公开(公告)号：WO2004040284A1

公开(公告)日：2004-05-13

申请号：PCT/DK2003/000728

申请日：2003-10-29

Applicant: RADIOMETER MEDICAL A/S

Inventor： FRISCHAUF, Peter, Aage ,  LARSEN, Eiler

IPC: G01N27/00

CPC classification number: G01N33/4915

Abstract: The present invention provides a method of performing calibration and quality control of a sensor for determining a parameter in a test fluid in which method a calibration and quality control cycle is repeated. A cycle comprises the steps of performing a calibration and a quality control of the sensor using independent reference materials. In the method a reference material is in one cycle used in the quality control step which in another cycle is used in the calibration step. The present invention further provides an apparatus for performing said method.

Abstract translation: 本发明提供一种执行用于确定测试流体中的参数的传感器的校准和质量控制的方法，其中重复校准和质量控制循环。 循环包括以下步骤：使用独立参考材料执行传感器的校准和质量控制。 在该方法中，在质量控制步骤中使用一个循环中的参考材料，其在另一个循环中用于校准步骤。 本发明还提供一种用于执行所述方法的装置。

公开(公告)号：WO1995000473A1

公开(公告)日：1995-01-05

申请号：PCT/DK1994000254

申请日：1994-06-22

Applicant: RADIOMETER MEDICAL A/S ,  BYRNARD, Allan, Milton ,  UNGARO, Rocco ,  POCHINI, Andrea

Inventor： RADIOMETER MEDICAL A/S

IPC: C07C245/08

CPC classification number: C07C245/10 ,  G01N33/84

Abstract: A novel calix[4]arene compound, application of the compounds as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The calix[4]arene compound has general formula (I). The sensor is not very sensitive to sodium and potassium ions.

Abstract translation: 新型的杯[4]芳烃化合物，化合物作为活性成分在钙敏感传感器中的应用，以及含有该化合物的钙敏感传感器。 杯[4]芳烃化合物具有通式（I）。 传感器对钠和钾离子不太敏感。

公开(公告)号：WO1994018559A1

公开(公告)日：1994-08-18

申请号：PCT/DK1994000058

申请日：1994-02-09

Applicant: RADIOMETER MEDICAL A/S

Inventor： RADIOMETER MEDICAL A/S ,  WILLIS, John, P. ,  PIVATO, Rayvenne, L.

IPC: G01N33/52

CPC classification number: G01N33/521

Abstract: The invention relates to an asymmetric membrane having a chromogen indicator coating located downstream of and adjacent to the downstream (smaller porosity) side of the asymmetric membrane. Bleed-through is not a problem and precise measurement of various blood parameters is thereby achieved. The sensor may be used for measurement of a variety of analytes, including glucose, lactate, creatinine, urea (BUN), uric acid, pyruvic acid, ascorbic acid and cholesterol. Additionally, the invention relates to disposable cassettes employing the sensor and analytical systems employing same. The invention further relates to techniques for constructing and operating the sensor.

Abstract translation: 本发明涉及一种不对称膜，其具有位于不对称膜的下游（较小孔隙率）的下游并与其相邻的色原指示剂涂层。 渗透不是问题，从而实现各种血液参数的精确测量。 传感器可用于测量各种分析物，包括葡萄糖，乳酸，肌酸酐，尿素（BUN），尿酸，丙酮酸，抗坏血酸和胆固醇。 此外，本发明涉及使用传感器的一次性盒和使用其的分析系统。 本发明还涉及构造和操作传感器的技术。

公开(公告)号：WO1997046887A1

公开(公告)日：1997-12-11

申请号：PCT/DK1997000238

申请日：1997-05-27

Applicant: RADIOMETER MEDICAL A/S ,  LUNDSGAARD, Finn, Chresten ,  KAGENOW, Henrik ,  ANDERSEN, Willy ,  FRISCHAUF, Peter, Aage

Inventor： RADIOMETER MEDICAL A/S

IPC: G01N35/00

CPC classification number: G01N35/025 ,  G01N33/4925 ,  G01N2035/00277 ,  G01N2035/00752 ,  G01N2035/041 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/25

Abstract: The method comprises arranging a plurality of test devices in a holder, and loading, to at least one of the test devices, a sample of a physiological liquid. The at least one parameter of the sample loaded to the at least one test device is then determined, the at least one test device being retained in the holder after the determination. The holder with the at least one test device retained therein is then discarded in such a manner that the at least one test device is substantially separated from the ambience, thus reducing the risk of contact between an operator and sample loaded to the at least one test device.

Abstract translation: 该方法包括在保持器中布置多个测试装置，并将至少一个测试装置装载到生理液体的样品。 然后确定加载到至少一个测试装置的样品的至少一个参数，所述至少一个测试装置在确定之后保留在保持器中。 然后将保持有至少一个测试装置的支架以这样的方式被丢弃，使得至少一个测试装置与环境基本上分离，从而降低操作者与加载到至少一个测试中的样品之间的接触风险 设备。

公开(公告)号：US20030236497A1

公开(公告)日：2003-12-25

申请号：US10465894

申请日：2003-06-20

Applicant: Radiometer Medical A/S

Inventor： Niels Fremming ,  Jorgen Andersen

IPC: A61M001/00

CPC classification number: B01L3/502 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150732 ,  A61B5/154 ,  A61J1/145 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2065 ,  A61J1/2075 ,  A61J1/2086 ,  A61J1/2096 ,  B01L2200/026 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N35/1079

Abstract: A sampler cap includes a sampler connector, an analyzer connector and a liquid impermeable closure member, which may be a membrane or a filter. The sampler cap may be used to transfer a test sample to an analyzer without removing the sampler cap from the sampler.

Abstract translation: 采样器盖包括采样器连接器，分析器连接器和液体不可渗透的封闭构件，其可以是膜或过滤器。 采样器盖可用于将测试样品转移到分析仪，而不从采样器中取出采样器盖。

公开(公告)号：WO1997008561A1

公开(公告)日：1997-03-06

申请号：PCT/DK1996000362

申请日：1996-08-29

Applicant: RADIOMETER MEDICAL A/S ,  SPORK, Allan ,  PEDERSEN, Bent ,  FREMMING, Niels ,  HVIDTFELDT, Kristian, Jacob

Inventor： RADIOMETER MEDICAL A/S

IPC: G01N35/00

CPC classification number: G01N33/4925 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The apparatus is for example an apparatus for blood gas analysis and has equipment for automatic introduction of reference fluid for the apparatus, comprising a holder (81) for concurrent hold of several ampoules (10) with reference fluid, for bringing a selected container into a specific position in relation to means (28) for opening the container, for bringing the opened container into a specific position in relation to an inlet aggregate for introduction of fluid from the container into the apparatus, and after activation of the inlet aggregate, for removing the container and the inlet aggregate from each other. The ampoule (10) is opened by pressing down a cap. Another ampoule (10) has a planar membrane comprising one or several glass layers.

Abstract translation: 该设备例如是用于血液气体分析的装置，并且具有用于自动引入用于该设备的参考流体的设备，包括用于同时保持具有参考流体的几个安瓿（10）的保持器（81），用于将选定的容器 相对于用于打开容器的装置（28）的特定位置，用于将打开的容器相对于入口聚集体进入到特定位置，用于将流体从容器引入装置中，以及在活化入口聚集体之后， 容器和入口聚集在一起。 通过按压帽打开安瓿（10）。 另一个安瓿（10）具有包括一个或多个玻璃层的平面膜。

公开(公告)号：WO1995004266A1

公开(公告)日：1995-02-09

申请号：PCT/DK1994000297

申请日：1994-08-01

Applicant: RADIOMETER MEDICAL A/S ,  FODGAARD, Henrik ,  SINGER, Rolf ,  FABRICIUS, Paul, Erik

Inventor： RADIOMETER MEDICAL A/S

IPC: G01N21/35

CPC classification number: G01N21/359 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61M1/14 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/367 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/50 ,  G01J3/2803 ,  G01N2021/058 ,  G01N2201/129

Abstract: A method and an apparatus for determining the content of a constituent of blood of an individual are disclosed. In the method a whole blood stream is extracted from a blood vessel of said individual, the stream being directed through a path defining a substantially non-varying flow-through area wherein is provided a flow-through measuring cuvette including opposite first and second optical transparent surface parts defining an optical transmission path of the order of 0.5 - 2.0 mm. The whole blood stream flowing through the measuring cuvette is irradiated by irradiating the first optical transparent surface part of the measuring cuvette with multi-wavelength near infrared light. The near infrared absorption spectrum is detected and the content of the constituent is quantified on the basis of the detected near infrared absorption data. The method is particularly suited for measuring constituents of whole blood in an extracorporeal loop, for example in hemodialysis.

Abstract translation: 公开了一种用于确定个体血液成分含量的方法和装置。 在该方法中，从所述个体的血管中提取全血流，所述流被引导通过限定基本上不变的流通区域的路径，其中设置有包括相对的第一和第二光学透明的流过测量比色皿 表面部件限定0.5-2.0mm的光传输路径。 通过用多波长近红外光照射测量反应杯的第一光学透明表面部分来照射流过测量反应杯的全部血液。 检测近红外吸收光谱，并根据检测到的近红外吸收数据量化成分的含量。 该方法特别适用于测量体外循环中全血的成分，例如在血液透析中。

公开(公告)号：WO2004057304A1

公开(公告)日：2004-07-08

申请号：PCT/DK2002/000892

申请日：2002-12-20

Applicant: RADIOMETER MEDICAL A/S

Inventor： HVIDTFELDT, Kristian, Jacob ,  AAS, Flemming ,  FREDERIKSEN, Caspar, Buchholtz ,  HANSEN, Erik, Kjoelbye

IPC: G01N1/16

CPC classification number: G01N35/0098 ,  B01F13/0818 ,  B01F2215/0037

Abstract: A blood analyzer has a control system controlling the operation of the analyzer, a sensor measuring a parameter of a blood sample, exposure means exposing the sensor to the blood sample, reporting means reporting the parameter of the blood sample, and a sample handler. The sample handler comprises a sampler bed receiving a blood sampler which contains the blood sample and a stirring element. The sample handler further comprises moving means moving the stirring element in the blood sampler when the sampler is arranged in the sampler bed. The blood analyzer is capable of handling and analyzing blood samples. A blood sample handler is provided as well, as are methods for handling and analyzing of a blood sample. The moving means moving the stirring element is preferably a magnet and the stirring element is magnetic.

Abstract translation: 血液分析仪具有控制分析器的操作的控制系统，测量血液样本参数的传感器，将传感器暴露于血液样本的曝光装置，报告血样的参数的报告单元和样品处理器。 样品处理器包括接收血液取样器的采样器床，其包含血液样品和搅拌元件。 样品处理器还包括当采样器布置在采样器床中时移动血液采样器中的搅拌元件的移动装置。 血液分析仪能够处理和分析血液样本。 还提供血液样品处理器，以及用于处理和分析血液样品的方法。 移动搅拌元件的移动装置优选地是磁体，并且搅拌元件是磁性的。

公开(公告)号：WO2004000412A1

公开(公告)日：2003-12-31

申请号：PCT/DK2003/000414

申请日：2003-06-20

Applicant: RADIOMETER MEDICAL A/S

Inventor： FREMMING, Niels ,  ANDERSEN, Jørgen

IPC: A61M39/20

CPC classification number: B01L3/502 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150732 ,  A61B5/154 ,  A61J1/145 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2065 ,  A61J1/2075 ,  A61J1/2086 ,  A61J1/2096 ,  B01L2200/026 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N35/1079

Abstract: A sampler cap includes a sampler connector, an analyzer connector and a liquid impermeable closure member, which may be a membrane or a filter. The sampler cap may be used to transfer a test sample to an analyzer without removing the sampler cap from the sampler.

Abstract translation: 采样器盖包括采样器连接器，分析器连接器和液体不可渗透的封闭构件，其可以是膜或过滤器。 采样器盖可用于将测试样品转移到分析仪，而不从采样器中取出采样器盖。

公开(公告)号：WO1998021356A1

公开(公告)日：1998-05-22

申请号：PCT/DK1997000508

申请日：1997-11-07

Applicant: RADIOMETER MEDICAL A/S ,  AHL, Thomas ,  BYRNARD, Allan, Milton

Inventor： RADIOMETER MEDICAL A/S

IPC: C12Q01/00

CPC classification number: C12Q1/002 ,  C12N11/02 ,  C12Q1/005 ,  Y10S435/963 ,  Y10S435/973

Abstract: The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte of a test fluid. The sensor has at least one enzyme layer comprising an immobilised enzyme for which the analyte is a substrate. The immobilised enzyme is obtained by formation of one or more covalent link(s), optionally by using a cross-linking agent, between the enzyme and at least one type of macromolecule in the presence of a competitive inhibitor for said enzyme. The present invention also relates to a membrane for an enzyme sensor. Furthermore, the invention relates to a method for stabilising the enzymatic activity of an enzyme sensor.

Abstract translation: 本发明涉及一种用于测量被测流体分析物的浓度或活性的酶传感器。 该传感器具有至少一个酶层，其包含固定化酶，分析物为基质。 通过在所述酶的竞争性抑制剂存在下，在所述酶和至少一种类型的大分子之间形成一种或多种共价连接，任选地通过使用交联剂获得所述固定化酶。 本发明还涉及一种酶传感器的膜。 此外，本发明涉及稳定酶传感器酶活性的方法。