公开(公告)号：WO1996010832A1

公开(公告)日：1996-04-11

申请号：PCT/US1995013007

申请日：1995-09-28

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  TRUMPER, David, L. ,  KIM, Won-jong ,  WILLIAMS, Mark, E.

IPC: H01F07/02

CPC classification number: G03F7/70758 ,  H01F7/20

Abstract: The invention provides electromagnet arrays (28) which can provide selected field patterns in either two or three dimensions, and in particular, which can provide single-sided field patterns in two or three dimensions. These features are achieved by providing arrays which have current densities that vary in the windings both parallel to the array and in the direction of array thickness.

Abstract translation: 本发明提供电磁体阵列（28），其可以提供二维或三维的所选择的场图案，特别地，其可以提供两维或三维的单面场图案。 这些特征通过提供具有在平行于阵列的线圈和阵列厚度的方向上变化的电流密度的阵列来实现。

公开(公告)号：WO1995034811A1

公开(公告)日：1995-12-21

申请号：PCT/US1994006575

申请日：1994-06-10

Applicant: OCULON CORPORATION ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： OCULON CORPORATION ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  BENEDEK, George, B. ,  THURSTON, George, M. ,  CLARK, John, I.

IPC: G01N33/48

CPC classification number: A61K31/00 ,  A61K31/16 ,  G01N33/48

Abstract: There are disclosed protein condensation inhibitors which are useful in the treatment of phase transition disease states associated with the phase transition of proteins from a soluble to a condensed state. Methods of identifying compounds for their ability to function as protein condensation inhibitors, as well as the use of such protein condensation inhibitors to treat phase transition disease states, are also disclosed. In one embodiment, a method of identifying compounds comprises assaying the compound in an aqueous protein solution to determine whether the sign of delta E is positive. In this method, the assaying may include the steps of measuring a change in phase separation temperature and determining whether protein condensation occurs upon raising or lowering the temperature of the aqueous protein solution. Preferably, the aqueous protein solution comprises a protein associated with a phase transition disease state, such as sickle hemoglobin. In another embodiment, a method of identifying compounds involves assaying the compound in at least two distinct aqueous protein solutions for its ability to prevent or delay a temperature dependent phase transition to a condensed state in each of the distinct aqueous protein solutions. Examples of suitable proteins for the distinct aqueous protein solutions include lysozyme and sickle hemoglobin.

Abstract translation: 公开了可用于治疗与从可溶性到冷凝状态的蛋白质相变相关的相变疾病状态的蛋白质缩合抑制剂。 还公开了鉴定化合物作为蛋白质缩合抑制剂的能力的方法，以及使用这种蛋白质缩合抑制剂来治疗相变疾病状态。 在一个实施方案中，鉴定化合物的方法包括测定蛋白质水溶液中的化合物以确定δE的符号是否为阳性。 在该方法中，测定可以包括以下步骤：测量相分离温度的变化并确定在蛋白质水溶液升高或降低温度时是否发生蛋白质冷凝。 优选地，蛋白质水溶液包含与相变疾病状态相关的蛋白质，例如镰刀血红蛋白。 在另一个实施方案中，鉴定化合物的方法包括在至少两种不同的蛋白质水溶液中测定化合物的能力，以防止或延迟每种不同含水蛋白质溶液中的温度依赖性相转变为冷凝状态。 用于不同含水蛋白质溶液的合适蛋白质的实例包括溶菌酶和镰状血红蛋白。

公开(公告)号：WO1995033971A1

公开(公告)日：1995-12-14

申请号：PCT/US1995006075

申请日：1995-05-16

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SWANSON, Eric, A.

IPC: G01B09/02

CPC classification number: A61B5/0066 ,  A61B1/00183 ,  A61B3/1005 ,  A61B3/102 ,  A61B3/1225 ,  A61B5/0068 ,  A61B5/441 ,  A61B5/6852 ,  A61B2562/0242 ,  G01B9/02002 ,  G01B9/02019 ,  G01B9/02027 ,  G01B9/02091 ,  G01B11/00 ,  G01B11/2441 ,  G01B2290/35 ,  G01B2290/45 ,  G01J1/00 ,  G01J9/02 ,  G01N21/4795 ,  G02B5/1828 ,  G11B2007/0013 ,  H01S5/141

Abstract: An apparatus and method for acquiring an at least one dimensional digital image of a region of an object (28) using an optical source (12) which outputs a first optical beam having a short coherence length. A splitter (22) splits the first optical beam into a reference beam (30) and an object beam (40). The reference beam travels to a reference scatterer (32) and the object beam (26) is directed toward the region of the object. An array detector (54) such as a charge coupled device receives a portion of the object beam (18a') and a portion of the reference beam (18b') and detects the resulting incident intensity over the at least one dimension and outputs a signal (823). Since the coherence length of the source is short, the signal output from the detector array corresponds to one or more dimensional slice of the object which represents the above region.

Abstract translation: 一种用于使用输出具有短相干长度的第一光束的光源（12）来获取对象（28）的区域的至少一维数字图像的装置和方法。 分离器（22）将第一光束分成参考光束（30）和物体光束（40）。 参考光束行进到参考散射体（32），物体光束（26）指向物体的区域。 诸如电荷耦合器件的阵列检测器（54）接收目标光束（18a'）的一部分和参考光束（18b'）的一部分，并且在至少一维上检测所得到的入射强度，并输出信号 （823）。 由于源的相干长度短，从检测器阵列输出的信号对应于表示上述区域的物体的一个或多个维度切片。

公开(公告)号：WO1995026049A1

公开(公告)日：1995-09-28

申请号：PCT/US1995003539

申请日：1995-03-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  COHEN, Simon, S.

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

IPC: H01L23/525

CPC classification number: H01L23/5256 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/3011 ,  Y10S148/055 ,  H01L2924/00

Abstract: A device and a method for interrupting the continuity of a conductor and linking a pair of conductors are disclosed. The device is a three-terminal fuse having first and second terminals initially connected by a conductor and a third terminal separated from the conductor at a breakpoint of the conductor by an insulator. By applying a voltage across the third terminal or control terminal and the conductor, a transient conductive link is formed between the conductor and the control terminal. If sufficient current is provided through the transient link, heating of the link causes the metal of the conductor to melt and boil away, thus interrupting the continuity of the conductor.

Abstract translation: 公开了一种用于中断导体的连续性并连接一对导体的装置和方法。 该器件是三端保险丝，其具有由导体初始连接的第一和第二端子，以及在绝缘体的导体的断点处与导体分离的第三端子。 通过在第三端子或控制端子和导体上施加电压，在导体和控制端子之间形成瞬态导电连接。 如果通过瞬态连接提供足够的电流，则连接件的加热会导致导体的金属熔化和沸腾，从而中断导体的连续性。

公开(公告)号：WO1995024734A1

公开(公告)日：1995-09-14

申请号：PCT/US1995003107

申请日：1995-03-09

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  BERNSTEIN, Joseph, B.

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

IPC: H01L23/525

CPC classification number: H01L23/5254 ,  H01L2924/0002 ,  H05K1/0286 ,  H05K3/4038 ,  H01L2924/00

Abstract: Conductive links are provided between conductive materials, e.g., metals, separated by a non-conductive material, e.g., a silicon-based glass material. In a preferred embodiment, a single pulse of laser energy is applied to at least one of the conductive materials to produce mechanical strain therein which strain initiates a fracturing of the non-conductive material so as to provide at least one fissure therein extending between the conductive materials. The laser energy pulse further causes at least one of the conductive materials to flow in such fissure to provide a conductive link between the conductive materials. Preferably, the non-conductive material is formed in layers such that an interface between the layers controls the fissures.

Abstract translation: 在导电材料（例如金属）之间提供导电连接，金属由非导电材料例如硅基玻璃材料隔开。 在优选实施例中，将激光能量的单个脉冲施加到至少一个导电材料以在其中产生机械应变，其中该应变引起非导电材料的断裂，从而在导电材料之间提供至少一个裂缝 材料。 激光能量脉冲进一步导致至少一种导电材料在这种裂缝中流动以在导电材料之间提供导电连接。 优选地，非导电材料形成为层，使得层之间的界面控制裂缝。

公开(公告)号：WO1995022773A1

公开(公告)日：1995-08-24

申请号：PCT/US1995002141

申请日：1995-02-21

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FARN, Michael ,  VELDKAMP, Wilfrid, B.

IPC: G02B05/18

CPC classification number: G02B27/1013 ,  G02B5/1871 ,  G02B5/1876 ,  G02B5/1885 ,  G02B5/203 ,  G02B27/1086 ,  G02B27/123 ,  G02F1/133621 ,  G02F2001/133623

Abstract: Optical apparatus for dispensing a visible light spectrum into primary color bands and directing each color band into a specific pixelated cell of a passive display. The apparatus includes an array of refractive microlenses arranged parallel to the plane of the passive display such as a liquid crystal display and a diffraction grating arranged parallel and in close proximity to the lens array. The microlenses focus visible light onto the display while the diffraction grating separates the visible light into primary color bands in different diffraction orders such that the colors are directed to and transmitted through the corresponding specific pixelated cells.

Abstract translation: 用于将可见光谱分配到原色带中并将每个色带引导到被动显示器的特定像素化单元中的光学装置。 该装置包括平行于无源显示器的平面布置的折射微透镜阵列，例如液晶显示器和平行并且靠近透镜阵列布置的衍射光栅。 微透镜将可见光聚焦到显示器上，而衍射光栅将可见光分成不同衍射级的主色带，使得颜色被引导并通过相应的特定像素化单元传输。

公开(公告)号：WO1995015919A1

公开(公告)日：1995-06-15

申请号：PCT/US1994012564

申请日：1994-11-01

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CORNIE, James, A.

IPC: C01B31/00

CPC classification number: C04B35/63496 ,  B22C1/00 ,  B22C1/22 ,  B22C9/02 ,  B22F3/1283 ,  B22F2998/00 ,  C04B35/013 ,  C04B35/524 ,  C04B35/532 ,  C04B35/634 ,  C04B35/63444 ,  C04B35/63476 ,  C04B35/63488 ,  C22C47/06 ,  C22C47/064 ,  C22C47/068

Abstract: The invention provides methods for producing semi-permanent casting tooling, as well as semi-permanent casting tooling apparatus. Casting tooling including a blend of high char resin and refractory powder; casting tooling prepared from a blend of sol-gel ceramic precursor and refractory powder; and a preform including a leachable core as well as methods for their production are provided. The casting tooling of the invention can be used in casting processes including die casting, permanent mold casting and pressure infiltration casting. Also provided is an investment mold casting technique compatible with a pressure infiltration process.

Abstract translation: 本发明提供半永久性铸造工具的制造方法以及半永久性铸造工具装置。 铸造工具，包括高焦炭树脂和耐火材料粉末的混合物; 由溶胶 - 凝胶陶瓷前体和难熔粉末的混合物制备的铸造工具; 并且提供了包括可浸出的芯的预成型件及其制造方法。 本发明的铸造工具可用于铸造，铸模，永久模铸和压力渗透铸造等铸造工艺。 还提供了与压力渗透过程相容的投资模具铸造技术。

公开(公告)号：WO1995008416A1

公开(公告)日：1995-03-30

申请号：PCT/US1994010404

申请日：1994-09-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  WALCZYK, Daniel

IPC: B23P15/24

CPC classification number: G05B19/4099 ,  B21D37/20 ,  B23P15/246 ,  B29C31/08 ,  B29C33/302 ,  B29C33/3842 ,  B29C64/141 ,  B29C2033/385 ,  G05B2219/45204 ,  G05B2219/49011 ,  G05B2219/49012 ,  G05B2219/49014 ,  G05B2219/49024 ,  G05B2219/49033 ,  Y10T83/205 ,  Y10T83/364 ,  Y10T83/6572

Abstract: A process of forming a profiled edge lamination die is disclosed. An apparatus for use in the process and the die produced thereby are also disclosed.

Abstract translation: 公开了一种形成成型边缘层压模的工艺。 还公开了一种用于该方法的装置和由此制造的模具。

公开(公告)号：WO1995008159A1

公开(公告)日：1995-03-23

申请号：PCT/US1994010527

申请日：1994-09-16

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  MENON, Murali, M. ,  BOUDREAU, Eric, R.

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

IPC: G06K09/62

CPC classification number: G06K9/6222 ,  G06K9/6276

Abstract: A pattern recognition system is described. During training, multiple training input patterns from multiple classes of subjects are grouped into clusters within categories by computing correlations between the training patterns and present category definitions. After training, each category is labeled in accordance with the peak class of patterns received within the cluster of the category. If the domination of the peak class over the other classes in the category exceeds a preset threshold, then the peak class defines the category. If the contrast does not exceed the threshold, then the category is defined as unknown. The class statistics for each category are stored in the form of a training class histogram for the category. During testing, frames of test data are received from a subject and are correlated with the category definitions. Each frame is associated with the training class histogram for the closest correlated category. For multiple-frame processing, the histograms are combined into a single observation class histogram which identifies the subject with its peak class within a predefined degree of confidence. In a multiple-channel configuration, the training patterns and testing patterns are divided into multiple features.

Abstract translation: 描述了模式识别系统。 在训练期间，通过计算训练模式与当前类别定义之间的相关性，将多类科目的多种训练输入模式分组到分类内。 经过培训，每个类别都按照类别集群内收到的模式的最高等级标注。 如果峰值类别与类别中其他类别的统治超过预设阈值，则峰值类定义该类别。 如果对比度不超过阈值，则该类别被定义为未知。 每个类别的类统计信息以类别的训练类直方图的形式存储。 在测试期间，从主题接收测试数据的帧，并与类别定义相关。 每个帧与最近相关类别的训练类直方图相关联。 对于多帧处理，将直方图组合成单个观察类直方图，其在预定义的置信度内以其峰值类别识别被摄体。 在多通道配置中，训练模式和测试模式分为多个特征。

公开(公告)号：WO1995005738A1

公开(公告)日：1995-03-02

申请号：PCT/US1994009439

申请日：1994-08-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  LOWE, Scott, W. ,  RULEY, H., Earl ,  JACKS, Tyler ,  HOUSMAN, David, E.

IPC: A01N43/38

CPC classification number: A01K67/0276 ,  A01K67/0271 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K48/00 ,  C07K14/005 ,  C07K14/4746 ,  C07K14/82 ,  C12N15/8509 ,  C12N2710/10322 ,  G01N33/5011

Abstract: A method for evaluating the ability of a treatment to adversely affect the growth or viability of a cell is described. A cell having reduced susceptibility to apoptosis is provided, a treatment is administered to this cell, and a determination is made as to whether the treament affects the value of a parameter related to the growth or viability of the cell. Also described are diagnostic and anticancer therapies. Cells and cell lines used in these methods are also provided.

Abstract translation: 描述了用于评估治疗对细胞的生长或活力的不利影响的能力的方法。 提供对细胞凋亡敏感性降低的细胞，向该细胞施用治疗，并且确定治疗剂是否影响与细胞的生长或活力相关的参数的值。 还描述了诊断和抗癌疗法。 还提供了用于这些方法的细胞和细胞系。