
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公开(公告)号：US11123409B2
公开(公告)日：2021-09-21
申请号：US15661300
申请日：2017-07-27
Applicant: INSTITUTE FOR BASIC SCIENCE , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventor： Jin-Soo Kim , Jeong Hun Kim , Sung Wook Park , Kyoungmi Kim
Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.
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Patent Agency Ranking
公开(公告)号：US11085875B2
公开(公告)日：2021-08-10
申请号：US16591664
申请日：2019-10-03
Inventor： Won-Shik Choi , Moon-Seok Kim , Yong-Hyeon Jo , Seok-Chan Yoon
Abstract: The present invention relates to a high-speed imaging system for measuring a target object within a sample, comprising: a light source emitting a plane wave; an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source; an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave and forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object; a camera module obtaining the interference wave, and an imaging controller controlling the angle-adjustment mirror to adjust the angle of the plane wave sequentially, forming a time-gated reflection matrix by using the interference waves obtained by the camera module in accordance with each angle of the plane wave, and imaging the target object based on the time-gated reflection matrix.
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127.发明申请公开(公告)号：US20210191098A1
公开(公告)日：2021-06-24
申请号：US16757470
申请日：2018-10-16
Inventor： Sang Hee SHIM , Ji Woong KWON
Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.
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公开(公告)号：US11013221B2
公开(公告)日：2021-05-25
申请号：US16095414
申请日：2017-04-21
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION , INSTITUTE FOR BASIC SCIENCE , DAEGU GYEONGBUK INSTITUTE OF SCIENCE
Inventor： Hong Gil Nam , Gyoo Yeol Jung , Seung Jae Lee , Woo Seon Hwang , Gi Won Shin , Mi Hwa Seo
IPC: A01K67/033 , G01N33/50 , A01K67/027 , C12N15/85 , A61K49/00 , C12N15/113 , C12N15/89 , C12N15/11
Abstract: The present invention relates to: a transgenic Caenorhabditis elegans in which a glutamine tRNA 5′ terminus-derived fragment (Gln 5′-tsRNA) is overexpressed; a preparation method therefor; and a method for screening for aging-associated factors by using the transgenic Caenorhabditis elegans. A transgenic Caenorhabditis elegans model provided in the present invention is an animal model in which Gln 5′-tsRNA is overexpressed such that aging is inhibited. When the model of the present invention is used, anti-aging mechanisms can be easily investigated, thereby significantly contributing to various research fields such as that of developing new anti-aging drugs and screening for age-inducing materials.
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公开(公告)号：US20210079083A1
公开(公告)日：2021-03-18
申请号：US16995707
申请日：2020-08-17
Inventor： Gou Young Koh , Jeomil Bae , Mi Jeong Kim , Jin-Sung Park , Su Jin Seo , Jaeryung Kim , Jang Ryul Park , Pilhan Kim , Wangyuhl Oh
IPC: C07K16/22 , A61K39/395 , A61K45/06 , A61P35/00
Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention provides an angiogenesis inhibitor and a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.
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公开(公告)号：US20210054267A1
公开(公告)日：2021-02-25
申请号：US16963824
申请日：2019-01-22
Inventor： Hee Cheul CHOI , Jin Young KOO , Minkyung LEE
Abstract: According to the present invention, an organic light-emitting composite and a method of manufacturing the organic light-emitting composite are provided. According to exemplary embodiments, an organic light-emitting composite includes a polymer matrix; a first light-emitting material provided in the polymer matrix; and a second light-emitting material provided in the polymer matrix and obtained by oxidizing the first light-emitting material, wherein the second light-emitting material may have the same molecular weight as that of the first light emitting-material.
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