PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE
    122.
    发明申请
    PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE 审中-公开
    脉冲药物释放系统,其制剂和使用方法

    公开(公告)号:WO2008094219A2

    公开(公告)日:2008-08-07

    申请号:PCT/US2007020072

    申请日:2007-09-15

    Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damages or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

    Abstract translation: 描述了液体雾化器装置,系统和制剂组合物,以及用于雾化,气溶胶递送这种组合物的系统,用于将药物气溶胶施用和吹入哺乳动物的肺部系统。 雾化装置和系统可以有效地雾化药液载体的各种粘度,包括由油,水或油和水的乳液组成的药物载体。 溶解或悬浮在本文所述和适用的组合物和制剂中的药物在使用所述雾化器时不会被雾化过程所损害或变性。 此外,雾化系统本身可以适用于机械辅助肺通气系统以及用于肺部药物递送的手持式吸入器和鼻/口罩。

    BUILD-UP RESISTANT AIR ATOMIZING SPRAY NOZZLE ASSEMBLY
    123.
    发明申请
    BUILD-UP RESISTANT AIR ATOMIZING SPRAY NOZZLE ASSEMBLY 审中-公开
    建筑耐火空气喷射喷嘴组件

    公开(公告)号:WO2006026312A3

    公开(公告)日:2007-07-05

    申请号:PCT/US2005030147

    申请日:2005-08-25

    Inventor: HUFFMAN DAVID C

    CPC classification number: B05B7/0441 B05B1/26 B05B1/34 B05B7/0892

    Abstract: A spray nozzle assembly is provided. The spray nozzle assembly includes a nozzle body having a liquid passage that terminates in a nozzle body orifice. The spray nozzle assembly includes an impingement element having an impingement surface spaced from the nozzle body orifice. One or more air outlet orifices are disposed upstream of the impingement surface and oriented to discharge a substantially tubular curtain of air around the nozzle body orifice. An air cap defines a chamber extending around and downstream of the impingement surface. The air cap has a plurality of discharge orifices. At least one of the discharge orifices in the air cap has an associated nipple that is integrally connected to the air cap and extends the discharge orifice outwardly away from an outer face of the air cap.

    Abstract translation: 提供喷嘴组件。 喷嘴组件包括具有终止于喷嘴体孔口的液体通道的喷嘴体。 喷嘴组件包括具有与喷嘴体孔口间隔开的冲击表面的冲击元件。 一个或多个空气出口孔设置在冲击表面的上游并且被定向成排出围绕喷嘴体孔口的基本上管状的空气幕。 气帽限定了在冲击表面周围和下游延伸的腔室。 空气帽具有多个排放孔。 空气帽中的至少一个排放口具有与空气帽一体地连接的相关联的接头,并将排出孔向外远离空气帽的外表面延伸。

    IMPROVED INTERNAL MIX AIR ATOMIZING NOZZLE ASSEMBLY
    124.
    发明申请
    IMPROVED INTERNAL MIX AIR ATOMIZING NOZZLE ASSEMBLY 审中-公开
    改进的内部混合空气喷射喷嘴组件

    公开(公告)号:WO2006023884A3

    公开(公告)日:2006-06-22

    申请号:PCT/US2005029865

    申请日:2005-08-23

    CPC classification number: B05B7/0466 B05B7/0475 B05B7/0892

    Abstract: An internal mix spray nozzle assembly adapted for operation with lesser pressurized air requirements. The spray nozzle assembly includes a liquid passage for directing a liquid flow stream against an impingement pin, and an air guide is provided for forming an annular pressurized air passage about the liquid flow stream for striking and atomizing a laterally spreading dispersion of liquid from the impingement surface. For enhancing liquid atomization, the air guide defines a relatively narrow width air flow opening for substantially accelerating and increasing the pressure of the atomizing air stream, and the impingement pin is formed with a relatively large primary impinging surface and a parallel downstream secondary impingement surface that facilitates further liquid particle breakdown and prevents the accumulation of liquids about the bottom of the impingement pin.

    Abstract translation: 内部混合喷嘴组件,适于以较小的加压空气要求运行。 喷嘴组件包括用于将液体流动流引导到冲击销的液体通道,并且提供空气引导件用于围绕液体流动流形成环形加压空气通道,用于撞击和雾化来自冲击的液体的横向扩散分散体 表面。 为了增强液体雾化,空气引导件限定了相对窄的宽度的气流开口,用于基本上加速和增加雾化空气流的压力,并且冲击销形成有相对较大的主要冲击表面和平行的下游次级冲击表面, 促进进一步的液体颗粒击穿并防止液体围绕撞击销的底部积聚。

    MODULARES DÜSENSYSTEM ZUR ERZEUGUNG VON TROPFEN AUS FLÜSSIGKEITEN UNTERSCHIEDLICHER VISKOSITÄT
    125.
    发明申请
    MODULARES DÜSENSYSTEM ZUR ERZEUGUNG VON TROPFEN AUS FLÜSSIGKEITEN UNTERSCHIEDLICHER VISKOSITÄT 审中-公开
    模块化系统JETS用于生产液体的粘度不同滴

    公开(公告)号:WO2005118150A1

    公开(公告)日:2005-12-15

    申请号:PCT/EP2005/002323

    申请日:2005-03-04

    CPC classification number: B05B7/0892 B05B1/18 B05B7/066 B05B7/0876

    Abstract: Die Erfindung bezieht sich auf ein modular aufgebautes Düsensystem mit dessen Hilfe Tropfen aus Flüssigkeiten unterschiedlicher Viskosität erzeugt werden können. Kernstück: der Erfindung sind Mehrfachanordnungen von Einzeldüsen ohne bewegte Teile, die untereinander in Verbindung stehen und Einzelmodule bilden. Dieser Aufbau ermöglicht ein einfaches Erweitern und Anpassen des Systems wodurch eine maximale Flexibilität gewährleistet wird.

    Abstract translation: 本发明涉及一种模块化喷嘴系统具有可从不同的粘度的液体中产生的液滴的助剂。 芯:本发明是各个喷嘴的多种布置没有运动部件,它们是相互连接,并形成单独模块。 这种结构可以很容易地扩展和定制系统提供了最大的灵活性得到保证。

    INTERNAL MIX AIR ATOMIZING SPRAY NOZZLE ASSEMBLY
    126.
    发明申请
    INTERNAL MIX AIR ATOMIZING SPRAY NOZZLE ASSEMBLY 审中-公开
    内部混合气体喷射喷嘴组件

    公开(公告)号:WO2003095097A1

    公开(公告)日:2003-11-20

    申请号:PCT/US2003/014186

    申请日:2003-05-07

    Abstract: A nozzle for atomizing and spraying liquid is provided. The nozzle includes a longitudinal liquid flow passageway (12) that terminates in a liquid orifice for directing a stream of liquid along a predetermined axis. A plurality of intersecting, transverse passageways (15) extend perpendicular to and intersect the predetermined axis. Each of the transverse passageways terminates at either end in an outlet. The transverse passageways (15) define a first impingement surface downstream of the liquid orifice for breaking up a stream of liquid impinging thereon into a laterally spreading dispersion which disperses through the transverse passageways. An air annulus (24) is arranged in surrounding relation to the outlets of the transverse passageways and oriented to discharge air in a downstream direction so as to strike the fluid dispersed through the outlets of the transverse passageways (15). An expansion chamber (29) is arranged downstream of the transverse passageways and air annulus. The expansion chamber communicates with a nozzle discharge orifice (30).

    Abstract translation: 提供了用于雾化和喷射液体的喷嘴。 喷嘴包括纵向液体流动通道(12),其终止于液体孔口中,用于沿预定轴线引导液流。 多个相交的横向通道(15)垂直于预定轴线并与之相交。 每个横向通道在出口处的任一端终止。 横向通道(15)限定在液体孔口下游的第一冲击表面,用于将其上撞击的液体流分解成横向扩散的分散体,其通过横向通道分散。 空气环(24)围绕横向通道的出口被设置成围绕下游方向排出空气,以便冲击通过横向通道(15)的出口分散的流体。 膨胀室(29)布置在横向通道和空气环的下游。 膨胀室与喷嘴排出口(30)连通。

    APPARATUS COMPRISING A PNEUMOACOUSTIC ATOMIZER
    127.
    发明申请
    APPARATUS COMPRISING A PNEUMOACOUSTIC ATOMIZER 审中-公开
    装置包括一个PNEUMOACOUSTIC ATOMIZER

    公开(公告)号:WO2003030995A2

    公开(公告)日:2003-04-17

    申请号:PCT/US2002/032595

    申请日:2002-10-11

    IPC: A62D

    Abstract: A fire-suppression apparatus that includes a pneumoacoustic atomizer for delivering a mist of liquid (e.g., water) in the form of droplets having a size in the range of about 50 to 90 microns. The mist is suspended in a fire-suppressing gas such as nitrogen. Gas is supplied to the pneumoacoustic atomizer from a system that, in some embodiments, includes both bottles and a gas generator. To minimize consumption of fire-suppressing materials, the fire-suppression apparatus can be operated in a pulsed mode wherein delivery of fire-suppressing materials is interrupted unless a sensor detects a fire re-flash. In some variations, the pneumoacoustic atomizer operates at very low pressures, as is desirable for use in aircraft.

    Abstract translation: 一种灭火装置,其包括用于输送尺寸在约50至90微米范围内的液滴形式的液体雾(例如水)的气声雾化器。 雾气悬浮在氮气等阻火气体中。 气体由系统提供给气声雾化器,该系统在一些实施例中包括瓶子和气体发生器。 为了最大限度地减少消防材料的消耗,防火装置可以以脉冲模式操作,其中防火材料的输送被中断,除非传感器检测到再次闪光​​。 在一些变型中,气声雾化器在非常低的压力下操作,如在飞行器中所需要的那样。

    DEVICE FOR THE MIXING AND SUBSEQUENT ATOMIZING OF LIQUIDS
    128.
    发明申请
    DEVICE FOR THE MIXING AND SUBSEQUENT ATOMIZING OF LIQUIDS 审中-公开
    设备混合和随后散布液

    公开(公告)号:WO99033554A1

    公开(公告)日:1999-07-08

    申请号:PCT/EP1998/007438

    申请日:1998-11-19

    Abstract: The invention relates to a device for producing a rapidly solidifying mixture from several liquid components and subsequently atomizing the solidifying mixture. The device comprises a mixing chamber (4), a liquid distributor (1', 7) and N equal drop-forming nozzles (9a, 9b) which are connected to the liquid distributor. The liquids to be mixed can be fed to the mixing chamber separately and the mixing chamber presents neither significant back-mixing in those areas in which reactions can occur nor significant dead spaces in the flow in these areas. The liquid distributor (1', 7) is connected to the mixing chamber and immediately distributes the mixture flow coming from the mixing chamber to the nozzles (9a, 9b) without significant back-mixing or dead spaces in said flow, so that the flow properties of the partial flows and their dwell times in the liquid distributor are the same for each such partial flow.

    Abstract translation: 本发明涉及一种用于制备几种液体成分和凝固混合物随后雾化的快速凝固的混合物的装置。 该装置包括一个混合室(4),液体分配器(1”,7)和N相等,所述液体分配器连接,落形成喷嘴(9A,9B)。 待混合的液体可以被馈送到单独的混合室和混合室具有在这些区域中的流动没有显著返混在其中的反应可发生的区域中,也不显著死空间。 液体分配器(1”,7)被连接到混合室,并从混合室混合物电流等于喷嘴分布式到来(9A,9B),而不在流动显著返混或死空间,从而使局部流的流动特性和它们的停留时间在液体分配器 是相同的。

    PERFORATED DISK OR ATOMIZING DISK AND AN INJECTION VALVE WITH A PERFORATED DISK OR ATOMIZING DISK
    129.
    发明申请
    PERFORATED DISK OR ATOMIZING DISK AND AN INJECTION VALVE WITH A PERFORATED DISK OR ATOMIZING DISK 审中-公开
    HOLE DISC OR 含孔盘式喷雾器和进样阀或 喷雾器

    公开(公告)号:WO99014487A1

    公开(公告)日:1999-03-25

    申请号:PCT/DE1998/002674

    申请日:1998-09-10

    Abstract: The invention relates to a perforated disk characterized in that a complete passage for fluid is constructed. Said passage comprises an inlet opening (40), outlet openings (42) and at least one channel (cavity) (41) situated between the inlet and outlet openings. At least three functional surfaces (45, 46, 47) of the perforated disk (23) with one respective characteristic opening structure (40, 41, 42, 43) are constructed on top of one another by means of galvanic metal precipitation (multi-layer galvanization) so that the perforated disk (23) is available in one piece. In the lower functional surface (45), gas delivery openings (43) are configured through which gas can be delivered in the direction of the fluid which is to be injected, so that the fluid can be finely sprayed. Said outlet openings (42) are part of the gas delivery openings (43). The perforated disk (23) is especially suitable for the use in injection valves for mixture compressed, externally supplied ignition internal combustion engines.

    Abstract translation: 本发明的多孔盘的特征在于,提供了一种用于流体的完整通道从一个入口开口(40),出口开口(42),并且由至少一个中间通道(空腔)(41)延伸。 多孔盘(23)的至少三个官能平面(45,46,47),每个具有特性开口结构(40,41,42,43)通过电沉积到彼此(多层电镀)建立起来的,从而使穿孔的盘(23)存在于单件。 在较低的功能平面(45)被引入气体供给开口,通过该流体被喷射的方向上的气体被供给,使得流体的非常精细的雾化是可能的(43)。 出口开口(42)是气体供给开口(43)的一部分。 多孔盘(23)是特别适合于在喷射阀使用了混合物式火花点火内燃机。

    LIQUID SPRAYING ARRANGEMENT, IN PARTICULAR HEATING OIL BURNER
    130.
    发明申请
    LIQUID SPRAYING ARRANGEMENT, IN PARTICULAR HEATING OIL BURNER 审中-公开
    雾化液体,特别是燃油型燃烧器

    公开(公告)号:WO1995005560A1

    公开(公告)日:1995-02-23

    申请号:PCT/EP1994002622

    申请日:1994-08-08

    CPC classification number: F23D11/106 B05B1/265 B05B7/0807 B05B7/0892

    Abstract: A spraying arrangement has a nozzle (1), a spraying gas supply means (11) and a liquid supply means (13) to the nozzle (1) in which the spraying gas and the liquid may be mixed before leaving the nozzle. In addition, a body (3) is centrally arranged in the axis of the nozzle (1), narrowing the cross section of the nozzle (1) in the area of the nozzle neck (15) to a ring-shaped space. The points (4) of the teeth of an element shaped as a hollow cone and having a saw-toothed end lie on the outer wall of the spreading body (3). The outer wall of the crown (2) lies on the inner wall of the nozzle neck (15), creating an inner ring-shaped space through which liquid is supplied between the spreading body (3) and the crown (2), as well as an outer ring-shaped space through which the spraying gas is supplied between the spreading body (3) and the inner wall of the nozzle (1). This low-priced, technically simple modification allows the liquid and spraying gas to be intensively mixed even at a low spraying gas pressure. A quasi-stoichiometric combustion with a reduced nitrogen oxide emission is achieved without causing the flames to touch the walls of the furnace.

    Abstract translation: 雾化器包括一个喷嘴(1),一种用于雾化气体的进料器(11),和用于将液体在喷嘴(1),其中,所述雾化气体和液体都是离开喷嘴之前混溶的入口(13)。 此外,喷嘴(1)的位于中心的轴线布置在(3)在喷嘴颈部的区域中的喷嘴(1)的横截面(15)被设置在主体变窄到一个环形空间。 具有抗膨胀体(3)的外壁上的锯齿形端部承受一个空心圆锥状部件的齿顶(4)。 冠(2)的外壁抵靠喷嘴颈部(15)的内壁上,从而使内,提供了一种用于供给膨胀体(3)和(2)形成在冠部和外之间的液体环,用于供应雾化气体 形成在膨胀体(3)和喷嘴(1)的内壁之间提供环形空间。 廉价的,廉价的修改允许液体和雾化气体的强烈混合,即使在低的雾化气体的压力。 具有降低的氮氧化物排放量与炉壁上没有火焰冲击甲近化学计量燃烧得以实现。

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