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121.发明公开(-)카테친, (-)에피카테친 갈레이트 및 (-)갈로카테친을 함유하는 피부 미용, 성형용, 및 당뇨병 예방 또는 치료용 조성물 无效用于改善糖尿病的组合物和用于促进人间质干细胞分化成含有（ - ）卡培喹的（ - ）环磷酰胺，（ - ）GALLOCATECHIN
公开(公告)号：KR1020100025045A
公开(公告)日：2010-03-09
申请号：KR1020080083645
申请日：2008-08-27
Applicant: (주)아모레퍼시픽
IPC: A61K31/353 , A61P3/10
Abstract: PURPOSE: A medicinal composition for preventing or treating diabetes and plastic surgery is provided to promote adipocyte differentiation and to enhance volume and elasticity of skin. CONSTITUTION: A medicinal composition for promoting differentiation of adipocytes contains (-)catechin, (-)epicatechin gallate, or (-)gallocatechin as an active ingredient. Adipocyte is human bone marrow mesenchymal stem cell. The (-)catechin, (-)epicatechin gallate, or (-)gallocatechin is isolated from green tea. A medicinal composition for treating and preventing type II diabetes and diabetes complication contains the (-)catechin, (-)epicatechin gallate, or (-)gallocatechin.
Abstract translation: 目的：提供用于预防或治疗糖尿病和整形手术的药物组合物，以促进脂肪细胞分化并增强皮肤的体积和弹性。 构成：用于促进脂肪细胞分化的药用组合物含有（ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素素作为活性成分。 脂肪细胞是人骨髓间充质干细胞。 （ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素可与绿茶分离。 用于治疗和预防II型糖尿病和糖尿病并发症的药物组合物含有（ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素。
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公开(公告)号：KR1020100000392A
公开(公告)日：2010-01-06
申请号：KR1020080059873
申请日：2008-06-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K31/352 , A61Q19/00
Abstract: PURPOSE: A method and composition for promoting skin regeneration using icariside II is provided to promote proliferation of transient amplifying cells of epidermis base and promote skin regeneration. CONSTITUTION: An icariside II of chemical formula 1 promotes proliferation of skin cells in skin cells. The skin cell is transient amplifying cells(TA cells). A composition for promoting skin regeneration contains the icariside II as an active ingredient. The content of the active ingredient is 0.001-10 weight% based on total weight. The composition regenerates epidermis by promoting proliferation of the TA cells. The composition increases the number of TA cells which express CD71 protein (Cluster of Differentiation 71 Protein) and α6 integrin. The composition increases the expression of CD200(Cluster of Differentiation 200).
Abstract translation: 目的：提供使用艾司替丁II促进皮肤再生的方法和组合物，以促进表皮碱基瞬时扩增细胞的增殖并促进皮肤再生。 构成：化学式1的阿奇瑞德II促进皮肤细胞中皮肤细胞的增殖。 皮肤细胞是瞬时扩增细胞（TA细胞）。 用于促进皮肤再生的组合物含有作为活性成分的阿魏酸二酯。 活性成分的含量为0.001-10重量％。 该组合物通过促进TA细胞的增殖而再生表皮。 该组合物增加表达CD71蛋白（分化蛋白簇71）和α6整联蛋白的TA细胞的数量。 该组合物增加CD200（分化群集200）的表达。
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公开(公告)号：KR1020090123049A
公开(公告)日：2009-12-02
申请号：KR1020080048930
申请日：2008-05-27
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6883 , C12Q2600/136
Abstract: PURPOSE: A biomarker of which expression is specifically decreased or suppressed in the sensitive skin is provided to quickly diagnose sensitive skin and used for screening a relieving agent. CONSTITUTION: A biomarker for diagnosing sensitive skin contains gene of which expression is decreased or increased in the sensitive skin compared to healthy skin or a protein encoding the gene. A method for screening a relieving agent of sensitivity comprises: a step of conjugating a candidate agent to a protein encoded by a gene of which expression is increased or decreased in the sensitive skin; and a step of confirming the suppression of protein activity.
Abstract translation: 目的：提供敏感皮肤中特异性降低或抑制表达的生物标志物，以快速诊断敏感皮肤并用于筛选缓解剂。 构成：与健康皮肤或编码该基因的蛋白质相比，用于诊断敏感皮肤的生物标志物含有敏感皮肤中表达降低或增加的基因。 用于筛选敏感性缓释剂的方法包括：将候选试剂与由敏感皮肤中表达增加或减少的基因编码的蛋白质缀合的步骤; 以及确认蛋白质活性抑制的步骤。
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124.发明公开아라키도닐 도파민을 함유하는 지방세포 분화 억제 및지방세포 내의 지질체 수준 감소용 약학 조성물 有权含有ARACHIDONYL DOPAMINE的药物组合物，用于抑制ADIPOCYTE中ADIPOCYTE的分化和降低水平的降低水平
公开(公告)号：KR1020090119159A
公开(公告)日：2009-11-19
申请号：KR1020080045032
申请日：2008-05-15
Applicant: (주)아모레퍼시픽
IPC: A61K31/202 , A61P3/04
CPC classification number: A61K31/202 , A61K9/0019 , A61K9/08 , A61K9/20 , A61K9/48
Abstract: PURPOSE: A pharmaceutical composition for suppressing adipocyte differentiation and reducing lipid droplet is provided to prevent or treat obesity or lipoma. CONSTITUTION: A pharmaceutical composition of adipocyte differentiation contains arachidonyl dopamine. The pharmaceutical composition prevents adipose tissue enlargement-related disease. The adipose tissue enlargement-related disease is obesity or lipoma. The differentiation of adipocyte is from mesenchymal stem cell to adipocyte. The mesenchymal stem cell is human bone marrow mesenchymal stem cell. A formulation of oral administration is used in the form of pill, powder, suspension, emulsion, syrup, and granule.
Abstract translation: 目的：提供抑制脂肪细胞分化和降低脂滴的药物组合物，以预防或治疗肥胖或脂肪瘤。 构成：脂肪细胞分化的药物组合物含有花生四烯多巴胺。 该药物组合物防止脂肪组织扩大相关疾病。 脂肪组织增生相关疾病是肥胖或脂肪瘤。 脂肪细胞的分化是从间充质干细胞到脂肪细胞。 间充质干细胞是人骨髓间充质干细胞。 口服给药的制剂以丸剂，粉剂，悬浮液，乳剂，糖浆剂和颗粒剂的形式使用。
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公开(公告)号：KR101859500B1
公开(公告)日：2018-05-21
申请号：KR1020100121220
申请日：2010-12-01
Applicant: (주)아모레퍼시픽
Abstract: 본발명은콜라겐 4, 라미닌, 니도젠및 프로테오글라이칸을포함하는 3차원매트릭스용조성물및 상기조성물을이용하여제조한 3차원매트릭스를개시한다. 또한본 발명은상기 3차원매트릭스를이용하여세포를배양하는방법을개시한다.
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Patent Agency Ranking
公开(公告)号：KR101859499B1
公开(公告)日：2018-05-21
申请号：KR1020100120373
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/06 , A61K31/728 , A61K35/12 , A61K8/64 , A61Q19/08
Abstract: 본발명은글리신-프롤린-하이드록시프롤린(Gly-Pro-Hyp)으로구성된트리펩타이드, 저분자량히알루론산, 미네랄및 비타민을유효성분으로함유하는지방유래줄기세포의줄기세포성증진용조성물을제공한다. 본발명의조성물은지방유래줄기세포의줄기세포성을증진시킴으로써미용또는성형목적의지방조직증가에유용하다. 그래서, 본발명의조성물은피부볼륨감을증진시키고, 지방유래줄기세포재생을촉진시키고손상된피하지방의기능을회복시켜주므로피부볼륨감증진용미용또는성형용조성물로활용가능하고, 피부외용제조성물로활용가능하다.
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公开(公告)号：KR101785347B1
公开(公告)日：2017-10-17
申请号：KR1020100115853
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158
Abstract: 본발명은피부세포에시험물질을처리하는단계; 및상기단계의시험물질을처리한피부세포에서 DUOX 1 유전자의상대적발현정도를확인하는단계를포함하는피부세포분화촉진물질스크리닝방법을개시한다. 또한피부세포에서의 DUOX 1 유전자상대적발현정도를확인할수 있는장치를포함하는피부세포분화촉진물질스크리닝키트를개시한다. 그리고 DUOX 1 유전자의발현을증가시키는물질을유효성분으로포함하는피부세포분화촉진, 피부보습, 피부장벽기능강화또는아토피증상경감또는치료용조성물을개시한다.
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公开(公告)号：KR101766394B1
公开(公告)日：2017-08-09
申请号：KR1020170080224
申请日：2017-06-26
Applicant: (주)아모레퍼시픽
Abstract: 본발명은하이페리쿰추출물을유효성분으로함유하는지방유래줄기세포의줄기세포성증진용조성물및 피부세포증식용조성물을제공한다. 본발명의하이페리쿰추출물을유효성분으로함유하는조성물은지방유래줄기세포재생을촉진시키고표피의재생에관여하는피부표피기저층의전이-증폭세포의증식을촉진시켜, 피부볼륨감을증진시키고손상된피하지방의기능을회복시켜주므로, 피부볼륨감증대용피부미용및 성형용조성물및 피부볼륨감증대용피부외용제조성물에적용가능하다.
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公开(公告)号：KR101723480B1
公开(公告)日：2017-04-06
申请号：KR1020150134314
申请日：2015-09-23
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K36/534 , A61K8/02 , A61K9/00 , A61Q19/00
Abstract: 본발명은인간중간엽줄기세포의지방세포로의분화를촉진하는조성물에관한것으로, 보다상세하게는건율, 권백, 노회, 단삼, 박하, 반하, 소맥, 어성초, 원지및 조각인추출물중 1종이상을유효성분으로함유하여인간중간엽줄기세포를지방세포로분화하는것을촉진시킴으로써지방체(Lipid droplet)를생성하여, 특정부위의피부의볼륨감을증대시키는미용또는성형용조성물에관한것이다.
Abstract translation: 本发明涉及一种组合物用于促进人类的间充质干细胞的脂肪细胞的分化，并且更具体geonyul，卷柏春天，classis，丹参，薄荷，相反，小麦，蕺，原纸和提取物的片的至少一个 通过含有eulyu晓星分钟通过创建一个局部对象（脂滴）促进人间充质干细胞的脂肪细胞分化，它涉及一种用于化妆品或成形，以增加所述特定区域的皮肤的体积感的组合物。
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