公开(公告)号：US20200207868A1

公开(公告)日：2020-07-02

申请号：US16637201

申请日：2018-08-09

Applicant: University of Saskatchewan

Inventor： Bharathikumar Vellalore Maruthachalam ,  Aynan Elsayed Mohammad ,  Jianghai Liu ,  Humphrey Fonge ,  Kris Barreto ,  Clarence Ronald Geyer

IPC: C07K16/32 ,  A61K9/00 ,  A61K47/64 ,  A61K49/00 ,  G01N33/574

Abstract: The disclosure is directed to antibodies and binding fragments thereof that specifically bind HER3. The disclosure is further directed to immunoconjugates comprising the antibodies and binding fragments thereof that specifically bind HER3. The disclosure is also directed to uses of the antibodies, binding fragments thereof and immunoconjugates for detecting HER3-expressing cells and for treating HER3-expressing cancer.