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公开(公告)号：AU2006271416A1
公开(公告)日：2007-01-25
申请号：AU2006271416
申请日：2006-07-17
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL
Abstract: The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.
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