公开(公告)号：EP0699235A1

公开(公告)日：1996-03-06

申请号：EP94917988.0

申请日：1994-05-13

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： REISNER, Yair

IPC: A01K67 ,  A61K35 ,  A61K39 ,  C07K16 ,  C12N5 ,  G01N33

CPC classification number: A61K35/28 ,  A01K67/0271 ,  A61K35/38 ,  A61K35/407 ,  C07K16/109

Abstract: A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.

公开(公告)号：EP0617705A1

公开(公告)日：1994-10-05

申请号：EP92925312.0

申请日：1992-11-19

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： LIDER, Ofer ,  GREENSPOON, Noam ,  HERSHKOVIZ, Rami ,  RONEN, Alon

IPC: A61K31 ,  A61P7 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07C279 ,  C07C323 ,  C07D211 ,  C07K5 ,  A61K38

CPC classification number: C07K5/06026 ,  A61K38/00 ,  C07C279/08 ,  C07C279/12 ,  C07C279/14 ,  C07C323/44 ,  C07D211/60 ,  C07K5/0202 ,  C07K5/06086 ,  Y10S514/822

Abstract: Des analogues RXD non peptidiques inhibent des interactions moléculaires et cellulaires biologiques qui dépendent de la reconnaissance de RXD, X représentant l'un des restes d'amino acides G, E, Y, A ou F. En particulier les succédanés RGD n'ont pas de séquences d'amino acides alpha-naturels et comprennent un groupe guanidino et un groupe terminal carboxyle espacés par une chaîne de 11 atomes, dont au moins 5 sont des atomes de carbone. Les composés empêchent l'adhésion des cellules et sont utiles pour le traitement de divers états pathologiques, par exemple, la thrombose, les maladies autoimmunes, les métastases, les allergies, les réactions hôtes-greffes et empêchent la formation de tissu cicatriciel.

Abstract translation: 非肽RXD类似物抑制依赖于RXD识别的分子和细胞细胞相互作用，其中X代表氨基酸残基G，E，Y，A或F中的一个。特别地，RGD替代物不 的α-天然氨基酸序列并且包含间隔有11个原子链的胍基和羧基端基，其中至少5个是碳原子。 该化合物可防止细胞粘附，并可用于治疗各种疾病状态，例如血栓形成，自身免疫性疾病，转移，变态反应，宿主 - 移植物反应并防止疤痕组织形成。

公开(公告)号：EP0583050A2

公开(公告)日：1994-02-16

申请号：EP93303308.6

申请日：1993-04-28

Applicant: AMGEN INC. ,  YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Wen, Duanzhi ,  Peles, Elior ,  Yarden, Yosef

IPC: C12N15/12 ,  C07K13/00 ,  A61K37/02 ,  C12P21/08 ,  G01N33/577 ,  C12N5/10 ,  C12N1/21

CPC classification number: C07K14/4756 ,  A61K38/00

Abstract: Recombinant neu receptor stimulating factor, analogs of the factor, DNA sequences encoding the same, and methods of production are disclosed. Pharmaceutical compositions and methods of treating disorders involving neu receptor expression are also described.

Abstract translation: 公开了重组neu受体刺激因子，该因子的类似物，编码该因子的DNA序列和生产方法。 还描述了治疗涉及neu受体表达的病症的药物组合物和方法。

公开(公告)号：EP0332679B1

公开(公告)日：1993-06-16

申请号：EP88907908.3

申请日：1988-08-03

Applicant: NEW YORK UNIVERSITY ,  YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： LAVIE, David ,  MERUELO, Daniel ,  LAVIE, Gad ,  REVEL, Michel, c/o Weizman Institute of Science ,  VANDE VELDE, Vincent ,  ROTMAN, Dalia

IPC: A61K31/12

CPC classification number: A61K31/12

Abstract: Pharmaceutical formulations comprising aromatic polycyclic dione compounds useful for treating mammals suffering from diseases caused by retroviruses are disclosed herein. A method for treating mammals suffering from retrovirus infections is also disclosed.

公开(公告)号：EP0504904A3

公开(公告)日：1993-03-17

申请号：EP92104822.9

申请日：1992-03-19

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Kedem, Ora ,  Warshawsky, Abraham

IPC: B01D61/44 ,  B01D69/10 ,  B01D71/68 ,  C08J5/22

CPC classification number: B01D61/445 ,  C08J5/2275 ,  C08J2381/06

Abstract: A supported, mechanically stable bipolar membrane (1) for electrodialysis having a cation-exchange layer on one side and an anion-exchange layer on the other side of a single sheet of woven fabric. The cation exchange layer is heterogeneous, the anion exchange layer is homogeneous and the two are interlocked. A process of making such bipolar membranes is described. The bipolar membrane may be fabricated into electrodialysis cells in which two membranes are joined along their edges.

公开(公告)号：EP0106434B1

公开(公告)日：1992-05-06

申请号：EP83303611.4

申请日：1983-06-22

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Patchornik, Abraham ,  Shai, Yechiel ,  Pass, Shimeon

IPC: C07B43/00 ,  C07B43/06 ,  C07K1/04 ,  C07H21/00 ,  B01J19/00

CPC classification number: C07H21/00 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00391 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00698 ,  B01J2219/0072 ,  C07C249/16 ,  C07D303/38 ,  C07F7/1852 ,  C07F9/094 ,  C40B60/14 ,  C07C251/86

公开(公告)号：EP0217102B1

公开(公告)日：1992-01-08

申请号：EP86111585.5

申请日：1986-08-21

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Revel, Michel ,  Chebath, JudithC/O Dept. of Virology

IPC: C12N15/52 ,  C12N9/00 ,  C07K7/10 ,  C12Q1/68 ,  G01N33/573

CPC classification number: C12N9/93 ,  C12Q1/6897 ,  G01N33/573 ,  Y10S435/81 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/813 ,  Y10S530/806

公开(公告)号：EP0412486A1

公开(公告)日：1991-02-13

申请号：EP90115105.0

申请日：1990-08-06

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Wallach, David ,  Engelmann, Harmut ,  Aderka, Dan

IPC: C12P21/08 ,  A61K39/395 ,  G01N33/577 ,  G01N33/68 ,  C07K3/18

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151

Abstract: Antibodies to TNF Binding Protein I (TBP-I) and F(ab) fragments thereof are provided that can be used in diagnostic assays and pharmaceutical agents for either inhibiting or mimicking the effects of TNF on cells.

Abstract translation: 提供了针对TNF结合蛋白I（TBP-1）和F（ab）片段的抗体，其可用于诊断测定和用于抑制或模拟TNF对细胞的作用的药物。

公开(公告)号：EP0324496A3

公开(公告)日：1991-01-02

申请号：EP89100540.7

申请日：1989-01-13

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Friesem, Asher Albert ,  Amitai, Yaakov

IPC: G03H1/04 ,  G02B5/32 ,  G02B27/00

CPC classification number: G02B5/32 ,  G02B27/0103 ,  G02B27/0172 ,  G02B2027/0107 ,  G02B2027/0109 ,  G02B2027/0145 ,  G03H1/04

Abstract: A method of producing a desired hologram for a holographic optical element for use in imaging a multi-dimensional array of points, in which two coherent recording beams are utilized to produce an interference pattern which is recorded to form the desired hologram, characterized in that one or both of the recording beams have an aspherical wavefront derived from one or more intermediate holograms each reconstructed by the use of a read out beam having a geometry and/or wavelength different from the beams for recording the respective intermediate hologram.

公开(公告)号：EP0353632A3

公开(公告)日：1990-08-08

申请号：EP89113874.5

申请日：1989-07-27

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Vager, Zeev ,  Naaman, Ron

IPC: H01J1/32

CPC classification number: H01J1/32 ,  H01J43/24 ,  H01J2231/12

Abstract: An electron multiplier including a multi-layer arrangement of material which provides secondary electron emissions when impinged upon by electrons and apparatus for applying an electric field across the material. A cathode ray tube, and devices incorporating a cathode ray tube, such as televisions and oscilloscopes are also provided in accordance with the invention.