公开(公告)号：EP0105221B1

公开(公告)日：1987-03-25

申请号：EP83108837.2

申请日：1983-09-07

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Revel, Michel ,  Wallach, David

IPC: G01N33/68 ,  G01N33/569

CPC classification number: C12Q1/70 ,  G01N33/56983 ,  G01N33/6866 ,  Y10S435/84 ,  Y10S435/975 ,  Y10S436/804 ,  Y10S436/808 ,  Y10S436/828

公开(公告)号：EP0217102B1

公开(公告)日：1992-01-08

申请号：EP86111585.5

申请日：1986-08-21

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Revel, Michel ,  Chebath, JudithC/O Dept. of Virology

IPC: C12N15/52 ,  C12N9/00 ,  C07K7/10 ,  C12Q1/68 ,  G01N33/573

CPC classification number: C12N9/93 ,  C12Q1/6897 ,  G01N33/573 ,  Y10S435/81 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/813 ,  Y10S530/806

公开(公告)号：EP0217102A1

公开(公告)日：1987-04-08

申请号：EP86111585.5

申请日：1986-08-21

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Revel, Michel ,  Chebath, JudithC/O Dept. of Virology

IPC: C12N15/52 ,  C12N9/00 ,  C07K7/10 ,  C12Q1/68 ,  G01N33/573

CPC classification number: C12N9/93 ,  C12Q1/6897 ,  G01N33/573 ,  Y10S435/81 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/813 ,  Y10S530/806

Abstract: The present invention relates to a human DNA sequence coding for an enzyme having (2'-5') oligo A synthetase activity, a 1.6 kb RNA and a 1.8 kb RNA being complementary to the mentioned DNA sequences, to a DNA transfer vector, comprising an inserted DNA sequence consisting essentially of the mentioned DNA sequence, furthermore to a microorganism which has been transformed by the said transfer vector and is capable of expressing an enzyme having the (2'-5') oligo A synthetase activity. The present invention furthermore provides a method of monitoring the response of a patient to an interferon, which comprises measuring the concentration of (2'-5') oligo A synthetase mRNA in cells or body fluids of the patient by hybridizing the mRNA to DNA complementary thereto. In addition there are provided antigenic peptides and antibodies raised against the antigenic peptides which recognises and immunoprecipitates (2'-5') oligo A synthetase.

Abstract translation: 本发明涉及编码具有（2分钟-5分钟）寡聚A合成酶活性的酶的DNA DNA序列，与所述DNA序列互补的1.6kb RNA和1.8kb RNA的DNA转移载体，其包含 基本上由所述DNA序列组成的插入DNA序列，此外还与已经通过所述转移载体转化并能够表达具有（2分钟-5分钟）寡聚A合成酶活性的酶的微生物。 本发明还提供了一种监测患者对干扰素的反应的方法，其包括通过将mRNA与DNA互补来测量患者细胞或体液中（2分钟-5分钟）寡聚A合成酶mRNA的浓度 于此。 此外，还提供抗原肽和针对抗原肽产生的抗体，其识别和免疫沉淀（2分钟-5分钟）寡聚A合成酶。

公开(公告)号：EP0105221A1

公开(公告)日：1984-04-11

申请号：EP83108837.2

申请日：1983-09-07

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Revel, Michel ,  Wallach, David

IPC: G01N33/68 ,  G01N33/569

CPC classification number: C12Q1/70 ,  G01N33/56983 ,  G01N33/6866 ,  Y10S435/84 ,  Y10S435/975 ,  Y10S436/804 ,  Y10S436/808 ,  Y10S436/828

Abstract: There is provided an assay for the detection and quantitative determination of interferon. The assay is based on the exposure of certain cells to a solution containing the interferon which is to be determined, infecting the cells with a suitable virus, incubating for a predetermined period of time, lysing the infected cultures and determining the virus protein. The measurement of the virus proteins can be effected by ELISA or Radioimmunoassay. There is also provided a kitfor carrying out such assays.

公开(公告)号：EP1780277A1

公开(公告)日：2007-05-02

申请号：EP06021361.8

申请日：1998-01-15

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Abramovich, Carolina ,  Chebat, Judith ,  Revel, Michel

IPC: C12N15/12

CPC classification number: C12N9/1007 ,  A61K38/21 ,  C07K14/4702 ,  A61K2300/00

Abstract: Novel proteins IR 1B1 and IR 1B4 have been isolated which bind to the type I IFN receptor IRNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the protein can be used for isolation of the new protein or for immunodetection thereof.

Abstract translation: 新的蛋白质IR 1B1和1B4 IR havebeen分离其结合到干扰素的细胞应答I型IFN受体IRNAR1类型和功能。 在有义或反义方向编码检查蛋白质的DNA可以施用以增强的任一个或抑制对干扰素的细胞响应。 抗体与蛋白可用于新的蛋白质的分离或用于其免疫检测。