公开(公告)号：EP2368600B1

公开(公告)日：2016-09-21

申请号：EP11004652.1

申请日：2004-08-12

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： Rigney, Nick ,  Anderson, Dan ,  Lesyna, David ,  Miller, Dan ,  Moyers, Michael ,  Cheng, Chieh ,  Baumann, Mike ,  McAllaster, Steven ,  Slater, Jerry

IPC: A61N5/10 ,  G21F5/02 ,  A61B6/04

CPC classification number: A61N5/107 ,  A61B6/0442 ,  A61B6/4092 ,  A61B6/547 ,  A61B2090/3937 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/1078 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1087 ,  A61N2005/1097 ,  B25J9/1666 ,  G05B15/02 ,  G05B2219/45117

公开(公告)号：EP2758074A2

公开(公告)日：2014-07-30

申请号：EP12834027.0

申请日：2012-09-21

Applicant: Loma Linda University

Inventor： ESCHER, Alan, P.

IPC: A61K39/10

CPC classification number: A61K39/0241 ,  A61K39/0008 ,  A61K49/00 ,  C12N9/1007 ,  C12N9/22 ,  C12N9/506 ,  C12N15/117 ,  C12N15/70 ,  C12N2310/17

Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.

公开(公告)号：EP2345371B1

公开(公告)日：2014-07-16

申请号：EP11157308.5

申请日：2004-08-16

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： Zhu, Yong Hua ,  Kirsch, Wolff, M.

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

公开(公告)号：EP2504039A1

公开(公告)日：2012-10-03

申请号：EP10833987.0

申请日：2010-11-24

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： KIRSCH, Wolff, M. ,  ZHU, Yong, Hua

IPC: A61L15/28

CPC classification number: A61L15/28 ,  A61L2/081 ,  A61L2/14 ,  A61L2/20 ,  A61L15/42 ,  A61L24/0036 ,  A61L24/08 ,  A61L26/0023 ,  A61L31/042 ,  A61L33/08 ,  A61L2400/04 ,  C08L5/08

Abstract: A microfibrillar high molecular weight chitosan-based textile can be used as a hemostat. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan textile. A single or multiple such treatments may be employed. For example, the chitosan textile may be irradiated under nitrogen using γ- irradiation, treated under a nitrogen plasma, or both.

公开(公告)号：EP2483710A1

公开(公告)日：2012-08-08

申请号：EP10821383.6

申请日：2010-10-01

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： BASHKIROV, Vladimir ,  SCHULTE, Reinhard, W.

IPC: G01T1/18

CPC classification number: G01T1/185 ,  G01T1/16 ,  G06F17/5009 ,  G06F19/12

Abstract: Disclosed are systems, devices and methodologies relating to an ion induced impact ionization detector and uses thereof. In certain implementations, the detector can include a dielectric layer having one or more wells. An anode layer defining apertures to accommodate the openings of the wells can be disposed on one side of the dielectric layer, and a cathode such as a solid resistive cathode can be disposed on the other side so as to provide an electric field in each of the wells. Various design parameters such as well dimensions and operating parameters such as pressure and high voltage are disclosed. In certain implementations, such an ion detector can be coupled to a low pressure gas volume to detect ionization products such as positive ions. Such a system can be configured to provide single ion counting capability. Various example applications where the ion detector can be implemented are also disclosed.

公开(公告)号：EP1718147B1

公开(公告)日：2012-03-28

申请号：EP05713806.7

申请日：2005-02-18

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： ZHU, Yong, Hua ,  YANG, Chang, Zheng ,  KIRSCH, Wolff, M.

IPC: A61L15/28

CPC classification number: A61L15/28 ,  A61B17/0057 ,  A61B17/06166 ,  A61B2017/00526 ,  A61B2017/00623 ,  A61B2017/00884 ,  A61B2017/00898 ,  A61L26/0023 ,  A61L2400/04 ,  C08L5/08

Abstract: This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue.

公开(公告)号：EP2368600A1

公开(公告)日：2011-09-28

申请号：EP11004652.1

申请日：2004-08-12

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： Rigney, Nick ,  Anderson, Dan ,  Lesyna, David ,  Miller, Dan ,  Moyers, Michael ,  Cheng, Chieh ,  Baumann, Mike ,  McAllaster, Steven ,  Slater, Jerry

IPC: A61N5/10 ,  G21F5/02 ,  A61B6/04

CPC classification number: A61N5/107 ,  A61B6/0442 ,  A61B6/4092 ,  A61B6/547 ,  A61B2090/3937 ,  A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/1078 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1087 ,  A61N2005/1097 ,  B25J9/1666 ,  G05B15/02 ,  G05B2219/45117

Abstract: A radiation treatment system (100) for accurately delivering radiation to a targeted site within a cancer patient (108) that includes a modular patient support system and a patient positioner (114). The modular patient support system includes a modularly expandable patient pod (200) and at least one immobilization device, such as, for example, a rigid moldable foam cradle (350). The patient pod (200) includes a generally hemi-cylindrical support shell (212) that extends longitudinally between proximal edge (214) and distal edge (216), and transversely between two lateral edge (222, 224). In one embodiment, the lateral edges (222, 224) are tapered to minimize edge effects that result when radiation beams traverse the lateral edges (222, 224).

Abstract translation: 一种辐射治疗系统（100），用于将辐射准确地传送到癌症患者（108）内的目标部位，其包括模块化患者支撑系统和患者定位器（114）。 模块化患者支撑系统包括模块化可扩张的患者容器（200）和至少一个固定装置，例如刚性可模制泡沫支架（350）。 患者荚（200）包括在近侧边缘（214）和远端边缘（216）之间纵向延伸并且横向于两个侧边缘（222,224）之间延伸的大致半圆柱形支撑壳体（212）。 在一个实施例中，横向边缘（222,224）是锥形的，以最小化当辐射束横穿横向边缘（222,224）时产生的边缘效应。

公开(公告)号：EP2364371A1

公开(公告)日：2011-09-14

申请号：EP09828392.2

申请日：2009-11-24

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FILIPPOV, Valeri

IPC: C12Q1/68

CPC classification number: C12Q1/708 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2333/025

Abstract: A method of detecting the presence of specific human papilloma virus and host cell biomarkers associated with head and neck tumors in biological samples, like saliva, blood or biopsy tissue, obtained from a subject.

公开(公告)号：EP1965707B1

公开(公告)日：2011-03-02

申请号：EP06816391.4

申请日：2006-10-05

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： ZHU, Yong Hua ,  KIRSCH, Wolff M.

IPC: A61B17/00 ,  A61B17/02

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/0206 ,  A61B17/3439 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672 ,  A61B2017/00862 ,  A61B2017/00884 ,  A61B2017/00942 ,  A61B2090/037 ,  A61M25/0668 ,  A61M2025/0681

Abstract: A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

公开(公告)号：EP1259168B1

公开(公告)日：2010-09-08

申请号：EP01916245.2

申请日：2001-02-26

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： ZHU, Yong, Hua ,  KIRSCH, Wolff, M.

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00659

Abstract: A patch applicator has an elongate body with an inner lumen and an outer lumen arranged concentrically. First and second connectors are provided and correspond to the inner and outer lumens, respectively. A patch is also provided. In operation, a source of vacuum is connected to the first connector and draws a vacuum through the inner lumen. The inner lumen is then applied to a patch to releasably hold the patch. The patch is advanced within the patient until it is placed on top of and over a wound in tissue. The source of vacuum is then transferred to the second connector and pulls a vacuum through the outer lumen to clear bodily fluid from a field around the wound. After the field is cleared, the source of vacuum is removed and replaced by a source of flowable adhesive. Adhesive is injected through the outer lumen onto the patch and tissue surrounding the patch. The patch applicator holds the patch in place, allowing the adhesive to set. A release rod is advanced through the first connector and through the inner lumen into contact with the patch. The applicator is then removed from the patch, followed by the release rod. Thus, an adhesive patch is attached to close an opening in tissue.