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公开(公告)号:WO2023003934A1
公开(公告)日:2023-01-26
申请号:PCT/US2022/037680
申请日:2022-07-20
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: ZHANG, Haichong , GAO, Shang
Abstract: A photoacoustic imaging approach identifies, concurrently with ablation therapy, an extent of the ablation by measuring and rendering a necrotic extent of treated tissue in a treatment region. Laser pulsed light directed at the treatment region induces an acoustic (ultrasound) signal for differentiating ablated tissue from its non-ablative counterpart based on a photoacoustic spectrum variation. The acoustic signal indicates a range of necrotic extent based on a quantified ablated tissue contrast and a total contrast of both necrotic and non-necrotic tissue, defined as a fraction for computing a degree of necrosis. Generation of an image indicating the degree of necrosis allows continuous or near continuous feedback for ablation therapy guidance to ensure complete and effective ablation of the proper tissue in the treatment region.
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公开(公告)号:WO2022240980A1
公开(公告)日:2022-11-17
申请号:PCT/US2022/028757
申请日:2022-05-11
Inventor: GU, Anne , NYCZ, Christopher J. , TAVAKKOLMOGHADDAM, Farid
IPC: A61B1/00 , A61B1/005 , A61B1/00105 , A61B1/0051 , A61B1/0052 , A61M25/0113 , A61M25/0136
Abstract: A steerable medical device, such as an endoscope of an endoscopic system, including a handle and an elongate shaft extending distally from the handle to a distal tip, a motor control assembly including a motor control housing configured to detachably interface with the handle, wherein the motor control assembly includes a first motor disposed within the motor control housing and a first gear assembly disposed within the motor control housing, and a first drive axle configured to engage the first gear assembly with a first deflection mechanism disposed within the handle, the first deflection mechanism being configured to deflect the distal tip in a first plane.
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公开(公告)号:WO2022197805A1
公开(公告)日:2022-09-22
申请号:PCT/US2022/020552
申请日:2022-03-16
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: POPOVIC, Marko B. , STRAUSS, Andrew , BUCCOWICH, Mia , FAY, Brian
Abstract: A prosthetic device and approach for amputee remediation addresses partial or complete replacement of digits, and leverages the use of the remaining functional digits for directing operation of the prosthetic digits. A complete prosthetic digit replaces an amputated digit from actuated movement driven by an adjacent functional digit. A partial amputation leverages residual movement from the remining digit portion as input to an actuator for amplifying the intent of the input through a motorized actuator to impart movement to the prosthetic digit. A wrist harness supports the apparatus of partial and complete prosthetic digits as a single appliance. A variable compression feature augments tension on the wrist harness to tightly engage the prosthetic appliance to the wrist to offset a gripping load on the prosthetic digits.
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公开(公告)号:WO2022197779A1
公开(公告)日:2022-09-22
申请号:PCT/US2022/020514
申请日:2022-03-16
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: POWELL, Adam C. , SU, Hongyi , SHAHABI, Mahya , ZHONG, Yu
IPC: H01M12/06 , H01M10/613 , H01M8/04089 , H01M8/0662 , H01M6/52 , H01M4/02
Abstract: A metal-air battery and methods for generating electricity in a metal-air battery are described herein. The battery and the method includes heating an anhydrous salt to obtain a molten salt electrolyte; contacting the molten salt electrolyte to at least one cathode communicating with air; reducing air at the cathode to obtain oxygen ions for diffusing through the molten salt electrolyte; oxidizing at least one metal anode by the oxygen ions in the electrolyte thereby generating electricity and forming a metal anode oxide; and cooling at least one section of the metal-air battery for precipitating the metal anode oxide.
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公开(公告)号:WO2022170036A1
公开(公告)日:2022-08-11
申请号:PCT/US2022/015223
申请日:2022-02-04
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: BUTLER, Elizabeth A.
Abstract: An oxygen catheter for veterinary patients includes an integrated catheter, cannula or vessel having integrated lumens for both oxygen and anesthetic such as lidocaine. The oxygen lumen extends into the trachea of the veterinary patient, often a canine, for respiratory aid. The anesthetic lumen is integrated into the same catheter as the oxygen, and terminates prior to the oxygen lumen for administering an anesthetic such as lidocaine around the soft palate to ease discomfort of the inserted catheter. The integration of the respiratory and anesthetic vessels allows a lidocaine drip to accompany the catheterized oxygen supply to medicate the tracheal, pharynx and soft palate regions from the inserted catheter along the path of the oxygen lumen to ease patient discomfort and anxiety for effective respiratory treatment while avoiding more invasive and expensive measures.
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公开(公告)号:WO2022164994A1
公开(公告)日:2022-08-04
申请号:PCT/US2022/014043
申请日:2022-01-27
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: POWELL, Adam C. , DAVIS, Boyd , PAL, Uday Bhanu , ZHONG, Yu , FARIA, Christian , ONO, Naoki , INOZUME, Takeshi , ENDO, Chiaki , MIYAUCHI, Tomoya
IPC: H01M8/1213 , H01M4/38
Abstract: Devices and methods for generating electricity in a direct carbon fuel cell are provided herein. The method includes heating and melting an alloy to obtain a liquid alloy anode; circulating the liquid alloy anode through a porous ceramic cathode, the cathode being a tubular structure and in communication with oxygen; reducing the oxygen at the porous cathode to obtain oxygen ions for diffusing through an electrolyte to the liquid alloy anode; and oxidizing the oxygen ions at the liquid alloy anode thereby generating electricity. The direct carbon fuel cells have high electronic conductivity, high carbon solubility with fast carbon diffusion, lower viscosity and eutectic temperatures, and rapid fuel dissolution kinetics.
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公开(公告)号:WO2022115368A1
公开(公告)日:2022-06-02
申请号:PCT/US2021/060305
申请日:2021-11-22
Inventor: NYCZ, Christopher J. , ALBRECHT, Elizabeth M. , CHROBAK, Megan , GHAZI, Kianoosh , FISCHER, Gregory Scott , CLARK, Bryan Allen
Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.
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公开(公告)号:WO2021222645A1
公开(公告)日:2021-11-04
申请号:PCT/US2021/029996
申请日:2021-04-29
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: KAUFMAN, Jesse , TARABEIN, Karim A. , DOWNEY, Cameron W.
IPC: A61B17/32
Abstract: A surgical rongeur device has an interchangeable, locking tip at a cutting end for engageable replacement with a variety of cutting tips for facilitating sterilization and blade changes. A detachable linkage between a handle portion and an interchangeable cutting tip (tip) provides a strong connection for actuation by the handle end but allowing for tip replacement via slidable, lateral displacement of the tip. The tip includes a blade and footplate formed from an amorphous metal for longevity and strength advantages. A handle provides a lever to actuate the tip from slidable communication via the detachable linkage. An interlocking member extends longitudinally from the handle into an internal slot on the tip for locking the tip by preventing lateral movement out of alignment with the handle. The aligned tip is responsive to actuation from the handle via a rail for disposing the blade longitudinally against the footplate.
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公开(公告)号:WO2021087372A1
公开(公告)日:2021-05-06
申请号:PCT/US2020/058380
申请日:2020-10-30
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: SOBOYEJO, Winston O. , OBAYEMI, John D. , SALIFU, Ali A. , UZONWANNE, Vanessa O.
Abstract: Aspects of the disclosure relate to compositions comprising Luteinizing Hormone Releasing Hormone (LHRH) or an analog of LHRH conjugated to paclitaxel, and methods of treatment of cancer, for example, triple negative breast cancer, using such compositions.
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130.
公开(公告)号:WO2021022098A1
公开(公告)日:2021-02-04
申请号:PCT/US2020/044360
申请日:2020-07-30
Applicant: WORCESTER POLYTECHNIC INSTITUTE
Inventor: POWELL, Adam, Clayton, IV , DUSSAULT, David , EARLAM, Matthew , TAJIMA, Aaron , RAYMES, Connor
Abstract: Method and apparatus are provided for efficient metal distillation, and for related primary product process. Vertically stacked and gravity-driven evaporators and condensers are employed to distill metals, such metals having different volatilities. A multiple-effect thermal system of magnesium and other volatile metals is used to efficiently distill and separate metals from multiple metal alloys.
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