公开(公告)号：US20200207868A1

公开(公告)日：2020-07-02

申请号：US16637201

申请日：2018-08-09

Applicant: University of Saskatchewan

Inventor： Bharathikumar Vellalore Maruthachalam ,  Aynan Elsayed Mohammad ,  Jianghai Liu ,  Humphrey Fonge ,  Kris Barreto ,  Clarence Ronald Geyer

IPC: C07K16/32 ,  A61K9/00 ,  A61K47/64 ,  A61K49/00 ,  G01N33/574

Abstract: The disclosure is directed to antibodies and binding fragments thereof that specifically bind HER3. The disclosure is further directed to immunoconjugates comprising the antibodies and binding fragments thereof that specifically bind HER3. The disclosure is also directed to uses of the antibodies, binding fragments thereof and immunoconjugates for detecting HER3-expressing cells and for treating HER3-expressing cancer.

公开(公告)号：US10098944B2

公开(公告)日：2018-10-16

申请号：US15218748

申请日：2016-07-25

Applicant: University of Saskatchewan

Inventor： Yan Zhou ,  Aleksandar Masic

IPC: A01N63/00 ,  A61K38/00 ,  A61K39/12 ,  A61K39/225 ,  C12N15/861 ,  A61K39/145 ,  C12N7/00 ,  A61K39/00

Abstract: Recombinant, chimeric porcine influenza viruses are disclosed that include hemagglutinin segments from more than one influenza virus subtype. Also described are methods of producing the recombinant influenza viruses, immunogenic compositions comprising the recombinant influenza viruses, methods of stimulating an immune response against influenza virus, and methods of treating and preventing influenza virus infection.

公开(公告)号：US20170233779A1

公开(公告)日：2017-08-17

申请号：US15438291

申请日：2017-02-21

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12P17/06 ,  C12N15/70 ,  C12N15/52 ,  C12P7/42 ,  C12P7/22

CPC classification number: C12P17/06 ,  C12N9/1025 ,  C12N15/52 ,  C12N15/70 ,  C12N15/8243 ,  C12P7/22 ,  C12P7/42 ,  C12Y203/01206 ,  C12Y404/01026 ,  Y02P20/52

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US20170190755A1

公开(公告)日：2017-07-06

申请号：US15451731

申请日：2017-03-07

Applicant: University of Saskatchewan

Inventor： Scott Kirk Napper ,  Kenneth Jason Kindrachuk ,  Samuel Kwadwo Attah-Poku

IPC: C07K14/47 ,  A61K39/39

CPC classification number: C07K14/4723 ,  A61K38/00 ,  A61K39/0002 ,  A61K39/0008 ,  A61K39/002 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/572 ,  C07K2319/00

Abstract: Compositions and methods are provided for modulating an immune response in a vertebrate subject. Compositions and methods can comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to activate the immune response in the vertebrate subject, wherein the modified host defense peptide is inverted in amino acid sequence from an amino terminus to a carboxy terminus or modified to one or more D-amino acids, or both modifications, when compared to a host defense peptide. Compositions and methods are provided which comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to modify an immune response in the vertebrate subject.

公开(公告)号：US09687001B2

公开(公告)日：2017-06-27

申请号：US15063350

申请日：2016-03-07

Applicant: University Of Saskatchewan

Inventor： Vladimir Vujanovic ,  James J. Germida

IPC: A01N63/04 ,  A01H17/00 ,  A01N63/02 ,  B09C1/10 ,  A01N63/00 ,  C12R1/80 ,  C12R1/465 ,  C12R1/645

CPC classification number: A01N63/04 ,  A01H17/00 ,  A01N63/00 ,  A01N63/02 ,  B09C1/105 ,  C12R1/465 ,  C12R1/645 ,  C12R1/80 ,  A01N25/00

Abstract: The present disclosure provides compositions comprising novel endophytes capable of promoting germination endophytes that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

公开(公告)号：US09669016B2

公开(公告)日：2017-06-06

申请号：US15193589

申请日：2016-06-27

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Rosa A. Maldonado ,  Miguel A. Vasquez ,  Jonathan R. Dimmock ,  Umashankar Das

IPC: A61K31/13 ,  A61K31/4545 ,  A61K45/06 ,  A61K31/132

CPC classification number: A61K31/4545 ,  A61K31/13 ,  A61K31/132 ,  A61K45/06 ,  Y02A50/409 ,  Y02A50/414

Abstract: Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.

公开(公告)号：US09593287B2

公开(公告)日：2017-03-14

申请号：US14729128

申请日：2015-06-03

Applicant: University of Saskatchewan

Inventor： Ajay Kumar Dalai ,  Rajesh Vishnudev Sharma

IPC: C10M105/32 ,  C10M121/04 ,  C10M129/68 ,  C11C3/00 ,  C11C1/06 ,  C10M105/36 ,  C10M177/00 ,  C10M105/42 ,  C11C3/08

CPC classification number: C10M105/36 ,  C10M105/42 ,  C10M177/00 ,  C11C3/08

Abstract: A process for producing a lubricant from an epoxy-triglyceride comprising treating the epoxy-triglyceride with an esterifying agent in the presence of a heterogeneous catalyst under conditions to produce the lubricant is disclosed.

Abstract translation: 公开了一种从环氧甘油三酸酯制备润滑剂的方法，包括在非均相催化剂存在下用酯化剂处理环氧甘油三酯以制备润滑剂。

公开(公告)号：US20170022514A1

公开(公告)日：2017-01-26

申请号：US15284730

申请日：2016-10-04

Applicant: University of Saskatchewan

Inventor： Curtis J. POZNIAK ,  Pierre HUCL

IPC: C12N15/82 ,  C12Q1/68 ,  A01N43/50 ,  C12N9/88

CPC classification number: C12N15/8274 ,  A01H5/10 ,  A01N43/50 ,  C12N9/88 ,  C12N15/8278 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156 ,  C12Y401/03

Abstract: The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants containing one or more IMI nucleic acids such as a Teal IMI cultivar. The nucleic acids are preferably located on or derived from different genomes. The present invention also includes seeds produced by these wheat plants and methods of controlling weeds in the vicinity of these wheat plants.

Abstract translation: 本发明涉及对咪唑啉酮除草剂具有增加的抗性的小麦植物。 更具体地，本发明包括含有一种或多种IMI核酸如小麦IMI品种的小麦植物。 核酸优选位于不同基因组上或衍生自不同基因组。 本发明还包括由这些小麦植物生产的种子以及在这些小麦植物附近控制杂草的方法。

公开(公告)号：US20170000903A1

公开(公告)日：2017-01-05

申请号：US15100111

申请日：2014-11-27

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Andrew A. OLKOWSKI ,  Bernard LAARVELD

IPC: A61K47/48 ,  A61K47/38 ,  A61K47/46 ,  A23L33/10 ,  C08J3/03 ,  C08L91/00 ,  A61K31/4164 ,  C09B69/10 ,  A61K9/107 ,  C08J3/075

CPC classification number: A61K31/4164 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/107 ,  A61K47/38 ,  A61K47/46 ,  A61K47/6949 ,  C07C407/00 ,  C08B3/04 ,  C08H8/00 ,  C08J3/03 ,  C08J3/075 ,  C08J2391/00 ,  C08J2401/02 ,  C08L1/04 ,  C08L91/00 ,  C08L2201/52 ,  C08L2203/02 ,  C09B69/10 ,  Y02A50/411 ,  C07C409/24

Abstract: Crystalline cellulose gels useful in the stabilization of emulsions, including nanoemulsions, and for acting as cryptands or clathrates, and methods for their use and production are provided. In some embodiments, the emulsion is an oil-in-water emulsion. In some embodiments, such emulsions and/or vesicles produced in such emulsions, and/or the crystalline cellulose gel itself 15 are useful in the fields of drug delivery, pharmaceuticals, cosmetics, feed and food, paints and coatings, mining, or oil and gas recovery.

Abstract translation: 提供了可用于稳定乳液（包括纳米乳剂）和作为穴状物或包合物的结晶纤维素凝胶及其使用和生产方法。 在一些实施方案中，乳液是水包油乳液。 在一些实施方案中，在这种乳液中制备的这种乳液和/或囊泡和/或结晶纤维素凝胶本身15可用于药物递送，药物，化妆品，饲料和食品，油漆和涂料，采矿或油的领域 天然气回收。

公开(公告)号：US20160355444A1

公开(公告)日：2016-12-08

申请号：US15109064

申请日：2014-12-31

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Andrew A. OLKOWSKI ,  Bernard LAARVELD

IPC: C05F3/00 ,  C05D1/00 ,  C08H7/00 ,  C02F1/72 ,  C08B37/00 ,  D21C11/00 ,  C02F1/66 ,  C05F3/06 ,  C08B15/02

CPC classification number: C05F3/00 ,  C02F1/66 ,  C02F1/722 ,  C02F1/725 ,  C02F9/00 ,  C02F11/12 ,  C02F2103/20 ,  C02F2209/06 ,  C05D1/00 ,  C05F3/06 ,  C05F9/04 ,  C05F11/00 ,  C08B15/02 ,  C08B37/00 ,  C08B37/14 ,  C08H6/00 ,  C08H8/00 ,  C08L97/005 ,  C08L97/02 ,  D21C11/00 ,  D21C11/0007 ,  Y02A40/205 ,  Y02A40/208 ,  Y02A40/216 ,  Y02P20/145

Abstract: A process for producing desired compounds from biomass, including treating a lignocellulosic waste stream in some embodiments. The waste stream is conditioned under acidic or basic conditions, and is then treated in a catalytic reaction step using a transition metal catalyst and an oxidant. The transition metal catalyst can be an iron-based nanoparticulate catalyst. In some embodiments, useful compounds such as lignin, crystalline cellulose and various platform chemicals are produced from the waste stream. In some embodiments, the waste stream is lignocellulosic agricultural or forestry waste. In some embodiments, the waste stream is manure. In some embodiments, desirable bioproducts are obtained from lignocellulosic biomasses using an iron-based nanoparticulate-catalyzed reaction conducted at alkaline pH.

Abstract translation: 在一些实施方案中，从生物质产生所需化合物的方法，包括处理木质纤维素废物流。 废物流在酸性或碱性条件下调节，然后在催化反应步骤中使用过渡金属催化剂和氧化剂进行处理。 过渡金属催化剂可以是铁基纳米颗粒催化剂。 在一些实施方案中，从废物流产生有用的化合物，例如木质素，结晶纤维素和各种平台化学品。 在一些实施方案中，废物流是木质纤维素农业或林业废物。 在一些实施方案中，废物流是肥料。 在一些实施方案中，使用在碱性pH下进行的铁基纳米颗粒催化反应从木质纤维素生物质获得所需的生物产物。