公开(公告)号：WO2015085143A3

公开(公告)日：2015-07-30

申请号：PCT/US2014068739

申请日：2014-12-05

Applicant: STC UNM

Inventor： VANDER JAGT DAVID L ,  DECK LORRAINE M ,  ROYER ROBERT E ,  HEIDRICH JOHN E

IPC: A61K31/136 ,  A61K31/05 ,  A61K31/085 ,  A61P17/00 ,  A61P35/00

CPC classification number: A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans- stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

Abstract translation: 本发明涉及治疗患有皮肤疾病或病症的受试者的方法，所述方法包括向需要的受试者或患者施用包含治疗有效量的取代的顺式或反式二苯乙烯或二苯乙烯的组合物 混合。 治疗或减少患者皮肤疾病或病症的可能性的方法是本发明的另外的实施方案。 本发明优选的药物组合物包括含有治疗有效量的取代的顺式或反式二苯乙烯或芪混合物和至少一种抗生素的纳米乳剂。

公开(公告)号：WO2012149376A3

公开(公告)日：2013-01-17

申请号：PCT/US2012035529

申请日：2012-04-27

Applicant: STC UNM ,  SANDIA CORP ,  BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

Inventor： BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

IPC: A61K9/16 ,  A61K38/17 ,  A61K47/30 ,  A61K47/48 ,  A61K48/00

CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内源性逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：WO2012142246A3

公开(公告)日：2012-12-27

申请号：PCT/US2012033260

申请日：2012-04-12

Applicant: STC UNM ,  TIMMINS GRAHAM ,  WU TERRY ,  CHOI SEONG WON

Inventor： TIMMINS GRAHAM ,  WU TERRY ,  CHOI SEONG WON

IPC: C12Q1/04 ,  C07C229/08 ,  G01N33/497 ,  G01N33/58

CPC classification number: C12Q1/04 ,  C07B59/001 ,  C07B2200/05 ,  C07B2200/07 ,  C07C275/16 ,  C12Q2304/46 ,  C12Q2304/48

Abstract: The present invention is directed to the use of isotopically labeled citrulline for gnosing the presence or absence of a bacterial infection in the lungs of a patient.

Abstract translation: 本发明涉及同位素标记的瓜氨酸用于在患者肺中引发细菌感染存在或不存在的用途。

公开(公告)号：WO2012064972A3

公开(公告)日：2012-08-02

申请号：PCT/US2011060211

申请日：2011-11-10

Applicant: STC UNM ,  LESEMAN ZAYD ,  LUHRS CLAUDIA ,  PHILLIPS JONATHAN ,  SOLIMAN HAYTHAM

Inventor： LESEMAN ZAYD ,  LUHRS CLAUDIA ,  PHILLIPS JONATHAN ,  SOLIMAN HAYTHAM

IPC: B22F9/22 ,  B22F9/18 ,  B82B3/00 ,  B82Y40/00

CPC classification number: B22F9/26 ,  B22F1/0018 ,  B22F1/0096 ,  B22F9/22 ,  B33Y40/00 ,  B82Y40/00

Abstract: Various embodiments provide methods of forming zero valent metal particles using an aerosol- reductive/expansion synthesis (A-RES) process, in one embodiment, an aerosol stream including metal precursor compound(s) and chemical agent(s) that produces reducing gases upon thermal decomposition can be introduced into a heated inert atmosphere of a RES reactor to form zero valent metal particles corresponding to metals used for the metal precursor compound(s).

Abstract translation: 各种实施方式提供了使用气溶胶还原/膨胀合成（A-RES）方法形成零价金属颗粒的方法，在一个实施方式中，气溶胶流包括金属前体化合物和一种或多种化学试剂， 可以将热分解引入到RES反应器的加热的惰性气氛中以形成对应于用于金属前体化合物的金属的零价金属颗粒。

公开(公告)号：WO2011116226A3

公开(公告)日：2012-04-05

申请号：PCT/US2011028875

申请日：2011-03-17

Applicant: STC UNM ,  PEABODY DAVID S ,  CHACKERIAN BRYCE

Inventor： PEABODY DAVID S ,  CHACKERIAN BRYCE

IPC: C07K16/10 ,  A61K39/42 ,  A61P35/00 ,  C12N7/01 ,  C12N15/09 ,  C12Q1/68

CPC classification number: C12N15/1037 ,  C07K16/005 ,  C07K2317/622 ,  C07K2319/00 ,  C12N7/00 ,  C12N2795/16023 ,  C12N2795/16061 ,  C12N2795/18023 ,  C12N2795/18061

Abstract: The invention enables the display of antibody single-chain variable fragments (scFv's on virus-like particles (VLPs) of bacteriophages such as MS2. The VLPs encapsidate mRNA encoding the coat protein from which it assembles, enabling the recovery by reverse transcription and PGR of affinity-selected sequences from scFv libraries. Related virus-like particles, method for constructing a library of scFv-VLPs, drug delivery vehicles comprising one or more pharmaceutically-active ingredients, biomedical imaging agents, assays, and kits are also provided.

Abstract translation: 本发明能够显示抗体单链可变片段（scFv在噬菌体如MS2的病毒样颗粒（VLP）上），VLP包裹编码其组装的外壳蛋白的mRNA，使得能够通过逆转录和PGR 还提供了相关病毒样颗粒，用于构建scFv-VLPs文库的方法，包含一种或多种药物活性成分的药物递送载体，生物医学成像剂，测定法和试剂盒。

公开(公告)号：WO2012009484A2

公开(公告)日：2012-01-19

申请号：PCT/US2011043922

申请日：2011-07-13

Applicant: STC UNM ,  WHITTEN DAVID ,  SCHANZE KIRK ,  PARTHSARAY ANAND ,  JI EUNKYUNG ,  OGAWA MOTOKATSU ,  CORBITT THOMAS ,  DASCIER DIMITRI ,  WANG YING ,  ISTA LINNEA

Inventor： WHITTEN DAVID ,  SCHANZE KIRK ,  PARTHSARAY ANAND ,  JI EUNKYUNG ,  OGAWA MOTOKATSU ,  CORBITT THOMAS ,  DASCIER DIMITRI ,  WANG YING ,  ISTA LINNEA

IPC: C08G61/02 ,  C08J5/00 ,  C08L65/00

CPC classification number: C07D487/08 ,  C07C217/14 ,  C07C217/20 ,  C07C309/11 ,  C07C309/24 ,  C07D333/16 ,  C08G61/02 ,  C08G61/126 ,  C08G75/00 ,  C08G2261/312 ,  C08G2261/3223 ,  C08G2261/3328 ,  C08G2261/3422 ,  C08G2261/93

Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Abstract translation: 本公开提供了新型聚（亚苯基亚乙炔基）（PPE）化合物，合成这些化合物的方法以及掺入这些化合物的材料和物质。 各种PPE显示出抗菌，抗病毒和抗真菌活性。

公开(公告)号：WO2010045631A3

公开(公告)日：2010-08-05

申请号：PCT/US2009061127

申请日：2009-10-19

Applicant: STC UNM ,  SUBHADRA BOBBAN

Inventor： SUBHADRA BOBBAN

IPC: C12N1/12 ,  C12M1/00 ,  C12P5/00

CPC classification number: C12P7/649 ,  C12M21/02 ,  C12M23/04 ,  C12M33/14 ,  C12M43/02 ,  C12P7/18 ,  C12P7/20 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472 ,  C12P21/00 ,  Y02E50/13 ,  Y02P20/134

Abstract: Methods and apparatus for growing and sequentially processing algae to produce a variety of products including but not limited to biofuels, algal meal, oil, unsaturated fatty acids and recombinant proteins and peptides in a cost-effective and energy efficient manner. Also provided are methods of use for the products.

Abstract translation: 用于生长和依次加工藻类以以成本有效和节能的方式生产多种产品，包括但不限于生物燃料，藻粉，油，不饱和脂肪酸和重组蛋白质和肽的方法和装置。 还提供了用于产品的方法。

公开(公告)号：WO2010033288A3

公开(公告)日：2010-07-01

申请号：PCT/US2009049205

申请日：2009-06-30

Applicant: STC UNM ,  KISSEL DAVID J ,  BRINKER CHARLES JEFFREY

Inventor： KISSEL DAVID J ,  BRINKER CHARLES JEFFREY

IPC: C09D133/04 ,  B05D5/00 ,  B05D7/00 ,  C09D5/00 ,  C09D183/02

CPC classification number: C09D7/1225 ,  A01N55/00 ,  C08K3/36 ,  C08K9/06 ,  C09D5/006 ,  C09D5/14 ,  C09D5/165 ,  C09D5/1681 ,  C09D7/62 ,  C09D133/12 ,  D06N3/0043 ,  D06N3/0063 ,  D10B2401/10 ,  D10B2401/13 ,  Y10T428/249953 ,  Y10T428/249972 ,  Y10T428/24999 ,  Y10T428/249991 ,  Y10T442/20

Abstract: Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Abstract translation: 提供了聚合物 - 气凝胶复合涂层，包括聚合物 - 气凝胶复合涂层的装置和制品，以及制备聚合物 - 气凝胶复合物的方法。 该示例性制品可以包括表面，其中该表面包括至少一个区域和设置在该至少一个区域上方的聚合物 - 气凝胶复合涂层，其中聚合物 - 气凝胶复合涂层具有至少约140°的水接触角和 小于约1°的接触角滞后。 聚合物 - 气凝胶复合涂层可以包括聚合物和超高含水量催化聚硅酸盐气凝胶，聚硅酸盐气凝胶包括具有用甲硅烷基化试剂和多个孔衍生的表面官能团的二氧化硅颗粒的三维网络。

公开(公告)号：WO2010027510A2

公开(公告)日：2010-03-11

申请号：PCT/US2009005042

申请日：2009-09-08

Applicant: STC UNM ,  WANG WEI

Inventor： WANG WEI

IPC: C07D207/335 ,  C07D207/10 ,  C07D207/12 ,  C07D207/337

CPC classification number: C07D207/08

Abstract: The invention provides direct processes and related catalysts for the syntheses of trisubstituted chiral pyrrolidines, piperidines, tetrahydrothiophenes, and thianes by highly enantio- and diastereoselective cascade Michael-Michael reaction of a, ß-unsaturatedaldehydes with /ra/25-?-protected amino a, ß-unsaturated esters.

Abstract translation: 本发明提供了直接方法和相关催化剂，用于通过α，β-不饱和醛与α-ra / 25-β-保护的氨基α的高度对映体和非对映选择性级联迈克尔 - 迈克尔反应来合成三取代的手性吡咯烷，哌啶，四氢噻吩和噻烷 ，β-不饱和酯。

公开(公告)号：WO2009158146A3

公开(公告)日：2010-03-04

申请号：PCT/US2009045835

申请日：2009-06-01

Applicant: STC UNM ,  CHEN JINGKUANG

Inventor： CHEN JINGKUANG

IPC: G01N29/00 ,  A61B8/00 ,  G01N21/00

CPC classification number: A61B5/0095 ,  A61B5/0048 ,  A61B5/0091 ,  A61B5/0093 ,  A61B5/4312 ,  A61B8/44 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/02 ,  A61B2562/028 ,  G01N21/1702 ,  G01N29/24 ,  G01N29/2406 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2291/02475 ,  G01N2291/106

Abstract: A photoacoustic imaging device includes an array of light sources configured and arranged to illuminate a target region and an array of ultrasonic transducers between the array of light sources and the target region. The array of transducers may be fixedly coupled to the array of light sources, and the array of ultrasonic transducers may be configured and arranged to receive ultrasound transmissions from the target region.

Abstract translation: 光声成像装置包括配置和布置成在光源阵列和目标区域之间照射目标区域和超声波换能器阵列的光源阵列。 换能器阵列可以固定地耦合到光源阵列，并且超声换能器阵列可以被配置和布置成从目标区域接收超声波传输。