公开(公告)号：WO1998026770A2

公开(公告)日：1998-06-25

申请号：PCT/US1997023185

申请日：1997-12-11

Applicant: ALCON LABORATORIES, INC. ,  GAMACHE, Daniel, A.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/00

CPC classification number: A61K31/5513 ,  A61K31/00 ,  A61K31/137 ,  A61K31/40 ,  A61K31/402 ,  A61K31/407 ,  A61K31/438 ,  A61K31/439 ,  A61K31/485 ,  A61K31/496 ,  A61K31/541 ,  A61K31/5415 ,  A61K31/55 ,  Y10S514/912

Abstract: Compositions and methods for treating ocular pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists topically for the prevention or alleviation of ocular pain.

Abstract translation: 公开了治疗眼痛的组合物和方法。 特别地，本发明公开了使用κ阿片样物质激动剂局部用于预防或减轻眼部疼痛的组合物和方法。

公开(公告)号：WO1998018485A1

公开(公告)日：1998-05-07

申请号：PCT/US1997016742

申请日：1997-09-19

Applicant: ALCON LABORATORIES, INC. ,  PANG, Iok-Hou ,  KAPIN, Michael, A. ,  DeSANTIS, Louis, Jr.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K38/57

CPC classification number: A61K38/55 ,  A61K31/192 ,  A61K38/57

Abstract: The invention provides pharmaceutical compositions containing calpain inhibitors and methods of using these calpain inhibitors to prevent or ameliorate ocular neural tissue disease or damage.

Abstract translation: 本发明提供含有钙蛋白酶抑制剂的药物组合物和使用这些钙蛋白酶抑制剂来预防或改善眼神经组织疾病或损伤的方法。

公开(公告)号：WO1997028769A1

公开(公告)日：1997-08-14

申请号：PCT/US1997000746

申请日：1997-01-09

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  INJEV, Valentine, P.

IPC: A61F09/007

CPC classification number: A61F9/00745 ,  A61B2017/320084 ,  A61M1/0084 ,  A61M39/1055

Abstract: An infusion sleeve having a two-piece body. The first piece is conical in shape and is attached to the handpiece by conventional methods. The distal end of the first piece contains a series of annular grooves. The second piece is tubular in shape and contains an annular rim or lip on the proximal end that interlocks within the annular grooves on the first piece.

Abstract translation: 输液套管，具有两件式的身体。 第一件是圆锥形的，并且通过常规方法附接到手持件上。 第一件的远端包含一系列环形槽。 第二件是管状的，并且包括在近端上的环形边缘或唇缘，其在第一件上的环形槽内互锁。

公开(公告)号：WO1997023225A1

公开(公告)日：1997-07-03

申请号：PCT/US1996018235

申请日：1996-11-15

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DEAN, Thomas, R. ,  HELLBERG, Mark ,  SALLEE, Verney, L.

IPC: A61K31/557

CPC classification number: A61K31/5585 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  A61K45/06 ,  Y10S514/913 ,  A61K2300/00

Abstract: Compositions containing DP-agonist and FP-agonists prostaglandin agonists and methods of their use in treating glaucoma or ocular hypertension are disclosed.

Abstract translation: 公开了含DP激动剂和FP-激动剂前列腺素激动剂的组合物及其用于治疗青光眼或高眼压症的方法。

公开(公告)号：WO1997023224A1

公开(公告)日：1997-07-03

申请号：PCT/US1996018068

申请日：1996-11-14

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DEAN, Thomas, R. ,  HELLBERG, Mark ,  SALLEE, Verney, L.

IPC: A61K31/557

CPC classification number: A61K31/559 ,  A61K31/5575 ,  A61K31/5585 ,  Y10S514/913

Abstract: Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.

Abstract translation: 公开了含有3-氧杂-D-前列腺素的组合物及其用于治疗青光眼或高眼压症的方法。

公开(公告)号：WO1997021391A1

公开(公告)日：1997-06-19

申请号：PCT/US1996018041

申请日：1996-11-12

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CASICA, Peter, D. ,  CHON, James, Y.

IPC: A61B19/00

CPC classification number: H01R13/72 ,  A61B18/14 ,  A61B50/20 ,  A61B90/50 ,  A61B2090/0813 ,  A61F9/00745 ,  Y10S439/909 ,  Y10T24/3444

Abstract: A surgical handpiece holder for use in protecting a surgical handpiece during storage or autoclaving, and providing a template for the storage of excess handpiece wire is disclosed.

Abstract translation: 公开了一种用于在储存或高压灭菌期间保护手术机头的外科手持架，并提供用于储存多余的手机线的模板。

公开(公告)号：WO1997018288A1

公开(公告)日：1997-05-22

申请号：PCT/US1996016050

申请日：1996-10-07

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ASGHARIAN, Bahram ,  HONG, Bor-Shyue ,  QUINTANA, Ronald, P.

IPC: C11D03/386

CPC classification number: C11D3/0078 ,  A61L12/145 ,  C11D3/386

Abstract: Compositions containing an ophthalmically acceptable, modified enzyme exhibiting a low pI and methods involving the combined use of these compositions with a polymeric antimicrobial agent, are disclosed for the simultaneous cleaning and disinfecting of contact lens.

Abstract translation: 公开了组合物，其包含显示低pI的眼科可接受的修饰酶和涉及将这些组合物与聚合抗微生物剂组合使用的方法，用于同时进行隐形眼镜的清洁和消毒。

公开(公告)号：WO1996040853A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009688

申请日：1996-06-07

Applicant: ALCON LABORATORIES, INC. ,  VAN DUZEE, Barry, F. ,  STONE, Ralph, P.

Inventor： ALCON LABORATORIES, INC.

IPC: C11D03/386

CPC classification number: C11D3/38663 ,  C11D3/0078

Abstract: Compositions containing an ophthalmically acceptable enzyme of high purity and integrity in a liquid medium and methods involving the use of these compositions for cleaning a contact lens, and in combination with an antimicrobial agent for the simultaneous cleaning and disinfecting of contact lens are disclosed.

Abstract translation: 公开了含有在液体介质中具有高纯度和完整性的眼科可接受的酶的组合物和涉及使用这些组合物用于清洁隐形眼镜的方法，以及与用于同时清洁和消毒隐形眼镜的抗微生物剂组合。

公开(公告)号：WO1996032131A1

公开(公告)日：1996-10-17

申请号：PCT/US1995004572

申请日：1995-04-14

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  NIXON, Jon, C. ,  YORK, Billie, M.

IPC: A61K38/18

CPC classification number: A61K38/1841

Abstract: The use of TGF- beta 3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF- beta 3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF- beta 3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.

Abstract translation: 描述了使用TGF-β3来减少由眼睛角膜创伤引起的瘢痕组织的形成。 本发明特别涉及使用TGF-β3来减少与涉及角膜的眼科手术相关的瘢痕组织的形成，例如角膜的激光照射。 将包含TGF-β3的组合物应用于创伤部位，以改变由成纤维细胞合成的细胞外基质的生成和组成，从而减少瘢痕组织的形成，从而减少视力。

公开(公告)号：WO1996022099A1

公开(公告)日：1996-07-25

申请号：PCT/US1995009144

申请日：1995-07-20

Applicant: ALCON LABORATORIES, INC. ,  MAY, Jesse, Albert

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/54

CPC classification number: C07D333/34 ,  A61K45/06 ,  C07D513/04

Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor. Methods for controlling elevated intraocular pressure with these compositions are also described.

Abstract translation: 描述了可用于控制与青光眼和眼高血压相关的升高的眼内压的眼用药物组合物。 组合物包含β-阻断剂和碳酸酐酶抑制剂的组合。 还描述了用这些组合物控制眼内压升高的方法。