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公开(公告)号:AU749539B2
公开(公告)日:2002-06-27
申请号:AU9068398
申请日:1998-07-23
Applicant: BASF AG
Inventor: STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , GARCIA-LADONA FRANCISCO JAVIER , EMLING FRANZ
IPC: A61K31/435 , A61P25/24 , C07D495/14
Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.
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公开(公告)号:SI0994865T1
公开(公告)日:2002-04-30
申请号:SI9830098
申请日:1998-07-03
Applicant: BASF AG
Inventor: STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , LE BRIS THEOPHILE-MARIE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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公开(公告)号:NO312154B1
公开(公告)日:2002-04-02
申请号:NO970164
申请日:1997-01-14
Applicant: BASF AG
Inventor: HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MUELLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D277/22 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/54 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/42 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/12 , A61P25/00
Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.
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公开(公告)号:NO312030B1
公开(公告)日:2002-03-04
申请号:NO970162
申请日:1997-01-14
Applicant: BASF AG
Inventor: HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12 , C07D239/28 , C07D403/12 , C07D403/14
Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号:NO311683B1
公开(公告)日:2002-01-07
申请号:NO970163
申请日:1997-01-14
Applicant: BASF AG
Inventor: HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MUELLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/415 , C07D233/84 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/445 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/73 , C07D213/79 , C07D213/81 , C07D233/90 , C07D307/79 , C07D333/24 , C07D333/28 , C07D333/38 , C07D471/18
Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号:BG63257B1
公开(公告)日:2001-07-31
申请号:BG10111097
申请日:1997-01-06
Applicant: BASF AG
Inventor: HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12
Abstract: The invention relates to pyrimidine compounds with the formula wherein the meanings of the substituents are shown in the description. The compounds have affinity to the dopamine D3-receptors and can be applied for the treatment of diseases which react to dopamine D3-receptor antagonists, or agonists, respectively. 20 claims
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7.
公开(公告)号:BG104291A
公开(公告)日:2001-05-31
申请号:BG10429100
申请日:2000-04-03
Applicant: BASF AG
Inventor: LUBISCH WILFRIED , DULLWEBER UTA , STARCK DOROTHEA , STEINER GERD , BACH ALFRED , EMLING FRANZ , GARCIA-LADONA XAVIER , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/519 , A61P1/00 , A61P1/14 , A61P3/04 , A61P5/00 , A61P9/12 , A61P15/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/00 , C07D471/04
Abstract: The invention relates to new 3-substituted tetrahydropyridopyrimidinone derivatives with the formula where the substituents have the meanings given in the Description, to methods for producing said derivatives, and to their use as medicamentous forms. 7 claims
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公开(公告)号:BG104151A
公开(公告)日:2000-10-31
申请号:BG10415100
申请日:2000-02-10
Applicant: BASF AG
Inventor: STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JUERGEN , GARCIA-LADONA FRANCISCO X , EMLING FRANZ
IPC: A61K31/435 , A61P25/24 , C07D495/14
Abstract: The invention relates to new 3-substituted 3,4,5,7-tetrahydropyrolo[3',4':4,5] thieno] pyrimidine derivatives with the formula where the substituents have the meanings listed in the description, to their preparation and application as medicamentous forms. 6 claims
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公开(公告)号:SK1052000A3
公开(公告)日:2000-08-14
申请号:SK1052000
申请日:1998-07-23
Applicant: BASF AG
Inventor: STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JUERGEN , GARCIA-LADONA FRANCISCO JAVIER , EMLING FRANZ
IPC: A61K31/435 , A61P25/24 , C07D495/14 , A61K31/4353
Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.
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公开(公告)号:PL337454A1
公开(公告)日:2000-08-14
申请号:PL33745498
申请日:1998-05-29
Applicant: BASF AG
Inventor: STEINER GERD , HOLZENKAMP UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JUERGEN , GARCIA-LADONA FRANCISCO JAVIER , EMLING FRANZ
IPC: A61K31/505 , A61K31/519 , A61P25/00 , A61P25/24 , A61P43/00 , C07D495/14
Abstract: PCT No. PCT/EP98/03231 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56793 PCT Pub. Date Dec. 17, 19983-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I where R1 is a hydrogen atom, a C1-C4-alkyl group, an acetyl group, a phenylalkyl C1-C4 radical, the aromatic system being unsubstituted or substituted by halogen, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it also being possible for the linkage between Y and Z to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.
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