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    Biological information imaging apparatus
    122.
    发明专利
    Biological information imaging apparatus 有权
    生物信息成像装置

    公开(公告)号：JP2010088873A

    公开(公告)日：2010-04-22

    申请号：JP2009208506

    申请日：2009-09-09

    Applicant: Canon Inc ,  キヤノン株式会社

    Inventor： NAKAJIMA TAKAO ,  FUKUTANI KAZUHIKO

    IPC: A61B8/00

    CPC classification number: G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/02007 ,  G01N2201/0662

    Abstract: PROBLEM TO BE SOLVED: To provide a biological information imaging apparatus capable of more accurately acquiring the distribution of an absorption coefficient (μa) inside a subject (living body) by obtaining an average effective attenuation coefficient (μeff) in the living body in advance.
    SOLUTION: The biological information imaging apparatus includes: an acoustic wave detector 107 that detects an acoustic wave generated from a light absorber 105 which has absorbed a part of the energy of light emitted from a light source 103 to the subject 100, and converts it to a first electrical signal; a photodetector 110 that converts intensities corresponding to a plurality of propagation distances of the light emitted from the light source 109 and propagated through the subject 100 to a second electrical signal; a signal processing apparatus 111 that derives the average effective attenuation coefficient (μeff) of the subject 100 based on the second electrical signal and derives the distribution of the absorption coefficient (μa) of the subject 100 based on the first electrical signal and the average effective attenuation coefficient (μeff); and an image constructing apparatus 111 that forms an image of the distribution of the absorption coefficient (μa) based on the distribution of the absorption coefficient (μa) derived by the signal processing apparatus 111.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 解决问题：提供一种能够通过获得生物体内的平均有效衰减系数（μeff）更准确地获取被检体（活体）内的吸收系数（μa）的分布的生物信息摄像装置 提前。 解决方案：生物信息成像装置包括：声波检测器107，其检测从吸收了从光源103发射到被摄体100的光的一部分能量的光吸收体105产生的声波;以及 将其转换为第一电信号; 光电检测器110，其将对应于从光源109发射的光的多个传播距离对应的强度转换为第二电信号; 信号处理装置111，其基于第二电信号导出被检体100的平均有效衰减系数（μeff），并且基于第一电信号和平均有效值导出被检体100的吸收系数（μa）的分布 衰减系数（μeff）; 以及基于由信号处理装置111导出的吸收系数（μa）的分布形成吸收系数（μa）的分布的图像的图像构成装置111.（C）2010，JPO＆INPIT

    Method and system for noninvasive measurement of blood component concentration
    123.
    发明专利
    Method and system for noninvasive measurement of blood component concentration 审中-公开
    血液成分浓度非线性测量方法与系统

    公开(公告)号：JP2004283585A

    公开(公告)日：2004-10-14

    申请号：JP2004079140

    申请日：2004-03-18

    Applicant: Samsung Electronics Co Ltd ,  三星電子株式会社

    Inventor： JEON KYE-JIN ,  YOON GIL-WON ,  HWANG IN-DUK ,  HAN SANG-JOON

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/107 ,  A61B5/1455

    CPC classification number: A61B5/14532 ,  A61B5/0053 ,  A61B5/107 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/359 ,  G01N2021/036 ,  G01N2021/3144 ,  G01N2201/0662

    Abstract: PROBLEM TO BE SOLVED: To provide a method for noninvasive measurement of blood component concentration by adjusting thickness of specific soft tissue by a subject to be measured to vary volumes of blood and interstitial fluid and using differential absorption spectrums corresponding to a change amount of the fluids. SOLUTION: This method comprises (a) a process of varying thickness of a specific position of a subject to be measured to use a first differential absorption spectrum of the absorption spectrum measured at each of the varied thickness and the concentration of the measured specific blood component to establish a statistical model and (b) a process of predicting the blood component from a second differential absorption spectrum measured at a specific position of the subject based on the statistical model. Thereby, the influence of extracellular fluid is increased to remove obstructing or interfering factors against the specific blood component measurement and to obtain more accurate prediction of concentration of the blood component. COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种通过调整被测定对象的特定软组织的厚度来改变血液和间质液的体积并使用对应于变化量的差异吸收光谱来无血压测量血液成分浓度的方法 的流体。 解决方案：该方法包括（a）使被测定对象的特定位置的厚度变化，以使用在每个变化的厚度下测量的吸收光谱的第一差分吸收光谱和所测量的浓度 以建立统计模型，以及（b）基于统计模型从在对象的特定位置测量的第二差分吸收光谱预测血液成分的过程。 因此，增加细胞外液的影响，以消除针对特定血液成分测量的阻碍或干扰因素，并获得对血液成分浓度的更准确的预测。 版权所有（C）2005，JPO＆NCIPI

    IMAGE ACQUISITION DEVICE, IMAGE FORMATION SYSTEM, AND IMAGE FORMATION METHOD
    125.
    发明公开
    IMAGE ACQUISITION DEVICE, IMAGE FORMATION SYSTEM, AND IMAGE FORMATION METHOD 审中-公开
    图像获取设备，图像形成系统和图像形成方法

    公开(公告)号：EP3225975A1

    公开(公告)日：2017-10-04

    申请号：EP15864158.9

    申请日：2015-11-05

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： SATO, Taichi ,  SAWADA, Yoshihide ,  ADACHI, Yasuhiko ,  MOTOMURA, Hideto

    IPC: G01N21/27 ,  G02B21/34 ,  H04N5/232

    CPC classification number: G02B21/365 ,  G01N21/49 ,  G01N21/59 ,  G01N2201/0662 ,  G02B21/0008 ,  G02B21/06 ,  G02B21/086 ,  G02B21/26 ,  H04N5/2256 ,  H04N5/23232 ,  H04N5/2354 ,  H04N5/2356

    Abstract: An image acquisition device according to the present disclosure includes a lighting system and an irradiation direction decision section. In a module, a subject and an imaging element are integrally formed. The lighting system sequentially irradiates the subject with illumination light in a plurality of different irradiation directions based on the subject such that the illumination light transmitted through the subject is incident on the imaging element. The module acquires a plurality of images according to the plurality of different irradiation directions. Before the plurality of images are acquired according to the plurality of different irradiation directions, the irradiation direction decision section decides the plurality of different irradiation directions based on a difference between a first preliminary image and a second preliminary image. The first preliminary image is acquired when the subject is irradiated with first illumination light in a first irradiation direction, and the second preliminary image is acquired when the subject is irradiated with second illumination light in a second irradiation direction.

    Abstract translation: 根据本公开的图像获取装置包括照明系统和照射方向判定部分。 在模块中，主体和成像元件一体地形成。 照明系统以基于被摄体的多个不同照射方向的照明光依次照射被摄体，使得透过被摄体的照明光入射到摄像元件上。 模块根据多个不同的照射方向获取多个图像。 在根据多个不同的照射方向获取多个图像之前，照射方向判定部分基于第一预备图像和第二预备图像之间的差异来判定多个不同的照射方向。 当在第一照射方向上用第一照明光照射对象时获取第一预备图像，并且当在第二照射方向上用第二照明光照射对象时获取第二预备图像。

    INFRARED SENSOR WITH MUTIPLE SOURCES FOR GAS MEASUREMENT
    126.
    发明公开
    INFRARED SENSOR WITH MUTIPLE SOURCES FOR GAS MEASUREMENT 审中-公开
    红细胞生成素麻醉师梅尔

    公开(公告)号：EP2758766A1

    公开(公告)日：2014-07-30

    申请号：EP12775873.8

    申请日：2012-09-12

    Applicant: MSA Technology, LLC

    Inventor： STARTA, Christopher, D. ,  UBER, Robert, E. ,  TRAUTZSCH, Thomas ,  SCHULER, Frederick, J.

    IPC: G01N21/35 ,  G01N21/31

    CPC classification number: G01N21/59 ,  G01N21/3151 ,  G01N21/3504 ,  G01N2201/023 ,  G01N2201/0636 ,  G01N2201/0662

    Abstract: A closed path infrared sensor includes an enclosure, a first energy source within the enclosure, at least a second energy source within the enclosure, at least one detector system within the enclosure and a mirror system external to the enclosure and spaced from the enclosure. The mirror system reflects energy from the first energy source to the at least one detector system via a first analytical path and reflects energy from the second energy source to the at least one detector system via a second analytical path. Each of the first analytical path and the second analytical path are less than two feet in length.

    Abstract translation: 封闭路径红外传感器包括外壳，外壳内的第一能量源，外壳内的至少第二能量源，外壳内的至少一个检测器系统和外壳外部并与外壳隔开的反射镜系统。 反射镜系统经由第一分析路径将来自第一能量源的能量反射到至少一个检测器系统，并且经由第二分析路径将来自第二能量源的能量反射到至少一个检测器系统。 第一分析路径和第二分析路径中的每一条长度小于两英尺。

    SPECTROPHOTOMETER
    129.
    发明公开
    SPECTROPHOTOMETER 审中-公开
    分光光度计

    公开(公告)号：EP1880193A1

    公开(公告)日：2008-01-23

    申请号：EP05816550.7

    申请日：2005-12-01

    Applicant: FOSS Analytical A/S

    Inventor： JUHL, Henrik, Vilstrup

    IPC: G01N21/03 ,  G01N21/31

    CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

    Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

    Abstract translation: 一种分光光度计（2），其包括放射源（6），优选为光辐射，其被设置为朝向样本架（4）中的样本以多个波长发射辐射，以及检测装置8，用于在辐射与 例子。 样本保持器（4）适于为通过样本的发射的辐射呈现多个不同的路径长度。 运算单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出并且适于将检测到的发射辐射的强度值存储在其多个路径长度中 并且计算依赖于在两个路径长度中的每一个处的索引强度值的比率的值，通过该比值利用分光光度计（2）指示存在感兴趣物质包括辐射源（6）， （优选为光辐射），其被设置成向多个波长发射朝向样本架（4）中的样本的辐射，以及检测装置8，用于在辐射与样本相互作用之后检测辐射。 样品架（4）进行适配以呈现出通过样品发射的辐射的多个不同路径长度。 运算单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出并且适于将检测到的发射辐射的强度值存储在其多个路径长度中 并计算取决于在两个路径长度中的每一个路径长度处的索引强度值的比率的值，通过该值可以获得在保留的样本内存在感兴趣物质的指示。

    METHOD OF PHOTOMETRIC $i(IN VITRO) DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE
    130.
    发明授权
    METHOD OF PHOTOMETRIC $i(IN VITRO) DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE 失效
    METHOD FOR光度法（体外）测定样品中分析物的含量的

    公开(公告)号：EP0605598B1

    公开(公告)日：1997-07-30

    申请号：EP92920833.8

    申请日：1992-09-17

    Applicant: RADIOMETER MEDICAL A/S

    Inventor： FRISCHAUF, Peter, Aage

    IPC: G01N21/03 ,  G01N33/48

    CPC classification number: G01N21/0303 ,  G01N21/314 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2035/1062 ,  G01N2201/0662

    Abstract: The present method is a method of photometric in vitro determination of the content of an analyte in a sample. The sample is located in a measuring chamber device with a measuring chamber, which has a defined radiation path length and has at least one at least partially transparent wall part. The measuring chamber is in optical communication with an optical system adapted for the analyte and comprising a radiation source and a radiation detector. Further, the measuring chamber is adjustable in shape thereby controlling the setting of the radiation path length across the measuring chamber. In a first measuring step a first radiation path length across the measuring chamber is set and radiation at at least one wavelength is transmitted from the radiation source through the measuring chamber and to the radiation detector. Then in a second step the measuring chamber is adjusted in shape thereby setting a second wavelength across the measuring chamber. Radiation at the same wavelength as during the first step is again transmitted from the radiation source through the measuring chamber and to the radiation detector. The analyte content is then determined on the basis of radiation detected in each of the measuring steps.

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