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公开(公告)号：US20170306049A1
公开(公告)日：2017-10-26
申请号：US15508112
申请日：2015-09-08
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Yosef YARDEN , Nadège GABORIT , Moshit LINDZEN
IPC: C07K16/32 , G01N33/574 , C07K16/30 , A61K39/00
Abstract: An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a KD value of 10 nM or lower, wherein the polypeptide inhibits neuregulin (NRG) binding to the human HERS and NRG-induced cancer cell migration and proliferation.
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公开(公告)号：US20170298361A1
公开(公告)日：2017-10-19
申请号：US15516405
申请日：2015-10-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yosef SHAUL , Rom David KESHET , Nina REUVEN
IPC: C12N15/113 , A61K31/506 , A61K31/553
CPC classification number: C12N15/1137 , A61K31/506 , A61K31/553 , C12N2310/14 , C12N2310/531
Abstract: Use of agents that down-regulates an amount and/or activity of Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or checkpoint kinase 1 (Chk1) in the production of a medicament for treating obesity are disclosed.
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公开(公告)号：US20170294572A1
公开(公告)日：2017-10-12
申请号：US15128609
申请日：2015-03-25
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventor： Ron NAAMAN , Nirit KANTOR-URIEL , Shinto P. MATHEW , Yossef PALTIEL , Oren BEN-DOR , Shira YOCHELIS , Nir PEER
CPC classification number: H01L43/04 , G01R33/07 , G01R33/091 , G11C11/16 , G11C11/161 , G11C11/18 , G11C13/0014 , G11C13/04 , G11C13/043 , H01L43/065 , H03K19/18
Abstract: An electronic device is presented, the device comprises: a spin accumulating structure; a spin selective filter electrically connected at a first end thereof to a first surface of said spin accumulating layer structure; a charge carrier source attached to said spin selective filter at a second end of the spin selective filter; wherein the spin selective filter is configured to allow passage of the charge carriers having a predetermined spin orientation from the charge carrier source to the spin accumulating structure, thereby causing a variation of spin distribution of the charge carriers within the spin accumulating structure. The device comprises further at least first and second pairs of electrical contacts which are connected to the spin accumulating structure and define first and second electrical paths through said spin accumulating structure, said first and second electrical paths intersecting within said spin accumulating structure. The device including a circuit configured to apply an electrical current between the first pair of electrical contacts and to detect the variation of spin-distribution of charge carriers within the spin accumulating structure by determining electrical voltage between the second pair of electrical contacts in response to the applied electrical current.
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公开(公告)号：US09738685B2
公开(公告)日：2017-08-22
申请号：US15017049
申请日：2016-02-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Milstein , Chidambaram Gunanathan , Yehoshua Ben-David , Ekambaram Balaraman , Boopathy Gnanaprakasam , Jing Zhang
IPC: C07K5/12 , C07C209/50 , C07C213/00 , C07C231/00 , C07C231/02 , C07D307/52 , C08L79/02 , C07C67/03 , C07C45/00 , C07C51/235 , C07C67/28 , C07D241/12 , C07D295/185 , C07D487/14 , C07C29/136 , C07C67/39 , C07K1/02 , C07K1/10
CPC classification number: C07K5/12 , C07C29/136 , C07C45/002 , C07C51/235 , C07C67/03 , C07C67/28 , C07C67/39 , C07C209/50 , C07C213/00 , C07C231/00 , C07C231/02 , C07C2601/08 , C07C2601/14 , C07D241/12 , C07D295/185 , C07D307/52 , C07D487/14 , C07K1/02 , C07K1/10 , C08L79/02 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C235/10 , C07C233/36 , C07C211/27 , C07C215/28 , C08L1/00 , C07C69/14 , C07C69/24 , C07C31/04 , C07C31/08 , C07C31/10 , C07C31/12
Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.
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公开(公告)号：US20170233702A1
公开(公告)日：2017-08-17
申请号：US15498493
申请日：2017-04-27
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rony SEGER , Alexander PLOTNIKOV
IPC: C12N9/12
CPC classification number: C12N9/12 , A61K38/00 , A61K38/12 , A61K47/64 , C12N9/1205 , C12Y207/11 , C12Y207/11024
Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.
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Patent Agency Ranking
136.发明申请公开(公告)号：US20170210823A1
公开(公告)日：2017-07-27
申请号：US15328036
申请日：2014-07-24
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Irit SAGI , Moran GROSSMAN , Nir BEN-CHETRIT
IPC: C07K16/40 , A61K45/06 , A61K33/24 , A61K39/395
CPC classification number: C07K16/40 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.
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公开(公告)号：US09696310B2
公开(公告)日：2017-07-04
申请号：US14738894
申请日：2015-06-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Margulies , Leila Motiei , Linor Unger
IPC: C07D417/14 , G01N33/573 , C07D417/06 , C09K11/06 , G01N33/58 , C07F9/6541 , C07K7/06 , G01N33/574
CPC classification number: G01N33/573 , C07D417/06 , C07D417/14 , C07F9/6541 , C07K7/06 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , G01N33/574 , G01N33/582 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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公开(公告)号：US20170183665A1
公开(公告)日：2017-06-29
申请号：US15312734
申请日：2015-05-21
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ron MILO , Niv ANTONOVSKY , Elad NOOR , Arren BAR-EVEN , Yehudit ZOHAR , Lior ZELCBUCH , Shmuel GLEIZER , Shira AMRAM
CPC classification number: C12N15/70 , C07K14/195 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12N9/88 , C12N9/90 , C12Y101/01049 , C12Y203/03009 , C12Y207/01011 , C12Y207/01019 , C12Y401/01039 , C12Y402/01011 , C12Y504/02
Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
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139.发明申请公开(公告)号：US20170172979A1
公开(公告)日：2017-06-22
申请号：US15118196
申请日：2015-02-18
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Menachem RUBINSTEIN , Efrat DVASH-RIESENFELD
IPC: A61K31/366 , A61K31/381 , A61K31/41
CPC classification number: A61K31/366 , A61K31/166 , A61K31/192 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/426 , A61K31/47 , A61K2300/00
Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.
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公开(公告)号：US20170141835A1
公开(公告)日：2017-05-18
申请号：US15346747
申请日：2016-11-09
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Avishay Gal-Yam , Barak Zackay , Eran Ofek
CPC classification number: H04B7/0851 , H04B17/20 , H04B17/318 , H04B17/3912
Abstract: A method for detecting a dispersed pulse in a received signal that has been dispersed by a dispersive medium includes obtaining an input army of cells, each indicating an intensity of a frequency component of the signal at a representative time. A fast dispersion measure transform (FDMT) is applied to concurrently sum the cells of the input array that lie along different dispersion curves, each curve defined by a known non-linear functional form and being uniquely characterized by a time coordinate and by a value of the dispersion measure. Application of FDMT includes initially generating a plurality of sub-arrays, each representing a frequency sub-band and iteratively combining pairs of adjacent sub-arrays in accordance with an addition rule until all of the initially generated plurality of sub-arrays are combined into an output army of the sums, in which a cell of the output array that is indicative of a transmitted pulse is identified.
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