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    PROCESS FOR PRODUCING POLYSACCHARIDE FROM COFFEE BEAN OR/AND COFFEE EXTRACTION RESIDUE
    131.
    发明公开
    PROCESS FOR PRODUCING POLYSACCHARIDE FROM COFFEE BEAN OR/AND COFFEE EXTRACTION RESIDUE 审中-公开
    用于生产多糖从咖啡豆或/和咖啡萃取残留物

    公开(公告)号：EP1985635A1

    公开(公告)日：2008-10-29

    申请号：EP07714164.6

    申请日：2007-02-14

    Applicant: UCC Ueshima Coffee Co., Ltd. ,  Osaka Prefecture University Public Corporation

    Inventor： IWAI, Kazuya ,  KASAI, Naoya

    IPC: C08B37/00 ,  A61K36/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P19/06 ,  A61P37/08

    CPC classification number: A61K36/74 ,  C08B37/0003 ,  C08B37/006 ,  C08B37/0087 ,  C12P19/04

    Abstract: A process for efficiently producing a polysaccharide from coffee beans or/and a coffee extraction residue. Use of these has not received attention because of difficulty in decomposing these. The process, which is for producing a polysaccharide from coffee beans or/and a coffee extraction residue, comprises: a step (a) in which the coffee beans or/and coffee extraction residue are reduced to particles having a diameter of 10.0 µm to 5.0 mm; a step (b1) in which after the step (a), the particles are heated at 50-100°C in the presence of a dilute alkali; a step (c1) in which after completion of the step (b1), cellulase is caused to act thereon; a step (b2) in which after the step (c1), a heat treatment is conducted at 120°C or higher in the presence of a dilute alkali; and a step (c2) in which after the step (b2), cellulase is caused to act thereon.

    Abstract translation: 一种用于有效地制造从咖啡豆和/或咖啡提取残渣的多糖处理。 合成的使用还没有收到由于分解合成困难的关注。 这个过程中，所有这些是用于从咖啡豆和/或咖啡提取残渣的多糖，包括：一个步骤（a），其中所述咖啡豆和/或咖啡提取残渣减少到颗粒直径为10.0微米到5.0 毫米; 步骤后的工序（b1），其中（a）中，颗粒在50-100℃下，在稀碱的存在下加热; 在步骤（b1）的完成之后，其中，步骤（c1），纤维素酶被导致在其上的作用; 在步骤（c1）之后，其中，步骤（b2）中，热处理是在120℃或更高的稀碱的存在下进行; 和步骤（b2）之后，其中，步骤（c2）中，纤维素酶被导致在其上的作用。

    MONOCLONAL ANTIBODY DIRECTED AGAINST CD166 AND METHOD FOR PRODUCTION THEREOF
    132.
    发明公开
    MONOCLONAL ANTIBODY DIRECTED AGAINST CD166 AND METHOD FOR PRODUCTION THEREOF 有权
    反对CD166单克隆抗体导向和方法及其

    公开(公告)号：EP1956032A1

    公开(公告)日：2008-08-13

    申请号：EP06833466.3

    申请日：2006-11-28

    Applicant: Japan Science and Technology Agency ,  Osaka Prefecture University

    Inventor： TSUKAMOTO, Yasuhiro

    IPC: C07K16/42 ,  C12N5/10 ,  C12P21/08 ,  G01N33/574 ,  G01N33/577

    CPC classification number: G01N33/57488 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/73 ,  G01N2333/70503

    Abstract: CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166.
    The antibody was prepared by immunizing mice with a purified avian CD 166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.

    Abstract translation: CD166是属于免疫球蛋白的并在在肿瘤表面上过量的过表达超家族细胞粘附分子。 如果特异性结合CD166单克隆抗体获得，它能够抑制肿瘤细胞的生长，检测所述细胞中，并且具体地提供到其上的治疗药物。 然而，由于CD166蛋白是哺乳动物中非常相似的海誓山盟，它有什么不可能获得在抗体对人CD166，通过免疫，例如小鼠与人类CD166。 其通过与纯化的禽CD 166蛋白免疫小鼠制备的抗体。 其中发现该抗体对人和小鼠CD166蛋白在体外以及在体内被吸收并会对动作来抑制小鼠中的肿瘤生长。

    DETECTION OF BACTERIUM BELONGING TO THE GENUS CAMPYLOBACTER WHICH TARGETS CYTOLETHAL DISTENDING TOXIN
    135.
    发明公开
    DETECTION OF BACTERIUM BELONGING TO THE GENUS CAMPYLOBACTER WHICH TARGETS CYTOLETHAL DISTENDING TOXIN 审中-公开
    检测细胞周期延长毒素的属细菌的检测

    公开(公告)号：EP3255148A1

    公开(公告)日：2017-12-13

    申请号：EP17180547.6

    申请日：2008-08-29

    Applicant: Osaka Prefecture University ,  Fuso Pharmaceutical Industries, Ltd.

    Inventor： Yamasaki, Shinji ,  Samosorunsuk, Worada ,  Asakura, Masahiro

    IPC: C12N15/09 ,  C07K14/205 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/569

    CPC classification number: C12Q1/689 ,  C07K16/1203 ,  C07K16/121 ,  C07K2317/76 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/56922 ,  G01N2333/205 ,  Y02A50/451

    Abstract: An objective of the present invention is to provide the cytolethal distending toxin (CDT) of C . hyointestinalis and polynucleotides encoding it, and novel methods for detection of C . hyointestinalis using the cdt genes.
    The present inventors focused on the cytolethal distending toxin (CDT) of Campylobacter bacteria, and detected the cdt genes of a Campylobacter -like bacterium isolated from an enteritis patient in Thailand. The present inventors discovered a bacterial strain whose cdtB gene was amplified by common primers in C. jejuni , C. coli, and C . fetus, but not by multiplex PCR that can specifically detect the cdtA , cdtB , and cdtC genes of the three bacterial species. The bacterial strain was identified as C . hyointestinalis by 16S rRNA gene analysis. Furthermore, the entire nucleotide sequence of the cdt genes was determined by genome walking upstream and downstream of the cdtB gene.

    Abstract translation: 本发明的一个目的是提供豚肠弯曲杆菌的细胞致密扩张毒素（CDT）和编码它的多核苷酸，以及使用cdt基因检测豚肠弯曲杆菌的新方法。 本发明人专注于弯曲杆菌属的细胞致密扩张毒素（CDT），并检测了从泰国的肠炎患者分离的弯曲杆菌样细菌的cdt基因。 本发明人发现了通过空肠弯曲杆菌，大肠弯曲杆菌和C.胎儿的普通引物扩增cdtB基因的菌株，但没有通过能够特异性检测三种细菌的cdtA，cdtB和cdtC基因的多重PCR 种类。 通过16S rRNA基因分析将该菌株鉴定为豚肠弯曲杆菌。 此外，cdt基因的整个核苷酸序列通过基因组在cdtB基因的上游和下游行走来确定。

    DETECTION OF BACTERIUM BELONGING TO GENUS CAMPYLOBACTER WHICH TARGETS CYTOLETHAL DISTENDING TOXIN
    137.
    发明授权
    DETECTION OF BACTERIUM BELONGING TO GENUS CAMPYLOBACTER WHICH TARGETS CYTOLETHAL DISTENDING TOXIN 有权
    靶向细胞间距不等的毒蛋白检测细菌

    公开(公告)号：EP2192184B1

    公开(公告)日：2017-08-09

    申请号：EP08828171.2

    申请日：2008-08-29

    Applicant: Osaka Prefecture University ,  Fuso Pharmaceutical Industries, Inc.

    Inventor： YAMASAKI, Shinji ,  SAMOSORUNSUK, Worada Dep. of Med. Tech., ,  ASAKURA, Masahiro

    IPC: C12N15/09 ,  C07K14/205 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/569

    CPC classification number: C12Q1/689 ,  C07K16/1203 ,  C07K16/121 ,  C07K2317/76 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/56922 ,  G01N2333/205 ,  Y02A50/451

    Abstract: An objective of the present invention is to provide the cytolethal distending toxin (CDT) of C . hyointestinalis and polynucleotides encoding it, and novel methods for detection of C . hyointestinalis using the cdt genes. The present inventors focused on the cytolethal distending toxin (CDT) of Campylobacter bacteria, and detected the cdt genes of a Campylobacter -like bacterium isolated from an enteritis patient in Thailand. The present inventors discovered a bacterial strain whose cdtB gene was amplified by common primers in C. jejuni , C. coli, and C . fetus, but not by multiplex PCR that can specifically detect the cdtA , cdtB , and cdtC genes of the three bacterial species. The bacterial strain was identified as C . hyointestinalis by 16S rRNA gene analysis. Furthermore, the entire nucleotide sequence of the cdt genes was determined by genome walking upstream and downstream of the cdtB gene.

    Abstract translation: 本发明的一个目的是提供豚肠弯曲杆菌的细胞致密扩张毒素（CDT）和编码它的多核苷酸，以及使用cdt基因检测豚肠弯曲杆菌的新方法。 本发明人致力于弯曲杆菌属的细胞致密扩张毒素（CDT），并检测了从泰国的肠炎患者分离的弯曲杆菌样细菌的cdt基因。 本发明人发现了通过空肠弯曲杆菌，大肠弯曲杆菌和C.胎儿的普通引物扩增cdtB基因的菌株，但没有通过能够特异性检测三种细菌的cdtA，cdtB和cdtC基因的多重PCR 种类。 通过16S rRNA基因分析将该菌株鉴定为豚肠弯曲杆菌。 此外，cdt基因的整个核苷酸序列通过基因组在cdtB基因的上游和下游行走来确定。

    ORGANIC IRIDIUM COMPLEX FOR ORGANIC ELECTROLUMINESCENT ELEMENTS
    138.
    发明公开
    ORGANIC IRIDIUM COMPLEX FOR ORGANIC ELECTROLUMINESCENT ELEMENTS 审中-公开
    用于有机电致发光元件的有机铱络合物

    公开(公告)号：EP3187503A1

    公开(公告)日：2017-07-05

    申请号：EP15835168.4

    申请日：2015-08-26

    Applicant: Tanaka Kikinzoku Kogyo K.K. ,  Osaka Prefecture University Public Corporation

    Inventor： MASAHIRO, Yasushi ,  YAGI, Shigeyuki ,  TANIUCHI, Junichi

    IPC: C07F15/00 ,  C09K11/06 ,  H01L51/50

    CPC classification number: H01L51/0085 ,  C07F15/00 ,  C07F15/0033 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/185 ,  H01L51/50 ,  H01L51/5016

    Abstract: The present invention provides an organometallic complex having a high quantum efficiency even in a polymer thin film as a emitting material for organic electroluminescent (EL) element. The present invention relates to an organoiridium complex for an organic electroluminescent element represented by the following Formula; wherein a C-N ligand including two atomic groups (A 1 , A 2 ), and a β-diketone) ligand in line symmetry having two tert-butyl-substituted phenyl groups are coordinated with an iridium atom. The organoiridium complex of the present invention has a high quantum efficiency even in a polymer thin film with respect to green to yellow electroluminescence.

    (In the aforementioned Formula, R 1 , R 2 , and R 3 are each a tert-butyl group or a hydrogen atom, and have at least one tert-butyl group; they may bond each other to thereby form a saturated hydrocarbon ring, when having two tert-butyl groups; A 1 , A 2 are each an unsaturated hydrocarbon ring, at least one is a single ring, and at least one is a heterocyclic ring.)

    Abstract translation: 本发明提供即使在作为有机电致发光（EL）元件的发光材料的聚合物薄膜中也具有高量子效率的有机金属配合物。 本发明涉及由下式表示的用于有机电致发光元件的有机铱络合物; 其中包含两个原子团（A1，A2）的C-N配体和具有两个叔丁基取代的苯基的线对称的β-二酮配体与铱原子配位。 本发明的有机铱络合物即使在绿色至黄色电致发光的聚合物薄膜中也具有高量子效率。 （式中，R 1，R 2和R 3分别为叔丁基或氢原子，并且具有至少一个叔丁基;当具有两个时，它们可以彼此键合从而形成饱和烃环 叔丁基; A1，A2各自为不饱和烃环，至少一个为单环，并且至少一个为杂环。）

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