公开(公告)号：WO2011044589A2

公开(公告)日：2011-04-14

申请号：PCT/US2010052389

申请日：2010-10-12

Applicant: UNIV TEXAS ,  KRAFT EDWARD R ,  KULP GABRIELA A ,  GODLEY BERNARD F ,  KOUTROUVELIS ARISTIDES P

Inventor： KRAFT EDWARD R ,  KULP GABRIELA A ,  GODLEY BERNARD F ,  KOUTROUVELIS ARISTIDES P

IPC: A61K41/00

CPC classification number: A61K41/0057 ,  A61F9/0017 ,  A61F9/0079 ,  A61K9/0048 ,  A61K31/167 ,  A61K31/519 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7042 ,  A61K31/728 ,  A61K38/12 ,  A61K38/14 ,  A61K38/28 ,  A61K38/30 ,  A61K41/00 ,  A61K45/06 ,  A61K47/16 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0651 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662

Abstract: The present invention relates generally to transscleral and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral or transocular delivery of high molecular weight biologically active substances to a patient using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes of the eye of a subject using those compositions and methods.

Abstract translation: 本发明一般涉及生物活性物质通过患者眼睛的组织，血管和细胞膜的经巩膜和透过递送，而不会损伤细胞表面，组织或膜。 本发明提供了使用脉冲非相干光增强经巩膜和透视递送生物活性物质的组合物和方法，特别是使用脉冲非相干光的患者使用高分子量生物活性物质的超声或远视递送。 本发明还提供了一种用于使用这些组合物和方法将脉冲非相干光应用于对象的眼睛的细胞表面和膜的装置。

公开(公告)号：WO2011044589A3

公开(公告)日：2011-04-14

申请号：PCT/US2010/052389

申请日：2010-10-12

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KRAFT, Edward, R. ,  KULP, Gabriela, A. ,  GODLEY, Bernard, F. ,  KOUTROUVELIS, Aristides, P.

Inventor： KRAFT, Edward, R. ,  KULP, Gabriela, A. ,  GODLEY, Bernard, F. ,  KOUTROUVELIS, Aristides, P.

IPC: A61K41/00 ,  A61M37/00 ,  A61F9/00 ,  A61N5/06

Abstract: The present invention relates generally to transscleral and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral or transocular delivery of high molecular weight biologically active substances to a patient using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes of the eye of a subject using those compositions and methods.

公开(公告)号：WO2008094219A3

公开(公告)日：2008-08-07

申请号：PCT/US2007/020072

申请日：2007-09-15

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KRAFT, Edward, R. ,  ENKHBAATAR, Perenlei ,  TRABER, Daniel, L. ,  KULP, Gabriela, A.

Inventor： KRAFT, Edward, R. ,  ENKHBAATAR, Perenlei ,  TRABER, Daniel, L. ,  KULP, Gabriela, A.

IPC: A61M11/06 ,  A61M15/00 ,  B05B7/06

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. A nebulizationg system comprises a nozzles (10), an inner microchannel delivery tube (14) having a central fluid channel (18), and an outer gas delivery tube (12) confirgured concentrically arround the inner delivery tube.

公开(公告)号：WO2008094219A2

公开(公告)日：2008-08-07

申请号：PCT/US2007020072

申请日：2007-09-15

Applicant: UNIV TEXAS ,  KRAFT EDWARD R ,  ENKHBAATAR PERENLEI ,  TRABER DANIEL L ,  KULP GABRIELA A

Inventor： KRAFT EDWARD R ,  ENKHBAATAR PERENLEI ,  TRABER DANIEL L ,  KULP GABRIELA A

IPC: A61M11/02 ,  A61M11/06 ,  A61M15/00 ,  B05B7/06

CPC classification number: A61M15/002 ,  A61M11/04 ,  A61M11/06 ,  A61M15/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M16/06 ,  A61M2202/0007 ,  B05B7/066 ,  B05B7/0876 ,  B05B7/0892

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damages or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

Abstract translation: 描述了液体雾化器装置，系统和制剂组合物，以及用于雾化，气溶胶递送这种组合物的系统，用于将药物气溶胶施用和吹入哺乳动物的肺部系统。 雾化装置和系统可以有效地雾化药液载体的各种粘度，包括由油，水或油和水的乳液组成的药物载体。 溶解或悬浮在本文所述和适用的组合物和制剂中的药物在使用所述雾化器时不会被雾化过程所损害或变性。 此外，雾化系统本身可以适用于机械辅助肺通气系统以及用于肺部药物递送的手持式吸入器和鼻/口罩。