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公开(公告)号：KR1020140120841A
公开(公告)日：2014-10-14
申请号：KR1020140038804
申请日：2014-04-01
Applicant: (주)아모레퍼시픽
IPC: A61K36/258 , A61P43/00
CPC classification number: A61K36/258 , A23L1/28 , A23L2/52 , A23L33/105 , A61K31/704 , A61K45/06 , A61K2300/00
Abstract: 본 발명은 수명 연장용 조성물에 관한 것으로, 구체적으로는 인삼 열매의 추출물을 포함하는 수명 연장용 조성물에 관한 것이다.
Abstract translation: 本发明涉及一种延长寿命的组合物，更具体地，涉及一种含有人参水果提取物的延长寿命组合物。 根据本发明，作为组合物的活性成分的人参果实提取物降低死亡率并延长与人类具有高遗传均质性的果蝇和秀丽隐杆线虫的寿命。 因此，本发明可延长哺乳动物的寿命。
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公开(公告)号：KR1020140112203A
公开(公告)日：2014-09-23
申请号：KR1020130026604
申请日：2013-03-13
Applicant: (주)아모레퍼시픽
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N33/6893 , G01N2333/4703 , G01N2500/00 , G01N2800/207 , A61K8/64 , A61Q19/02 , C12Q1/68
Abstract: The present invention relates to a method for screening a test substance having whitening efficacy and, more specifically, to a method for screening a test substance having whitening efficacy by checking whether or not the test substance activates Forkhead box O3A (FoxO3a) or promotes the expression thereof using FoxO3a which is a longevity gene, and thereby determining whether or not the test substance has whitening efficacy.
Abstract translation: 本发明涉及一种筛选具有增白效果的试验物质的方法，更具体地说，涉及通过检查试验物质是否活化Forkhead盒O3A（FoxO3a）或促进表达来筛选具有增白功效的试验物质的方法 使用作为长寿基因的FoxO3a，从而确定被检物质是否具有美白效果。
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公开(公告)号：KR1020140093305A
公开(公告)日：2014-07-28
申请号：KR1020130002005
申请日：2013-01-08
Applicant: (주)아모레퍼시픽
IPC: G01N33/68 , G01N33/53 , G01N33/532
Abstract: The present invention relates to a method for detecting skin-active ingredients and a kit for detecting the skin-active ingredients using the same, and, more specifically, to a method for detecting skin-active ingredients which separates and purifies candidates for inducing expression of cytokine genes or proteins by activating skin immune cells using the cytokine genes or proteins that are produced and secreted from active skin immune cells, thereby detecting the skin-active ingredients including ingredients such as whitening ingredients or blackening ingredients for alleviating hypochromic and hyperchromic diseases.
Abstract translation: 本发明涉及一种检测皮肤活性成分的方法和用于检测皮肤活性成分的试剂盒，更具体地说，涉及一种分离和纯化诱导表达的候选物质的皮肤活性成分的方法 通过使用从活性皮肤免疫细胞产生和分泌的细胞因子基因或蛋白质来激活皮肤免疫细胞，从而检测皮肤活性成分，包括诸如增白成分或变黑成分的成分，以减轻低色素和变色疾病，从而检测细胞因子基因或蛋白质。
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公开(公告)号：KR1020140064593A
公开(公告)日：2014-05-28
申请号：KR1020130040842
申请日：2013-04-15
Applicant: (주)아모레퍼시픽
Abstract: The specification provides a light source irradiator which irradiates visible light, a kit for lipolysis with a manual described with a method for lipolysis by irradiating visible light, and a slimming method for irradiating visible light to the skin. According to the specification, the method can safely and effectively dissolve fat by dissolving triglyceride in fat cells by irradiating light with a visible light wavelength harmless to a human body and can be used for a slimming method since the method is more economical and convenient than an existing lipolysis method.
Abstract translation: 本说明书提供了照射可见光的光源照射器，用用于通过照射可见光的脂肪分解方法描述的手动进行脂肪分解的试剂盒，以及用于将可见光照射到皮肤上的减肥方法。 根据本说明书，该方法可以通过用对人体无害的可见光波长的光照射而将甘油三酯溶解在脂肪细胞中而可以安全有效地溶解脂肪，并且可以用于减肥方法，因为该方法比一种方法更经济和方便 现有脂肪分解法。
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公开(公告)号：KR1020140034595A
公开(公告)日：2014-03-20
申请号：KR1020120101126
申请日：2012-09-12
Applicant: (주)아모레퍼시픽
IPC: A61K31/19 , A61K31/192 , A61K8/36 , A61Q19/02
Abstract: A composition for external skin application which comprises dehydroabietic acid as an active ingredient for skin whitening of the present invention can be usefully applied as a composition for external skin application with a purpose of skin whitening since effects of tyrosinase activity reduction and melanin generation reduction are excellent. The composition for external skin application contains 0.000025-0.025 wt% of the dehydroabietic acid compared to a total weight of the composition. [Reference numerals] (AA) Comparative example 1; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract translation: 包含脱氢松香酸作为本发明的皮肤美白的活性成分的外用皮肤用组合物，作为皮肤美白用的外用皮肤用组合物，可以有用地应用，因为酪氨酸酶活性降低和黑色素产生降低的效果优异 。 与组合物的总重量相比，用于外用皮肤的组合物含有脱氢枞酸的0.000025-0.025wt％。 （附图标记）（AA）比较例1; （BB）实施例1; （CC）实施例2; （DD）实施例3
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Patent Agency Ranking
公开(公告)号：KR1020130117445A
公开(公告)日：2013-10-28
申请号：KR1020120039939
申请日：2012-04-17
Applicant: (주)아모레퍼시픽
IPC: A61K8/49 , A61K31/352 , A61Q19/02 , A61P17/00
CPC classification number: A61K8/498 , A23L29/035 , A23V2200/318 , A61K31/353 , A61Q19/02
Abstract: PURPOSE: A whitening composition containing 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is provided to suppress the activity of tyrosinase and melanogenesis, thereby showing superior whitening effect. CONSTITUTION: A whitening composition contains 0.000025-0.025 wt% of Trolox of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The active ingredient suppresses the activity of tyrosinase and dopaoxidase and generation of 3,4-dihydroxyphenylalanine (DOPA).
Abstract translation: 目的：提供含有6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸（Trolox）的美白组合物，以抑制酪氨酸酶的活性和黑素生成，从而显示优异的美白效果。 构成：增白组合物含有0.000025-0.025重量％的化学式1的Trolox，其衍生物或其药学上可接受的盐作为活性成分。 活性成分抑制酪氨酸酶和多巴胺酶的活性和3,4-二羟基苯丙氨酸（DOPA）的产生。
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公开(公告)号：KR1020130093983A
公开(公告)日：2013-08-23
申请号：KR1020120015273
申请日：2012-02-15
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An antioxidant screening method is provided to include a step of evaluating an extent that DAF-16 moves to a nucleus in an animal treated with candidate material, thereby easily and simply screening material having an excellent antioxidant effect in a short time. CONSTITUTION: An antioxidant screening method comprises: a step of treating an animal with candidate material; and a step of evaluating an extent that DAF-16 moves to a nucleus in the animal treated with the candidate material. The animal includes caenorhabditis elegans. The animal is caenorhabditis elegans which includes DAF-16 labeled by fluorescence.
Abstract translation: 目的：提供抗氧化剂筛选方法，包括评估DAF-16移动到用候选材料处理的动物中的核的程度的步骤，从而容易且简单地筛选在短时间内具有优异抗氧化作用的材料。 构成：抗氧化剂筛选方法包括：用候选物质处理动物的步骤; 以及评估DAF-16移动到用候选材料处理的动物中的核的程度的步骤。 动物包括秀丽隐杆线虫。 动物是秀丽隐杆线虫，其中包括通过荧光标记的DAF-16。
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公开(公告)号：KR101572219B1
公开(公告)日：2015-11-30
申请号：KR1020130137700
申请日：2013-11-13
Applicant: 한국과학기술원 , 충남대학교산학협력단 , 한국기초과학지원연구원
CPC classification number: C12N15/1058 , C07K14/195 , C07K14/461 , C07K2318/20 , C12N15/1037 , C40B40/10
Abstract: 본발명은반복모듈을포함하는리피바디단백질의개량방법및 리피바디단백질개량을위한리피바디라이브러리를코딩하는뉴클레오티드라이브러리에관한것으로, 더욱자세하게는리피바디단백질을구성하는반복모듈을순차적으로변이시키는모듈진화방법을이용한리피바디단백질의개량방법및 상기단백질개량에사용되는리피바디라이브러리를코딩하는뉴클레오티드라이브러리에관한것이다. 본발명에따른모듈진화방법에의하면, 높은결합친화도를가지고이에따른특이도및 활성이증가된개량된리피바디단백질을스크리닝할수 있어, 타겟물질에대한억제제, 치료제및 분석수단으로사용되는리피바디를개발하는데에용이하다.
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公开(公告)号：KR1020150055397A
公开(公告)日：2015-05-21
申请号：KR1020130137700
申请日：2013-11-13
Applicant: 한국과학기술원 , 충남대학교산학협력단 , 한국기초과학지원연구원
CPC classification number: C12N15/1058 , C07K14/195 , C07K14/461 , C07K2318/20 , C12N15/1037 , C40B40/10
Abstract: 본발명은반복모듈을포함하는리피바디단백질의개량방법및 리피바디단백질개량을위한리피바디라이브러리를코딩하는뉴클레오티드라이브러리에관한것으로, 더욱자세하게는리피바디단백질을구성하는반복모듈을순차적으로변이시키는모듈진화방법을이용한리피바디단백질의개량방법및 상기단백질개량에사용되는리피바디라이브러리를코딩하는뉴클레오티드라이브러리에관한것이다. 본발명에따른모듈진화방법에의하면, 높은결합친화도를가지고이에따른특이도및 활성이증가된개량된리피바디단백질을스크리닝할수 있어, 타겟물질에대한억제제, 치료제및 분석수단으로사용되는리피바디를개발하는데에용이하다.
Abstract translation: 本发明涉及一种用于改进重复体蛋白质的方法，包括重复模块和用于改进重组体蛋白质的编码重复体的文库的核苷酸库编码方法，更具体地说，涉及通过使用用于连续改变重复模块的模块进化方法来改进重组体蛋白质的方法 重复体蛋白质和编码用于改善重组体蛋白质的重组体文库的核苷酸文库编码，其中允许模块进化方法筛选具有高结合亲和力并因此增加特异性和活性的改进的重组体蛋白质，从而用于开发所使用的重组体 用于靶物质的抑制剂，药物和分析工具。
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公开(公告)号：KR101517196B1
公开(公告)日：2015-05-04
申请号：KR1020130007380
申请日：2013-01-23
Applicant: 한국과학기술원 , 충남대학교산학협력단 , 한국기초과학지원연구원
Abstract: 본 발명은 인터루킨-6과의 특이적인 결합을 통해 그의 생물학적 활성을 억제할 수 있는 신규한 폴리펩타이드, 상기 폴리펩타이드를 코딩하는 폴리뉴클레오타이드, 상기 폴리뉴클레오타이드를 포함하는 벡터, 상기 벡터가 도입된 형질전환체, 상기 형질전환체를 이용하여 상기 폴리펩타이드를 생산하는 방법, 상기 폴리펩타이드를 포함하는 암 예방 또는 치료용 조성물 및 상기 폴리펩타이드를 포함하는 암 예방 또는 치료용 조성물을 투여하는 것을 포함하는, 암을 예방 또는 치료하는 방법에 관한 것이다. 본 발명의 폴리펩타이드는 STAT3의 활성과 인터루킨-6의 농도를 유의하게 감소시키므로 IL-6 관련 질환의 예방 또는 치료용 제제로 널리 활용될 수 있다.
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