公开(公告)号：US07057973B2

公开(公告)日：2006-06-06

申请号：US11185544

申请日：2005-07-19

Applicant: Gary W. Ferrell

Inventor： Gary W. Ferrell

IPC: G01N21/02

CPC classification number: G01N21/8507 ,  G01N21/1702 ,  G01N21/70 ,  G01N2021/8411 ,  G01N2201/0833 ,  H01L21/67028

Abstract: A method, probe, and system for detecting presence of cavitation in a fluid and measuring cavitation density and intensity of a specific locale in the fluid. A first cavitation void and associated energy perturbation, produced in a first fluid, moves within the first fluid and is received at a very thin plate, which separates the first fluid from a second fluid and is part of a light-proof chamber containing the second fluid. An energy perturbation in the first fluid is received at the thin plate and produces at least one cavitation void or associated energy perturbation in the second fluid; and the energy perturbation in the second fluid is eventually converted into an electromagnetic signal. This signal is received by a photomultiplier and converted to an electronic signal that indicates the presence of cavitation. The system can distinguish between cavitation voids produced at one location and/or time interval and voids produced at another location and/or another time interval.

Abstract translation: 一种用于检测流体中气穴的存在并测量流体中特定区域的空化密度和强度的方法，探针和系统。 在第一流体中产生的第一空化空穴和相关的能量扰动在第一流体内移动并且被接收在非常薄的板上，该薄板将第一流体与第二流体分离，并且是含有第二流体的防光室的一部分 流体。 在薄板处接收第一流体中的能量扰动，并在第二流体中产生至少一个空化空穴或相关联的能量扰动; 并且第二流体中的能量扰动最终被转换成电磁信号。 该信号被光电倍增管接收并转换成指示气蚀存在的电子信号。 该系统可以区分在一个位置产生的空化空穴和/或时间间隔以及在另一个位置和/或另一个时间间隔产生的空隙。

公开(公告)号：US07057726B2

公开(公告)日：2006-06-06

申请号：US11130848

申请日：2005-05-17

Applicant: Claire Elizabeth Hooper, legal representative

Inventor： John Gordon Rushbrooke, deceased

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fiber optic epi-fluorescence imaging system in which the optical fibers are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibers (32, 46) or bundles of fibers which lead to a CCD camera (74), the fibers or bundles of fibers from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibers formed therefrom to have a higher numerical aperature than those of the first set.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。 该系统包括通向CCD照相机（74）的至少两根光纤（32,46）或纤维束，来自所有样品的纤维或纤维束被布置成两组，第一组由 非荧光材料和第二组，其由可以发荧光但使得由其形成的纤维具有比第一组更高的数值的材料形成。

公开(公告)号：US20050213099A1

公开(公告)日：2005-09-29

申请号：US11130848

申请日：2005-05-17

Applicant: John Rushbrooke ,  Claire Hooper

Inventor： John Rushbrooke ,  Claire Hooper

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic epi-fluorescence imaging system in which the optical fibres are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibres (32, 46) or bundles of fibres which lead to a CCD camera (74), the fibres or bundles of fibres from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibres formed therefrom to have a higher numerical aperature than those of the first set.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。 该系统包括通向CCD照相机（74）的至少两根光纤（32,46）或纤维束，来自所有样品的纤维或纤维束被布置成两组，第一组由 非荧光材料和第二组，其由可以发荧光但使得由其形成的纤维具有比第一组更高的数值的材料形成。

公开(公告)号：US20040010397A1

公开(公告)日：2004-01-15

申请号：US10408511

申请日：2003-04-07

Inventor： Randall L. Barbour ,  Yaling Pei

IPC: G06F015/00

CPC classification number: G06T11/006 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/1787 ,  G01N2021/475 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Computation-saving techniques and stability-adding techniques provide for fast, accurate reconstructions of a time series of images involving large-scale 3D problems, such as real-time image recovery in an optical tomography imaging system. A system equation for a target medium (116) such as tissue is solved using a Normalized Difference Method (NDM) (250). Because of the inherent stability of the NDM solutions, a weight matrix (W) of the system equation can be provided for a given point in a time series (220), then reused without recalculation at subsequent points. Further savings are achieved by decomposing W using singular value decomposition or direct matrix decomposition, transforming it to reduce its dimensions, and/or scaling it to achieve a more stable numerical solution. Values of measured energy (112) emerging from the target medium are back-substituted into the system equation for the different points to obtain the target medium properties.

Abstract translation: 计算节省技术和稳定性增加技术提供了涉及大规模3D问题的时间序列图像的快速，精确重建，例如光学层析成像系统中的实时图像恢复。 使用归一化差分法（NDM）（250）解决诸如组织的目标介质（116）的系统方程式。 由于NDM解决方案的固有稳定性，可以为时间序列（220）中的给定点提供系统方程的权重矩阵（W），然后在后续点重新计算。 通过使用奇异值分解或直接矩阵分解来分解W来实现进一步的节省，将其变换以减小其尺寸，和/或缩放以实现更稳定的数值解。 从目标介质出现的测量能量（112）的值被替代为不同点的系统方程，以获得目标介质特性。

公开(公告)号：US06563584B1

公开(公告)日：2003-05-13

申请号：US09743681

申请日：2001-03-15

Applicant: Noriko Yurino ,  Kenji Yamamoto ,  Kentaro Shishido

Inventor： Noriko Yurino ,  Kenji Yamamoto ,  Kentaro Shishido

IPC: G01N2125

CPC classification number: G01N21/6452 ,  B01J2219/00536 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/06 ,  G01N27/44721 ,  G01N33/487 ,  G01N33/582 ,  G01N35/00069 ,  G01N2201/0833

Abstract: The invention uses a continuous-wave laser as an excitation light source to achieve highly-accurate detection with a simple structure. A sample 11a is irradiated with excitation light from an excitation light source 30, and then transported to an optical axis of a fluorescence detector 50, thereby being detected of its fluorescence intensity.

Abstract translation: 本发明使用连续波激光器作为激发光源，以简单的结构实现高精度的检测。 用来自激发光源30的激发光照射样品11a，然后将其输送到荧光检测器50的光轴，从而检测其荧光强度。

公开(公告)号：US06417506B1

公开(公告)日：2002-07-09

申请号：US09642243

申请日：2000-08-17

Applicant: Daniel Pinkel ,  Joe Gray ,  Donna G. Albertson

Inventor： Daniel Pinkel ,  Joe Gray ,  Donna G. Albertson

IPC: C25D1300

CPC classification number: G01N21/6452 ,  B01J2219/00513 ,  B01J2219/00524 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00659 ,  C12Q1/6825 ,  G01N21/648 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2201/0833 ,  G02B6/04

Abstract: The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its “sensor end” biological “binding partners” (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors—such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.

公开(公告)号：US06111653A

公开(公告)日：2000-08-29

申请号：US37163

申请日：1998-03-10

Applicant: Stephen Paul Bucknell ,  Nigel John Peter Winsey ,  Desmond Roy Gale

Inventor： Stephen Paul Bucknell ,  Nigel John Peter Winsey ,  Desmond Roy Gale

IPC: A61B5/103 ,  G01N21/47 ,  G01B9/02

CPC classification number: G01N21/474 ,  G01N2021/4747 ,  G01N2021/4773 ,  G01N2201/062 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: The translucency of a material is determined by illuminating the material and detecting the intensity of radiation leaving the material as a function of distance from the radiation source. The resulting measurements may be used to determine a "translucency gradient" for the material. In the case of materials in sheet form or having a defined thickness, the translucency can be measured in transmission mode or back scattering mode to measure "through translucency" or "surface translucency".

Abstract translation: 通过照射材料并检测离开材料的辐射强度作为距离辐射源的距离的函数来确定材料的半透明度。 所得到的测量可以用于确定材料的“半透明度梯度”。 在片材形式或具有规定厚度的材料的情况下，可以以透射模式或背散射模式测量半透明度以测量“通过半透明”或“表面半透明”。

公开(公告)号：US5837196A

公开(公告)日：1998-11-17

申请号：US592779

申请日：1996-01-26

Applicant: Daniel Pinkel ,  Richard L. Segraves ,  Ye Yz Zhai ,  Donna G. Albertson ,  Joe Gray

Inventor： Daniel Pinkel ,  Richard L. Segraves ,  Ye Yz Zhai ,  Donna G. Albertson ,  Joe Gray

IPC: C12N15/09 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/77 ,  G01N33/53 ,  G01N33/543 ,  G01N37/00 ,  G02B6/04 ,  G01N21/00 ,  G01N15/06 ,  G01N21/29

CPC classification number: G01N21/6452 ,  C12Q1/6825 ,  G01N21/7703 ,  G02B6/04 ,  B01J2219/00605 ,  B01J2219/00659 ,  G01N2201/0833

Abstract: The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors--such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.

公开(公告)号：US5125747A

公开(公告)日：1992-06-30

申请号：US596513

申请日：1990-10-12

Applicant: Emile Sayegh ,  Eric F. Mooney

Inventor： Emile Sayegh ,  Eric F. Mooney

IPC: G01N21/27 ,  G01N21/31 ,  G01N21/53 ,  G01N21/85

CPC classification number: G01N21/85 ,  G01N21/274 ,  G01N21/314 ,  G01N21/532 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Optical analytical instruments to determine a physical parameter of a fluid, and methods of operation of such instruments, are shown. These employ a source of suitable optical radiation, a detector means, means defining a zone for the fluid, means defining an optical path from the radiation source through the fluid zone to the detector means, and reading and control circuitry. At least two readings of optical energy that has been influenced by the fluid are taken without there having occurred substantial change to the fluid. During one of the readings a filter of known absorbance is included in the optical path so that the respective reading represents a calibration reading. A calibration-value-determining means is constructed first to compare, effectively, the two readings to remove the effect of the fluid from the value of the calibration reading, second, to compare, effectively the residual value of the calibration reading to a known value based on the known absorbance of the filter, and, third, on the basis of the second comparison, to make a calibration adjustment based on values derived while the fluid sample remained unchanged in the fluid zone. Novel software implementations of the determinations are shown. Specific examples of instruments and methods implementing these features shown are a dual lamp, no-moving part in-line spectrophotometer, a no-moving part reflection colorimeter capable of on-line or off-line operation, a scatter or fluorescence detecting implementation and a turbidimeter.

公开(公告)号：US4818861A

公开(公告)日：1989-04-04

申请号：US64573

申请日：1987-06-22

Applicant: Hideyuki Horiuchi ,  Chiaki Shimbo ,  Yoichi Onodera ,  Ryuichi Suzuki

Inventor： Hideyuki Horiuchi ,  Chiaki Shimbo ,  Yoichi Onodera ,  Ryuichi Suzuki

IPC: G01N21/59 ,  H04N1/028 ,  H01J3/14

CPC classification number: H04N1/0281 ,  G01N21/5911 ,  G01N2201/0833

Abstract: In a film image reading out device, in which one surface of a film, where images are recorded, is scanned repeatedly with a laser light beam along a scanning line and images are read out by detecting continuously light, which has passed through the film, while moving the film with a low speed in the direction, which is perpendicular to the scanning line, a light diffusing member is disposed closely to the surface opposite to that of the film scanned with the laser light beam and the optical density of the film is detected continuously by leading transmitted and diffused light to a photodetector by means of a bundle of optical fibers.

Abstract translation: 在电影图像读出装置中，其中记录有图像的胶片的一个表面沿着扫描线用激光重复扫描，并且通过检测已经通过胶片的连续光来读出图像， 在与垂直于扫描线的方向上以低速移动胶片的同时，光扩散部件靠近与用激光束扫描的胶片的表面相反的表面设置，并且胶片的光密度为 通过一束光纤将发射和扩散的光引导到光电检测器来连续检测。