Angiopep and derivatives thereof for imaging amyloids

    公开(公告)号:US10258699B2

    公开(公告)日:2019-04-16

    申请号:US15520516

    申请日:2014-10-24

    Abstract: The present application relates to the molecular labeling and in vivo imaging of amyloids. Specifically, the present application relates to a polypeptide-based method/vector for targeting amyloids. Such a method/vector enables the transportation of compounds or drugs across blood-brain-barrier of an individual and then binding to amyloids in brain. Particularly, the vector of the present application can transport an imaging group linked to the vector across the blood-brain-barrier, and can binds to amyloids in brain, and thus enables the labeling and imaging of amyloid deposits. When used as an imaging agent for detecting amyloid deposits in body or tissues, the vector may be labeled with suitable optical imaging groups, radioactive isotopes or imaging groups suitable for MRI or CT detection. The method/vector can especially used for the in vivo non-invasive diagnosis of amyloid-related diseases including Alzheimer's disease, and for the observation of the therapeutic effect of drugs targeting amyloid deposits.

    HEAT DISSIPATION APPARATUS AND COMMUNICATIONS DEVICE

    公开(公告)号:US20190075680A1

    公开(公告)日:2019-03-07

    申请号:US16179563

    申请日:2018-11-02

    Abstract: Embodiments of the present invention provide a heat dissipation apparatus. Wherein a loop coil is disposed on a swing plate. A first magnet and a second magnet are located on two sides of the loop coil, and when a current whose direction periodically varies flows through the loop coil, an Ampere force whose direction periodically varies is applied to the loop coil under an action of a magnetic field formed by the first magnet and the second magnet, so that the loop coil drives the swing plate to swing back and forth. The present invention is used for heat dissipation of a micro electronic component.

    Method and system for simultaneous information and energy transfer with a guard interval signal

    公开(公告)号:US10211957B2

    公开(公告)日:2019-02-19

    申请号:US15831072

    申请日:2017-12-04

    Abstract: A simultaneous information and energy transfer method and system with a guard interval signal are provided. The method comprises the steps of generating, by a transmitting terminal, a controllable guard interval signal according to the current energy demand and environment conditions for channel transmission. The system comprises a transmitting terminal configured to generate a controllable guard interval signal. In the system and method, the guard interval time is fully utilized to transfer a guard interval signal with controllable amount of energy, which not only prevents intersymbol interference, but also provides controllable energy signals within the guard interval time at the same time, thus improving the energy transfer performance of the system and reducing the probability that the receiving terminal is unable to operate normally due to energy shortage. The present invention can be widely applied to a variety of simultaneous wireless information and energy transfer systems.

    TASK SCHEDULING METHOD AND APPARATUS ON HETEROGENEOUS MULTI-CORE RECONFIGURABLE COMPUTING PLATFORM

    公开(公告)号:US20170315846A1

    公开(公告)日:2017-11-02

    申请号:US15650608

    申请日:2017-07-14

    Abstract: Embodiments of the present invention provide a task scheduling method and apparatus on a heterogeneous multi-core reconfigurable computing platform. The method includes: when determining that a to-be-executed hardware task is in a ready state, adding the to-be-executed hardware task into a target hardware task queue corresponding to a function of the to-be-executed hardware task; reconfiguring, according to a priority of the to-be-executed hardware task and a usage status of multiple reconfigurable resource packages, at least one reconfigurable resource package in the multiple reconfigurable resource packages into a target intellectual property IP core that can execute the to-be-executed hardware task. According to the embodiments of the present invention, a more proper resource reconfiguration occasion can be determined, and a more appropriate reconfigurable resource package can be used for resource reconfiguration, thereby reducing reconfiguration overheads and improving utilization of reconfigurable resources in a task scheduling process.

    ANGIOPEP AND DERIVATIVES THEREOF FOR IMAGING AMYLOIDS

    公开(公告)号:US20170304469A1

    公开(公告)日:2017-10-26

    申请号:US15520516

    申请日:2014-10-24

    CPC classification number: A61K49/0056 A61K49/0032 A61K49/0043 A61K51/088

    Abstract: The present application relates to the molecular labeling and in vivo imaging of amyloids. Specifically, the present application relates to a polypeptide-based method/vector for targeting amyloids. Such a method/vector enables the transportation of compounds or drugs across blood-brain-barrier of an individual and then binding to amyloids in brain. Particularly, the vector of the present application can transport an imaging group linked to the vector across the blood-brain-barrier, and can binds to amyloids in brain, and thus enables the labeling and imaging of amyloid deposits. When used as an imaging agent for detecting amyloid deposits in body or tissues, the vector may be labeled with suitable optical imaging groups, radioactive isotopes or imaging groups suitable for MRI or CT detection. The method/vector can especially used for the in vivo non-invasive diagnosis of amyloid-related diseases including Alzheimer's disease, and for the observation of the therapeutic effect of drugs targeting amyloid deposits.

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