公开(公告)号：WO1995010758A2

公开(公告)日：1995-04-20

申请号：PCT/US1994010855

申请日：1994-09-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GESSWEIN, Douglas, H. ,  MILLS, Timothy, C. ,  KLUMB, Peter, B.

IPC: G01H03/00

CPC classification number: A61B17/22012 ,  A61B18/1206 ,  A61B46/10 ,  A61B2017/00106

Abstract: A device (10) for measuring ultrasonic activity in an ultrasound delivery system has a sensor (50) for providing an output representative of a sensed ultrasound vibration level, an indicator (14) for receiving the output of the sensor (50) and providing an indication of the vibration level sensed thereby, and a rigid body (16) to which the sensor is attached. The rigid body (16) comprises a sensor attaching portion and a catheter abutting portion (18) configured to abut the distal end of an ultrasound delivery system catheter (20). Ultrasonic activity of the ultrasound delivery system is measured by abutting the distal end of the catheter (20) to the catheter abutting portion (18) of the rigid body (16) and noting the indication provided by the indicator (14). Use of a disposable sterile catheter abutting portion (18) removably attachable to the sensor attaching portion facilitates isolation of the sensor attaching portion within a bag along with an ultrasound transducer.

Abstract translation: 一种用于在超声输送系统中测量超声波活动的装置（10）具有传感器（50），用于提供表示感测到的超声波振动水平的输出;指示器（14），用于接收传感器（50）的输出并提供一个 由此感测到的振动水平的指示，以及附接有传感器的刚体（16）。 刚体（16）包括传感器附接部分和导管邻接部分（18），其构造成邻接超声输送系统导管（20）的远端。 通过将导管（20）的远端邻接到刚体（16）的导管邻接部分（18）并注意由指示器（14）提供的指示来测量超声输送系统的超声波活动。 使用可移除地附接到传感器附接部分的一次性无菌导管邻接部分（18）便于将传感器附接部分与超声换能器一起隔离在袋子内。

公开(公告)号：WO1995009027A1

公开(公告)日：1995-04-06

申请号：PCT/US1994010671

申请日：1994-09-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MUNSCH, John, M.

IPC: A61M39/26

CPC classification number: F16L37/33 ,  A61M39/26 ,  Y10S604/905

Abstract: A connector having an occluder which transposes between a first position and a second position is provided for maintaining a sterile environment during connection and disconnection of fluid communication between a container and a fluid line. The occluder is in the form of a spherical ball integrally formed with a length of tubing. The occluder has a diameter slightly larger than an end of the connector such that the occluder rolls into the end upon disconnecting from the system. An interface may be provided to receive a single connector or a pair of connectors to assist in fluid control between the container and the fluid line.

Abstract translation: 提供具有在第一位置和第二位置之间转置的封闭器的连接器，用于在容器和流体管线之间的流体连通的连接和断开期间维持无菌环境。 封堵器是与一段管道整体形成的球形球形。 封堵器具有比连接器的端部略大的直径，使得当与系统断开连接时封堵器滚动到最后端。 可以提供接口以接收单个连接器或一对连接器以辅助容器和流体管线之间的流体控制。

公开(公告)号：WO1995003332A1

公开(公告)日：1995-02-02

申请号：PCT/US1994007511

申请日：1994-07-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CURTIS, Joseph, Edward ,  HELGERSON, Sam, Leland

IPC: C07K14/755

CPC classification number: C07K14/755 ,  A61K38/00

Abstract: A method for preparing a purified and stable activated human Factor VIII composition is disclosed. A purified and stable activated human Factor VIII composition having a specific activity of at least 100,000 units per mg protein, or a potency of at least 15,000 units per ml is also disclosed.

Abstract translation: 公开了制备纯化和稳定的活化人因子VIII组合物的方法。 还公开了具有至少100,000单位/ mg蛋白质的比活性或每毫升至少15,000单位的效能的纯化和稳定的活化人因子VIII组合物。

公开(公告)号：WO1995003112A1

公开(公告)日：1995-02-02

申请号：PCT/US1994001905

申请日：1994-02-14

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BROWN, Richard, I.

IPC: B01D37/00

CPC classification number: B04B13/00 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/08 ,  B01D2221/10 ,  B04B5/0442 ,  A61M2202/0071

Abstract: Systems and methods for collecting cellular-rich concentrates of blood are disclosed. Blood from donor (78) is mixed with anticoagulant (90) and conveyed to a first separation device (12) for separating an anticoagulated cellular suspension from blood. The anticoagulated cellular suspension is conveyed to a second separation device (14) for removing leukocytes. Leukocyte-depleted cellular suspension is conveyed to a third separation device (16) for concentrating the leukocyte-depleted cellular suspension into a cellular-rich concentrate and a cellular-poor component and a portion of the cellular-poor component is returned to the donor (78). A controller (88) is used to control the process including monitoring the rate at which anticoagulant carried in the cellular-poor component is being infused with the returned cellular-poor component into the donor (78).

Abstract translation: 公开了收集富含细胞的血液浓缩物的系统和方法。 来自供体（78）的血液与抗凝血剂（90）混合并输送到第一分离装置（12）以将抗凝细胞悬浮液与血液分离。 将抗凝细胞悬浮液输送到用于去除白细胞的第二分离装置（14）。 将白细胞贫乏的细胞悬浮液输送到第三分离装置（16），用于将白细胞贫乏的细胞悬浮液浓缩成富含细胞的浓缩物和贫乏细胞的组分，并将一部分贫细胞组分返回给供体（ 78）。 控制器（88）用于控制该过程，包括监测在将细胞贫乏成分中携带的抗凝血剂与所返回的细胞贫乏成分注入供体（78）中的速率。

公开(公告)号：WO1995003108A1

公开(公告)日：1995-02-02

申请号：PCT/US1994001907

申请日：1994-02-14

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BROWN, Richard, I.

IPC: B01D21/26

CPC classification number: B04B5/0442 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B01D21/262 ,  B01D21/302 ,  B01D2221/08 ,  B01D2221/10 ,  B04B2005/045 ,  A61M2202/0071

Abstract: Systems and methods for resuspending cellular-rich concentrates of blood are disclosed. Systems include first compartment (24) including a blood inlet port (40) and a plasma-rich platelets (PRP) collection port (38) and a red blood cell collection port (42), and second compartment (26) including a platelet-poor plasma (PPP) collection port (44) and a leukocyte-depleted PRP (LDPRP) inlet port (46), and a separation element (14). In resuspension mode, a volume of retained PPP is returned through the PPP collection port (44) into the second compartment (26) to mix with and resuspend leukocyte-depleted platelet concentrate (LDPC) in the second compartment (26). During the resuspension period, a rotor (28) slowly oscillates the second compartment (26) first in one rotational direction and then in an opposite rotational direction. The oscillation creates variable agitation forces that aid the mixing and resuspension process within the second compartment (26).

Abstract translation: 公开了用于重悬细胞富集的血液浓缩物的系统和方法。 系统包括包括血液入口（40）和富血小板血浆（PRP）收集口（38）和红细胞收集口（42）的第一隔室（24），以及包括血小板 - 贫血血浆（PPP）收集口（44）和白细胞贫乏的PRP（LDPRP）入口（46）和分离元件（14）。 在再悬浮模式中，通过PPP收集端口（44）将一定量的保留的PPP返回到第二隔室（26），以将第二隔室（26）中的白细胞贫乏的血小板浓缩物（LDPC）混合并重新悬浮。 在再悬浮期间，转子（28）首先在一个旋转方向上然后以相反的旋转方向缓慢振荡第二隔室（26）。 振荡产生可变搅拌力，其有助于在第二隔室（26）内的混合和再悬浮过程。

公开(公告)号：WO1995001196A1

公开(公告)日：1995-01-12

申请号：PCT/US1994003857

申请日：1994-04-08

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GORMAN, Brian, J. ,  NORDQUIST, Jeffrey, S.

IPC: A61M05/24

CPC classification number: A61M5/1409

Abstract: A cannula structure (40, 100), comprising a cannula (42, 94, 102) having a tubular member (70, 92, 110) secured thereon in surrounding relationship by the exertion of sufficient force by an interior wall of the tubular member on the cannula such that at least one fluid flow path is provided between an exterior wall of the cannula and the interior wall of the tubular member. Preferably, the tubular member is squeezed on opposite sides of the cannula so as to secure the tubular member onto the cannula by crimping.

Abstract translation: 一种套管结构（40,100），其包括套管（42,94,102），所述套管具有管状构件（70,92,110），所述管状构件（70,92,110）通过所述管状构件的内壁施加足够的力而以环绕关系固定在其上 套管使得至少一个流体流动路径设置在套管的外壁和管状构件的内壁之间。 优选地，管状构件在套管的相对侧被挤压，以便通过卷曲将管状构件固定到套管上。

公开(公告)号：WO1995001192A2

公开(公告)日：1995-01-12

申请号：PCT/US1994007257

申请日：1994-06-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  COOK, Charles ,  ZOMORODI, Mostafa ,  DARK, Richard, C., G.

IPC: A61M01/00

CPC classification number: A61M1/0001 ,  A61M1/0011 ,  A61M1/0017 ,  A61M1/005 ,  A61M1/0096 ,  A61M39/06 ,  A61M39/10

Abstract: A patient fluid collection system is disclosed which includes a fluid collection reservoir (48), a cover (62) for the reservoir and a liner (60) within the reservoir comprising an enlargeable or expandable wall portion such that the wall portion (64) may expand if the liner fills with fluid. An anti-reflux system is also disclosed as well as a new tandem tube and a new connector.

Abstract translation: 公开了一种患者流体收集系统，其包括流体收集容器（48），用于储存器的盖（62）和储存器内的衬垫（60），其包括可扩大或可扩张的壁部分，使得壁部分（64）可以 如果衬管充满流体，则膨胀。 还公开了一种防回流系统，以及一种新的串联管和一个新的连接器。

公开(公告)号：WO1995000186A1

公开(公告)日：1995-01-05

申请号：PCT/US1994007305

申请日：1994-06-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  RAIBLE, Donald, A.

IPC: A61M01/10

CPC classification number: F04D29/2277 ,  A61M1/10 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1013 ,  A61M1/1029 ,  A61M1/1034 ,  A61M1/1036 ,  F05B2260/604 ,  Y10S415/90

Abstract: A dynamic blood pump (10) includes a rotating core member (70) and rotating ring portion (76) effective to pre-spin blood before the blood enters helical pumping channels (96) of the pump. The blood is pumped and further rotated as it moves axially along the helical channels (96) toward a centrifugal section of the pump (40). At the centrifugal pumping section circumferential velocity differentials are also controlled to diminish damage to the blood. Outwardly of the centrifugal pumping section, a forced-vortex pumping section communicates the pumped blood to an exit port.

Abstract translation: 动态血液泵（10）包括旋转的芯构件（70）和旋转环部分（76），其有效地在血液进入泵的螺旋泵送通道（96）之前预先旋转血液。 当血液被泵送并进一步沿着螺旋通道（96）朝向泵（40）的离心部分轴向移动时旋转。 在离心泵送部分，圆周速度差也被控制以减少对血液的损伤。 在离心泵送部分的外部，强迫涡流泵送部分将泵送的血液连通到出口。

公开(公告)号：WO1994024272A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004083

申请日：1994-04-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  LEE, Catherine ,  HORNACEK, Cynthia ,  DINH, Tan, Thanh

IPC: C12N09/52

CPC classification number: C12N9/52 ,  Y10S435/815 ,  Y10S435/842

Abstract: A process for purifying crude collagenase is disclosed. The collagenase purification process includes providing a stabilized crude collagenase solution containing collagenase, pigment, toxins, bacterial materials, and proteolytic enzyme impurities including clostripain, trypsin, and caseinase. The stabilized collagenase solution is applied to hydroxylapatite packing. Pigment and caseinase are eluted with a first solution comprising about 0.05 M to about 0.3 M phosphate buffer, and then collagenase, trypsine, and clostripain are eluted with a second solution comprising about 0.35 M to about 0.5 M phosphate buffer to provide a first collected solution. The first collected solution is then applied to gel filtration packing and collagenase and clostripain are eluted with a neutral pH buffer solution, to provide a second collected solution. The second collected solution is then applied to Reactive Red 120-Agarose packing and collagenase is eluted with a neutral pH buffer solution to provide purified collagenase. The process provides extremely pure collagenase in high yield with reduced consumption of eluting solutions and avoids unpredictable gradient eluting techniques.

Abstract translation: 公开了一种纯化粗胶原酶的方法。 胶原酶纯化方法包括提供包含胶原酶，颜料，毒素，细菌材料和蛋白水解酶杂质的稳定的粗胶原酶溶液，包括clostripain，胰蛋白酶和酪蛋白酶。 将稳定的胶原酶溶液应用于羟基磷灰石包装。 用包含约0.05M至约0.3M磷酸盐缓冲液的第一溶液洗脱颜料和酪蛋白酶，然后用包含约0.35M至约0.5M磷酸盐缓冲液的第二溶液洗脱胶原酶，胰蛋白酶和梭菌素，以提供第一收集溶液 。 然后将第一次收集的溶液施加到凝胶过滤填充物上，并用中性pH缓冲溶液洗脱胶原酶和clostripain，以提供第二个收集的溶液。 然后将第二次收集的溶液应用于活性红120-琼脂糖包装，并用中性pH缓冲溶液洗脱胶原酶以提供纯化的胶原酶。 该方法以高产率提供极纯的胶原酶，减少洗脱溶液的消耗并避免不可预测的梯度洗脱技术。

公开(公告)号：WO1994020603A1

公开(公告)日：1994-09-15

申请号：PCT/US1994002126

申请日：1994-02-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  OFSTHUN, Norma, J. ,  HENDERSON, Lee, W. ,  BROWN, Richard, I. ,  PAULEY, Robin, G.

IPC: C12M03/06

CPC classification number: B01D61/243 ,  B01D61/14 ,  B01D69/02 ,  B01D69/08 ,  C12M29/16

Abstract: The invention provides dual-skinned membrane useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200,000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.

Abstract translation: 本发明提供双皮肤膜，其可用作单向或整流膜，其减少透析中溶质分子的反过滤，并改善膜生物反应器中的营养供应和产物回收。 膜是双面聚合材料，优选为中空纤维的形式。 膜在相对侧具有聚合物的表面，对溶质和筛分系数特性具有不同的渗透性。 每侧的皮肤具有在10,000倍放大率下不可见的孔，所述表皮之间的微孔结构包含能够在内部和外部皮肤之间以更高浓度保持在约5000至200,000的分子量范围内的溶质的孔。 通过使用中空纤维膜束作为具有整流性质的透析装置形成改进的透析装置。