公开(公告)号：WO2023003934A1

公开(公告)日：2023-01-26

申请号：PCT/US2022/037680

申请日：2022-07-20

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： ZHANG, Haichong ,  GAO, Shang

IPC: A61B5/00 ,  A61B90/00 ,  A61B18/00

Abstract: A photoacoustic imaging approach identifies, concurrently with ablation therapy, an extent of the ablation by measuring and rendering a necrotic extent of treated tissue in a treatment region. Laser pulsed light directed at the treatment region induces an acoustic (ultrasound) signal for differentiating ablated tissue from its non-ablative counterpart based on a photoacoustic spectrum variation. The acoustic signal indicates a range of necrotic extent based on a quantified ablated tissue contrast and a total contrast of both necrotic and non-necrotic tissue, defined as a fraction for computing a degree of necrosis. Generation of an image indicating the degree of necrosis allows continuous or near continuous feedback for ablation therapy guidance to ensure complete and effective ablation of the proper tissue in the treatment region.