公开(公告)号：EP3322418A1

公开(公告)日：2018-05-23

申请号：EP16825052.0

申请日：2016-07-12

Applicant: Loma Linda University

Inventor： DUERKSEN-HUGHES, Penelope ,  YUAN, Chung-hsiang ,  FILIPPOVA, Maria ,  KRSTENANSKY, John

IPC: A61K31/437 ,  A61K31/4188 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K31/4184 ,  A61K31/522 ,  A61K31/555 ,  A61K31/704 ,  A61K33/24 ,  A61K38/19 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  A61K2300/00

Abstract: Compositions and methods of treatment are provided for preventing cancers caused by high-risk human papilloma viruses (HPV). Cancers amenable to prevention include cervical cancer, head cancers, neck cancers, and oral cancers. The compositions block interaction between HPV 16 E6, one of two major viral oncogenes, and its partners, thereby resensitizing HPV positive cells to apoptosis.

公开(公告)号：EP2364371A1

公开(公告)日：2011-09-14

申请号：EP09828392.2

申请日：2009-11-24

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FILIPPOV, Valeri

IPC: C12Q1/68

CPC classification number: C12Q1/708 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2333/025

Abstract: A method of detecting the presence of specific human papilloma virus and host cell biomarkers associated with head and neck tumors in biological samples, like saliva, blood or biopsy tissue, obtained from a subject.

公开(公告)号：EP1737987B1

公开(公告)日：2010-11-03

申请号：EP04821356.5

申请日：2004-12-08

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FODOR, Istvan

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: C12Q1/705 ,  C12Q1/70 ,  C12Q2525/143

Abstract: A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then detecting the reporter.

公开(公告)号：EP1737987A2

公开(公告)日：2007-01-03

申请号：EP04821356.5

申请日：2004-12-08

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FODOR, Istvan

IPC: C12Q1/70

CPC classification number: C12Q1/705 ,  C12Q1/70 ,  C12Q2525/143

Abstract: A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then detecting the reporter.

公开(公告)号：WO2010060103A1

公开(公告)日：2010-05-27

申请号：PCT/US2009/065796

申请日：2009-11-24

Applicant: LOMA LINDA UNIVERSITY ,  DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FILIPPOV, Valeri

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FILIPPOV, Valeri

IPC: C12Q1/68

CPC classification number: C12Q1/708 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2333/025

Abstract: A method of detecting the presence of specific human papilloma virus and host cell biomarkers associated with head and neck tumors in biological samples, like saliva, blood or biopsy tissue, obtained from a subject.

Abstract translation: 检测从受试者获得的生物样品（例如唾液，血液或活检组织）中与头颈部肿瘤相关的特定人乳头瘤病毒和宿主细胞生物标志物的存在的方法。

公开(公告)号：WO2005076784A3

公开(公告)日：2005-08-25

申请号：PCT/US2004/041455

申请日：2004-12-08

Applicant: LOMA LINDA UNIVERSITY ,  DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FODOR, Istvan

Inventor： DUERKSEN-HUGHES, Penelope J. ,  FILIPPOVA, Maria ,  FODOR, Istvan

IPC: C12Q1/70

Abstract: A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then detecting the reporter.

公开(公告)号：WO2017011473A1

公开(公告)日：2017-01-19

申请号：PCT/US2016/041931

申请日：2016-07-12

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope ,  YUAN, Chung-hsiang ,  FILIPPOVA, Maria ,  KRSTENANSKY, John

IPC: A61K31/437 ,  A61K31/4188 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K31/4188 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04

Abstract: Compositions and methods of treatment are provided for preventing cancers caused by high-risk human papilloma viruses (HPV). Cancers amenable to prevention include cervical cancer, head cancers, neck cancers, and oral cancers. The compositions block interaction between HPV 16 E6, one of two major viral oncogenes, and its partners, thereby resensitizing HPV positive cells to apoptosis.

Abstract translation: 提供组合物和治疗方法，用于预防高危人乳头瘤病毒（HPV）引起的癌症。 适合预防的癌症包括宫颈癌，头部癌症，颈部癌症和口腔癌。 该组合物阻断HPV 16 E6（两种主要病毒致癌基因之一）及其伴侣之间的相互作用，从而将HPV阳性细胞再感染细胞凋亡。

公开(公告)号：WO2008097854A4

公开(公告)日：2008-08-14

申请号：PCT/US2008/052819

申请日：2008-02-01

Applicant: LOMA LINDA UNIVERSITY ,  DUERKSEN-HUGHES, Penelope, J. ,  FILIPPOVA, Maria ,  TUNGTEAKKHUN, Sandy, S. ,  NEIDIGH, Jonathan, W.

Inventor： DUERKSEN-HUGHES, Penelope, J. ,  FILIPPOVA, Maria ,  TUNGTEAKKHUN, Sandy, S. ,  NEIDIGH, Jonathan, W.

IPC: C07K14/47 ,  C07K14/025 ,  C07K7/06 ,  C07K17/02 ,  C07K17/14 ,  C07K19/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/85 ,  A61K38/08 ,  A61K38/17 ,  A61K48/00 ,  C12N15/37

Abstract: The present invention is directed to novel polypeptides and compositions capable of binding to the E6 oncoprotein of human papillomavirus (HPV), and to methods of employing the novel polypeptides and compositions of the invention to treat HPV infection. In one aspect, the invention is directed to expression vectors encoding the polypeptides, which contain an E6-binding domain derived from a fragment of FADD, and to host cells containing the vectors.