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    COMPOSITIONS CONTAINING GROWTH FACTORS AND ANTIMETABOLITES
    131.
    发明申请
    COMPOSITIONS CONTAINING GROWTH FACTORS AND ANTIMETABOLITES 审中-公开
    含有生长因子和抗微生物剂的组合物

    公开(公告)号：WO1995009003A1

    公开(公告)日：1995-04-06

    申请号：PCT/US1994011087

    申请日：1994-09-29

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  YORK, Billie, M. ,  NIXON, Jon, C.

    IPC: A61K38/18

    CPC classification number: A61K33/24 ,  A61K38/1841 ,  Y10S514/913 ,  A61K38/08 ,  A61K31/70 ,  A61K31/505 ,  A61K31/40 ,  A61K31/355 ,  A61K2300/00

    Abstract: The intraocular use of combinations of stromal cell growth stimulators (e.g., TGF- beta ) and antimetabolites (e.g., mitomycin C) in connection with glaucoma filtration surgery is described. The combination is applied to the surgical site to attract, mitogenically activate, and neutralize the potential for extracellular matrix synthesis leading to scar formation by stromal cells. Without such treatment, the formation of scar tissue may lead to impairment of the outflow of aqueous humor at the surgical site, particularly the fistula. The mitogenic activation of the stromal cells makes these cells susceptible to the antimetabolites. This enables the antimetabolites to suppress the proliferation of the fibroblasts and other associated stromal cells to a much greater extent, relative to the proliferation seen when the metabolites alone are utilized. The increased suppression of the proliferation and metabolism of these cells results in a significant improvement in the ability to prevent or retard the formation of scar tissue, and thereby reduces the incidence of fistula closure following glaucoma filtration surgery.

    Abstract translation: 描述了与青光眼过滤手术相关的基质细胞生长刺激剂（例如TGF-β）和抗代谢物（例如丝裂霉素C）的组合的眼内使用。 该组合应用于手术部位以吸引，有丝分裂活化并中和细胞外基质合成的潜力，导致基质细胞形成瘢痕。 没有这种治疗，瘢痕组织的形成可能导致手术部位，特别是瘘管的房水流出的损害。 基质细胞的有丝分裂活化使得这些细胞对抗代谢物敏感。 这使得抗代谢物相对于单独使用代谢物时所见的增殖，可以大大地抑制成纤维细胞和其它相关基质细胞的增殖。 对这些细胞的增殖和代谢的增加的抑制导致防止或延缓瘢痕组织形成的能力的显着改善，从而降低青光眼过滤手术后瘘闭合的发生率。

    TOPICAL OPHTHALMIC PHARMACEUTICAL VEHICLES
    132.
    发明申请
    TOPICAL OPHTHALMIC PHARMACEUTICAL VEHICLES 审中-公开
    局部OPHTHALMIC PHARMACEUTICAL车辆

    公开(公告)号：WO1995005804A1

    公开(公告)日：1995-03-02

    申请号：PCT/US1994002023

    申请日：1994-02-16

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  REED, Kenneth, W.

    IPC: A61K09/00

    CPC classification number: A61K9/0048

    Abstract: Universal ophthalmic pharmaceutical vehicles which increase in viscosity upon instillation in the eye are disclosed. Ophthalmic compositions of the universal vehicle and a pharmaceutically active drug are also disclosed. In one embodiment, the vehicle gels upon instillation in the eye. In another embodiment, suspension vehicles having superior physical stability are provided.

    Abstract translation: 公开了在滴眼时增加粘度的通用眼用药物载体。 还公开了通用载体的眼用组合物和药物活性药物。 在一个实施方案中，车辆在滴眼时凝胶化。 在另一个实施例中，提供了具有优异物理稳定性的悬架车辆。

    ANTI-INFLAMMATORY COMPOUNDS FOR OPHTHALMIC USE
    134.
    发明申请
    ANTI-INFLAMMATORY COMPOUNDS FOR OPHTHALMIC USE 审中-公开
    用于眼科用途的抗炎化合物

    公开(公告)号：WO1994026769A1

    公开(公告)日：1994-11-24

    申请号：PCT/US1993004671

    申请日：1993-05-17

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  BOLTRALIK, John, J.

    IPC: C07J05/00

    CPC classification number: C07J5/0076 ,  A61K31/56 ,  A61K31/57 ,  C07J9/00 ,  C07J31/006

    Abstract: Novel anti-inflammatory compounds, compositions of these compounds and use of such compounds to treat inflammed ocular tissue are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and are advantageously characterized in that they do not cause any significant increase in intraocular pressure during chronic use.

    Abstract translation: 描述了新型抗炎化合物，这些化合物的组合物和这些化合物用于治疗炎症性眼组织的用途。 这些化合物是已知类固醇化合物（例如地塞米松）的衍生物和类似物，有利的特征在于它们在慢性使用期间不会引起眼压的任何显着增加。

    COMPOSITIONS CONTAINING QUINOLONE ANTIBIOTICS AND SULFONATE OF POLYSTYROL
    137.
    发明申请
    COMPOSITIONS CONTAINING QUINOLONE ANTIBIOTICS AND SULFONATE OF POLYSTYROL 审中-公开
    含有喹啉酮抗生素和聚噻吩磺酸的组合物

    公开(公告)号：WO1993005816A1

    公开(公告)日：1993-04-01

    申请号：PCT/US1992007744

    申请日：1992-09-11

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  JANI, Rajni

    IPC: A61K47/48

    CPC classification number: A61K47/58 ,  Y10S514/912

    Abstract: Aqueous pharmaceutical compositions containing a synergistic combination of a quinolone and a polystyrene sulfonic acid polymer are described, wherein the compositions are clear solutions which are comfortable and have sustained release. Methods for use of the compositions are also disclosed. This type of formulation is particularly useful with ciprofloxacin-type quinolones by greatly increasing the solubility of these quinolones, making it feasible to have aqueous solutions containing such quinolones at or near physiological pH.

    Abstract translation: 描述了含有喹诺酮和聚苯乙烯磺酸聚合物的协同组合的含水药物组合物，其中所述组合物是舒适且持续释放的澄清溶液。 还公开了使用组合物的方法。 通过大大增加这些喹诺酮的溶解度，这种制剂对环丙沙星型喹诺酮特别有用，使得在生理pH附近或接近生理pH下使含有这种喹诺酮的水溶液成为可能。

    A MEANS, METHOD AND SYSTEM FOR STORAGE AND CARING FOR CONTACT LENSES
    139.
    发明申请
    A MEANS, METHOD AND SYSTEM FOR STORAGE AND CARING FOR CONTACT LENSES 审中-公开
    用于存储和保养接触镜片的手段，方法和系统

    公开(公告)号：WO1991011936A1

    公开(公告)日：1991-08-22

    申请号：PCT/US1990001186

    申请日：1990-03-05

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  CLEMENTS, Donald, A. ,  KENT, Michael, J. ,  FRONK, William, A.

    IPC: A45C11/04

    CPC classification number: A45C11/005 ,  A61L12/086

    Abstract: The present invention relates to a device and method for storing and caring for contact lenses, including a self-contained contact lens holder (12) to support and contain one or more contact lenses. A fluid conduit (28) is associated with the contact lens holder (12) to provide a pathway for fluid to the chamber or chambers (18 and/or 20) holding each contact lens. A fluid container (34) holding a fluid used in contact lens care is put in fluid communication with the fluid conduit (28) to selectively introduce fluid into the contact lens holder (12). In one embodiment of the invention, fluid can selectively be dispensed externally of the fluid container (34) and contact lens holder (12).

    Abstract translation: 本发明涉及一种用于存储和照顾隐形眼镜的装置和方法，包括用于支撑和容纳一个或多个隐形眼镜的独立隐形眼镜架（12）。 流体导管（28）与隐形眼镜保持器（12）相关联，以提供用于流体到保持每个隐形眼镜的腔室（18和/或20）的通路。 保持用于隐形眼镜护理的流体的流体容器（34）与流体导管（28）流体连通，以选择性地将流体引入隐形眼镜保持器（12）。 在本发明的一个实施例中，流体可以选择性地分配在流体容器（34）和隐形眼镜架（12）的外部。

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