公开(公告)号：GR3030365T3

公开(公告)日：1999-09-30

申请号：GR990401456

申请日：1999-05-28

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/18 ,  A61K31/27 ,  A61K31/275 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C229/00 ,  C07C277/08 ,  C07C279/22 ,  C07C317/46 ,  C07C323/44 ,  C07C323/60 ,  C07C323/63

Abstract: Benzoyl guanine derivs. of formula(I) and their salts are new. One of the substits. R1-R3 = Y-Ph-Ä(CH2)k-CHR7-CO-R8Ü; and the others = 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, SO2NHC(=Y')NR18R19, H, halo, CN, Z(CH2)p-CqF2q+1, SOuR22, CONR23R24, COR25, SO2NR26R27, OR35 or NR35R36; Ph = phenylene (opt. mono- or di-substd. by Fl, Cl, CF3, Me, OH, OMe or NR37R38); R37, R38 = H or Me; Y = a bond, O, S or NR9; R9 = H or 1-4C alkyl; R7 = OR10 or NR10R11; R10 = H 1-8C alkyl, 1-8C alkanoyl, 1-8C alkoxycarbonyl, benzyl, or benzyloxycarbonyl; R11 = as R10 or trityl; R8 = OR12 or NR12R13; R12, R13 = H, 1-8C alkyl or benzyl; R14 = 3-8C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe, or NR15R16); R15, R16 = H or Me; Y' = O, S or NR20; R18, R19 = H, 1-8C alkyl, 3-6C alkenyl or (CH2)tR21; or R18+R19 = A; R21 = 5-7C cycloalkyl or phenyl, (both opt. mono- to tri-substd. by F, Cl, OMe or 1-4C alkyl); R20 = as R18 or amidine; Z = a bond, O, S or NR28; R22 = 1-8C alkyl, 3-6C alkenyl, (CH2)nR29 or CF3; R23, R25, R26 = as R22 or H; R24, R27 = H or 1-4C alkyl; or R23+R24, R26+R27 = A; A = (CH2)4 or (CH2)5 (both opt. having a CH2 replaced by O, S, NH, NMe or N-benzyl; R28 = H or 1-3C alkyl; R29 = 3-7C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = (CH2)y (opt. having a CH2 gp. replaced by O, S, NH, NMe or N-benzyl); R4, R5 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CrF2r+1; R32-R34 = H or 1-3C alkyl; k, n, t = 0-4; m, u, p = 0-2; q = 1-6; r = 1-4; and y = 4-7.

公开(公告)号：AT183179T

公开(公告)日：1999-08-15

申请号：AT95106596

申请日：1995-05-02

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/47 ,  A61K31/472 ,  A61P3/08 ,  A61P3/10 ,  A61P9/06 ,  A61P9/10 ,  A61P13/08 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22 ,  C07D215/00 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D217/00 ,  C07D217/02 ,  C07D217/26

Abstract: New bicyclic heteroaryl-carboxy-guanidine cpds. and their salts have two fused 6-membered rings contg. up to 4 unsubstd. ring N atoms. The other ring members are C atoms, opt. substd. e.g. by halo, alkyl, alkoxy, alkenyl, alkynyl, amino, carboxyguanidine, cyano, alkylthio, acyl, carboxamido, perfluoroalkyl, (poly)hydroxyalkyl, alkanoylalkyl, aminosulphonyl, (thio)ureidosulphonyl, heteroaryl, phenoxy, phenylthio or phenylamino, where the phenyl rings are opt. substd. by heterocyclyl, (poly)hydroxyalkyl or (poly)hydroxyalkylcarbonyl; or two substits. together form a satd. gp. that completes a fused ring.

公开(公告)号：AT178315T

公开(公告)日：1999-04-15

申请号：AT95113847

申请日：1995-09-04

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/18 ,  A61K31/27 ,  A61K31/275 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C229/00 ,  C07C277/08 ,  C07C279/22 ,  C07C317/46 ,  C07C323/44 ,  C07C323/60 ,  C07C323/63

Abstract: Benzoyl guanine derivs. of formula(I) and their salts are new. One of the substits. R1-R3 = Y-Ph-Ä(CH2)k-CHR7-CO-R8Ü; and the others = 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, SO2NHC(=Y')NR18R19, H, halo, CN, Z(CH2)p-CqF2q+1, SOuR22, CONR23R24, COR25, SO2NR26R27, OR35 or NR35R36; Ph = phenylene (opt. mono- or di-substd. by Fl, Cl, CF3, Me, OH, OMe or NR37R38); R37, R38 = H or Me; Y = a bond, O, S or NR9; R9 = H or 1-4C alkyl; R7 = OR10 or NR10R11; R10 = H 1-8C alkyl, 1-8C alkanoyl, 1-8C alkoxycarbonyl, benzyl, or benzyloxycarbonyl; R11 = as R10 or trityl; R8 = OR12 or NR12R13; R12, R13 = H, 1-8C alkyl or benzyl; R14 = 3-8C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe, or NR15R16); R15, R16 = H or Me; Y' = O, S or NR20; R18, R19 = H, 1-8C alkyl, 3-6C alkenyl or (CH2)tR21; or R18+R19 = A; R21 = 5-7C cycloalkyl or phenyl, (both opt. mono- to tri-substd. by F, Cl, OMe or 1-4C alkyl); R20 = as R18 or amidine; Z = a bond, O, S or NR28; R22 = 1-8C alkyl, 3-6C alkenyl, (CH2)nR29 or CF3; R23, R25, R26 = as R22 or H; R24, R27 = H or 1-4C alkyl; or R23+R24, R26+R27 = A; A = (CH2)4 or (CH2)5 (both opt. having a CH2 replaced by O, S, NH, NMe or N-benzyl; R28 = H or 1-3C alkyl; R29 = 3-7C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = (CH2)y (opt. having a CH2 gp. replaced by O, S, NH, NMe or N-benzyl); R4, R5 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CrF2r+1; R32-R34 = H or 1-3C alkyl; k, n, t = 0-4; m, u, p = 0-2; q = 1-6; r = 1-4; and y = 4-7.

公开(公告)号：DK0638548T3

公开(公告)日：1998-11-23

申请号：DK94112383

申请日：1994-08-08

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  LANG HANS-JOCHEN DR ,  KLEEMANN HEINZ-WERNER DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/155 ,  A61K31/17 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/22 ,  C07C327/48 ,  C07C335/16 ,  C07C335/22 ,  C07D295/195 ,  C07D295/20 ,  C07D295/215

公开(公告)号：DE19713427A1

公开(公告)日：1998-10-08

申请号：DE19713427

申请日：1997-04-01

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/155 ,  A61K31/165 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22 ,  C07C277/08 ,  A01N1/00

Abstract: Benzoyl-guanidines of formula (I) and their salts are new. One of R2,R3 = H; and the other = -C(OH)MeCH2OH, -CHMeCH2OH or -C(OH)(Me)2; and R4 = Me, OMe, Cl or CF3 (preferably Me).

公开(公告)号：DE19702045A1

公开(公告)日：1998-07-23

申请号：DE19702045

申请日：1997-01-22

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  FABER SABINE DR ,  JANSEN HANS-WILLI DR

IPC: A01N1/02 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  A61K31/41 ,  C07D403/04 ,  C07D403/14

Abstract: 1-Benzylimidazole derivatives of formula (I) and their salts are new. R1 = H, 1-8C alkyl, -CaH2a-Ar or -CaH2a-(3-7C)cycloalkyl; a = 0-2; Ar = phenyl or 1-9C heteroaryl (both optionally substituted by 1-3 F, Cl, Br, I, CF3, Me, OMe, OH or NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, F, Cl, Br, I, CF3, CN, NO2, CH2OR17, COR6 or OR7, 1-8C alkyl, 3-7C cycloalkyl, -CaH2a-Ar or -SOa-R22; R17= H or 1-8C alkyl; R6 = H, 1-8C alkyl, OR30 or phenyl (optionally substituted as in Ar); R7 = H, 1-8C alkyl or Ar; R22 = 1-8C alkyl, 3-7C cycloalkyl or -CaH2a-Ph; R4, R5 = H, 1-8C alkyl, F, Cl, Br, I, CF3, CN, NO2, SOa-R16, COR23 or OR24; R16 = 1-8C alkyl or phenyl (optionally substituted as in Ar); R23 = H, 1-8C alkyl or OR25; R24 = H, 1-8C alkyl or phenyl (optionally substituted as in Ar); and R25 = H or 1-8C alkyl. Also claimed is the treatment or prophylaxis of ischaemia-mediated conditions or the treatment of respiratory disorders using a tetrazole derivative.

公开(公告)号：ES2114874T3

公开(公告)日：1998-06-16

申请号：ES91122406

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR ,  BECKER REINHARD DR

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：DE59405764D1

公开(公告)日：1998-05-28

申请号：DE59405764

申请日：1994-08-08

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  LANG HANS-JOCHEN DR ,  KLEEMANN HEINZ-WERNER DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/155 ,  A61K31/17 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/22 ,  C07C327/48 ,  C07C335/16 ,  C07C335/22 ,  C07D295/195 ,  C07D295/20 ,  C07D295/215

公开(公告)号：CZ9700271A3

公开(公告)日：1998-05-13

申请号：CZ27197

申请日：1997-01-29

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  BRENDEL JOACHIM DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS JOCHEN DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/17 ,  A61K31/18 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C279/22 ,  C07C311/21 ,  C07C311/60

CPC classification number: C07C311/21 ,  C07C279/22 ,  C07C311/60

公开(公告)号：CZ65397A3

公开(公告)日：1998-05-13

申请号：CZ65397

申请日：1997-03-03

Applicant: HOECHST AG

Inventor： ALBUS UDO DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHOLZ WOLFGANG DR ,  SCHWAFK JAN ROBERT DR ,  WEICHERT ANDREAS DR

IPC: A61K31/165 ,  A01N1/02 ,  A61K31/155 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22

Abstract: 2-Alkoxy-benzoylguanidines of formula (I) and their salts are new. R1-R3 = H, F, Cl, Br, I, CN, NO2, 1-8C alkyl, 1-8C alkoxy, 3-8C cycloalkyl, 3-8C cycloalkoxy, Xa-(CH2)b-(CF2)c-CF3, SR10, OR10, CR10R11R12, Ar, SR13, OR13, NHR13, NR13R14, CHR13R15, C(R15)(R16)OH, CCR18, CR19=CHR18 or (CR20R21)k-CO-(CR22R23)l-R24; R4 = 1-4C alkyl; Ar = phenyl, naphthyl, biphenylyl, or 1-9C heteroaryl (bonded via C or N) all optionally mono- to - tri-substituted by Z; Z = F, Cl, CF3, CH3, methoxy, OH, NH2, NHCH3, NH(CH3)2; X = O, S or NR5; R5 = H, 1-4C alkyl or CdH2d-R6; R6 = phenyl, biphenylyl, naphthyl (all optionally mono- to tri-substituted by Z') or 3-8C cycloalkyl; Z' = F, Cl, CF3, methyl, methoxy, or NR7R8; R7, R8 = H or 1-4C alkyl; R10 = CfH2f-3-8C cycloalkyl or phenyl (optionally mono- to tri-substituted by Z); R11, R12 = as R10, H, or 1-4C alkyl; R13, R14 = (CH2)g-(CHOH)h-(CH2)i-(CHOH)j-R17, (CH2)g-O-(CH2CH2O)h-R24; R15, R16 = H or 1-6C alkyl; or CR15R16 = 3-8C cycloalkyl; R17 = H or CH3; R18 = phenyl, 1-9C heteroaryl (optionally mono- to tri-substituted by Z'), 1-6C alkyl (optionally mono- to tri-substituted by OH) or 3-8C cycloalkyl; R19 - R23 = H or CH3; R24 = H, 1-6C alkyl, 3-8C cycloalkyl or CmH2m-R18; a = 0 or 1; b, f = 0-2; c =0-3; d, g, h, i, k, l = 0-4; j, m = 1-4;