公开(公告)号：US11819021B2

公开(公告)日：2023-11-21

申请号：US16500585

申请日：2018-04-04

Applicant: University of Saskatchewan ,  NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Troy Harkness ,  Terra Gayle Arnason ,  Pankaj Bhowmik

IPC: C07K7/08 ,  A01N37/46 ,  C07K4/00 ,  C07K5/08 ,  C07K5/103 ,  C07K7/06 ,  C12N5/073 ,  C12N15/82 ,  A01N63/50 ,  A61P35/00 ,  A61K8/64

CPC classification number: A01N37/46 ,  A01N63/50 ,  A61K8/64 ,  A61P35/00 ,  C07K4/00 ,  C07K5/08 ,  C07K5/1005 ,  C07K7/06 ,  C07K7/08 ,  C12N5/0603 ,  C12N15/8266 ,  C12N15/8267 ,  C12N15/8271 ,  A01N63/50 ,  A01N63/32

Abstract: Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.

公开(公告)号：US20220280595A1

公开(公告)日：2022-09-08

申请号：US17685943

申请日：2022-03-03

Applicant: University of Saskatchewan

Inventor： Deeyagahage Hiruni Kathyana ,  Antonio Ruzzini

IPC: A61K38/10 ,  A61P31/04

Abstract: Described herein are Staphylococcal toxins inspired peptides (STIPs) with antimicrobial activity, compositions and kits comprising the peptides, and use of the peptides to treat microbial infections. Also described are methods of inhibiting or preventing the growth of a microorganism, and methods of treating microbial infections such as bacterial infections including MRSA, and fungal infections including C. albicans.

公开(公告)号：US20220152185A1

公开(公告)日：2022-05-19

申请号：US17434551

申请日：2020-02-28

Applicant: University of Saskatchewan

Inventor： Heather Lynne Wilson ,  Milan Obradovic

IPC: A61K39/02 ,  A61K9/107 ,  C07K14/195 ,  A61P31/04 ,  C12N15/70

Abstract: L intracellularis antigens for use in subunit vaccine compositions to elicit immune responses against L intracellularis infections such as proliferative enteropathy (PE) are described, as well as polynucleotides encoding therefor. Also described are methods for treating and preventing L intracellularis infections.

公开(公告)号：US11331330B2

公开(公告)日：2022-05-17

申请号：US17046164

申请日：2019-05-31

Applicant: University of Saskatchewan

Inventor： Meena Kishor Sakharkar ,  Jian Yang

IPC: A61K31/7048 ,  A61P31/04 ,  A61K31/192

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of tulathromycin and gallic acid for the treatment of a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection or a disease, disorder or condition arising from a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection.

公开(公告)号：US20220003436A1

公开(公告)日：2022-01-06

申请号：US17345852

申请日：2021-06-11

Applicant: University of Saskatchewan ,  Nortek Air Solutions Canada, Inc.

Inventor： Robert Besant ,  Carey Simonson ,  Blake Norman Erb ,  Howard Brian Hemingson

IPC: F24F3/147 ,  F24F12/00 ,  F24F3/14 ,  F28D21/00 ,  F24F1/0007 ,  F24F1/0071

Abstract: An energy exchanger is provided. The exchanger includes a housing having a front and a back. A plurality of panels forming desiccant channels extend from the front to the back of the housing. Air channels are formed between adjacent panels. The air channels are configured to direct an air stream in a direction from the front of the housing to the back of the housing. A desiccant inlet is provided in flow communication with the desiccant channels. A desiccant outlet is provided in flow communication with the desiccant channels. The desiccant channels are configured to channel desiccant from the desiccant inlet to the desiccant outlet in at least one of a counter-flow or cross-flow direction with respect to the direction of the air stream.

公开(公告)号：US20210177465A1

公开(公告)日：2021-06-17

申请号：US17268892

申请日：2019-08-15

Applicant: University of Saskatchewan

Inventor： Geoffrey H.F. JOHNSTON ,  Nima ASHJAEE ,  James Duncan JOHNSTON

IPC: A61B17/68 ,  A61F2/28

Abstract: Implants and methods for stabilizing bone fractures are provided. In one embodiment, the implants are spheres. In another embodiment, the implants are rods. The rods can be used to stabilize peripheral portions of a bone fracture. The rods can be shaped and configured to correspond to the shape of a region of bone against which the rod will be deployed. The rods can be provided with surface features for engaging adjacent rods and/or adjacent regions of bone to further stabilize the rods. The spheres can be inserted to fill a remaining volume of the fracture cavity. The implants can be made from orthobiologic materials.

公开(公告)号：US20210059241A1

公开(公告)日：2021-03-04

申请号：US16768807

申请日：2018-12-03

Applicant: University of Saskatchewan

Inventor： Francois EUDES ,  Jaswant SINGH ,  Kosala RAJAPAKSHA ,  Muhammad ANZAR ,  Gregg P. ADAMS

IPC: A01N1/02

Abstract: This disclosure provides a preserving composition comprising a cholesterol: carrier complex, optionally a cholesterol: cyclodextrin complex (CC complex) and/or a cell permeable antioxidant peptide and a biological buffer and optionally a cryprotectant, wherein the preserving composition is optionally substantially free of animal phospholipid, animal protein and/or animal lipoprotein. The disclosure also provides methods for the use of the preserving composition in cryopreservation of semen or sperm cells. Also provided is a kit comprising the preserving composition having a CC complex, a biological buffer, a cryoprotectant, a carbohydrate, a pH stabilizer, an antibiotic or antibiotic cocktail and/or a cell permeable anti-oxidant peptide.

公开(公告)号：USRE48254E1

公开(公告)日：2020-10-13

申请号：US14551314

申请日：2014-11-24

Applicant: University of Saskatchewan

Inventor： Al E Slinkard ,  Albert Vandenberg ,  Frederick A. Holm

IPC: A01H1/00 ,  A01H5/00 ,  A01H5/10 ,  C12N9/88 ,  C12N15/82

Abstract: The present invention is directed to lentil plants having increased resistance to an imidaizolinone herbicide. One such plant described herein is the RH44 lentil variety. The present invention also includes seeds produced by these lentil plants and methods of controlling weeds in the vicinity of these lentil plants.

公开(公告)号：US10791960B2

公开(公告)日：2020-10-06

申请号：US15579524

申请日：2016-06-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Darryl Adamko ,  Anas El-Aneed

IPC: G01N33/493 ,  G01N33/68 ,  A61B5/08 ,  G16H10/40 ,  G16H50/20 ,  G16H50/70 ,  G16H20/10

Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.

公开(公告)号：US10718000B2

公开(公告)日：2020-07-21

申请号：US16051701

申请日：2018-08-01

Applicant: National Research Council of Canada ,  University of Saskatchewan

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12N15/70 ,  C12N15/81 ,  C12P17/06 ,  C12N15/52 ,  C12P7/22

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.