公开(公告)号：CA2138289A1

公开(公告)日：1994-01-06

申请号：CA2138289

申请日：1993-06-08

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN ,  MUNSCHAUER RAINER

IPC: C07D513/04 ,  A61K20060101 ,  A61K31/33 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/54 ,  A61K31/542 ,  A61P25/00 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D207/00 ,  C07D209/02 ,  C07D209/52 ,  C07D221/00 ,  C07D239/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/00 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds having formula (1), in which Rl, R2. n, R3, A, X, Y and Z have the meaning given in the description, are disclosed, as well as their preparation. These new compounds are useful for controlling diseases.

公开(公告)号：NO934473D0

公开(公告)日：1993-12-08

申请号：NO934473

申请日：1993-12-08

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/395 ,  A61K31/40 ,  C07D20060101 ,  C07D209/52 ,  C07D221/22 ,  C07D

公开(公告)号：CA2138287C

公开(公告)日：2005-03-01

申请号：CA2138287

申请日：1993-06-08

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/445 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  A61P43/00 ,  C07D209/52 ,  C07D409/04 ,  A61K31/44 ,  C07D403/04

Abstract: Compounds of the formula I: (See formula I) in which the substituents have the meanings stated in the description, and their preparation are described. These novel compounds are suitable as neuroleptics, antidepressants, sedatives, hypnotics, CNS protectives or muscle relaxants.

公开(公告)号：SK283039B6

公开(公告)日：2003-02-04

申请号：SK23099

申请日：1997-08-22

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  BEHL BERTHOLD ,  KERRRIGAN FRANK ,  CHEETHAM SHARON

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14

Abstract: The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro- pyrid3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I), their physiologically acceptable salts and use in the therapy.

公开(公告)号：DE59410107D1

公开(公告)日：2002-05-23

申请号：DE59410107

申请日：1994-12-21

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  BEHL BERTHOLD ,  HOFMANN PETER

IPC: A61K31/495 ,  C07D401/14 ,  C07D403/04

Abstract: PCT No. PCT/EP94/03839 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 21, 1994 PCT Pub. No. WO96/19476 PCT Pub. Date Jun. 27, 1996Quinoxaline-2,3-(1H,4H)-diones of the formula I I and their tautomeric and enantiomeric forms and their physiologically tolerated salts, the variables R, R1 and R2 have the meanings specified in claim 1, and are useful for therapeutic treatment of neurodegenerative disorders, neurotoxic disturbances or as antiepileptics, antidepressants and anxiolytics; and drugs composed thereof.

公开(公告)号：CZ288896B6

公开(公告)日：2001-09-12

申请号：CZ75999

申请日：1997-08-22

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  BEHL BERTHOLD ,  CHEETHAM SHARON ,  KERRRIGAN FRANK

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14 ,  A61K31/4365 ,  A61K31/40

Abstract: In the present invention there are disclosed 3-substituted pyrido 3,4,5,6,7,8-hexahydro-pyrido (4 ,3 :4,5)thieno(2,3-d) pyrimidine derivatives of the general formula I, wherein the substituents have specific meanings and their salts with physiologically acceptable acids. These compounds are used for preparing medicaments intended for treating depressions and for inhibiting back absorption of serotonin. They are also used as selective antagonists.

公开(公告)号：DE59409813D1

公开(公告)日：2001-09-06

申请号：DE59409813

申请日：1994-03-19

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  BEHL BERTHOLD ,  HOFMANN HANS PETER

IPC: C07D487/04 ,  A61K31/495 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18

公开(公告)号：FI103667B1

公开(公告)日：1999-08-13

申请号：FI935399

申请日：1993-12-02

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/40 ,  C07D20060101 ,  C07D209/52

公开(公告)号：NO991132D0

公开(公告)日：1999-03-09

申请号：NO991132

申请日：1999-03-09

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  BEHL BERTHOLD ,  KERRIGAN FRANK ,  CHEETHAM SHARON

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14 ,  C07D221/00

Abstract: A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine compound of formula IwhereinR1 is hydrogen, C1-C4-alkyl, acetyl or benzoyl, optionally substituted phenyl-C1-C4-alkyl, naphthyl-C1-C3-alkyl, phenyl-C2-C3-alkanone or a phenylcarbamoyl-C2-alkyl,R2 is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,A is NH or oxygen,B is hydrogen or methyl,C is hydrogen, methyl or hydroxyl,X is nitrogen,Y is CH2, CH2-C2, CH2-C2-CH2 or CH2-CH,Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, andn is 2, 3 or 4,or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT1B and 5HT1A and for the treatment of depression and related disorders.

公开(公告)号：PL175485B1

公开(公告)日：1999-01-29

申请号：PL30148593

申请日：1993-12-14

Applicant: BASF AG

Inventor： UNGER LILIANE ,  STEINER GERD ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN ,  MUNSCHAUER RAINER

IPC: C07D403/02