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    MULTIVALENT ANTIBODIES
    1.
    发明申请
    MULTIVALENT ANTIBODIES 审中-公开
    多抗体

    公开(公告)号：WO2011061246A2

    公开(公告)日：2011-05-26

    申请号：PCT/EP2010067731

    申请日：2010-11-18

    Applicant: UCB PHARMA SA ,  HEYWOOD SAM PHILIP ,  HUMPHREYS DAVID PAUL ,  LAWSON ALASTAIR DAVID GRIFFITHS

    Inventor： HEYWOOD SAM PHILIP ,  HUMPHREYS DAVID PAUL ,  LAWSON ALASTAIR DAVID GRIFFITHS

    IPC: C07K16/00

    CPC classification number: C07K16/00 ,  C07K2317/35 ,  C07K2319/30 ,  C07K2319/31

    Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, and said fusion protein is conjugated to a PEG polymer.

    Abstract translation: 一种多价抗体融合蛋白，其包含：重链，其从N-末端开始依次包含可变结构域名义上的VH1，CH1区和另外的可变结构域名义上的VH2，轻链依次包含N-末端， 可变结构域名义上为VL1，CL结构域和名义上可变域为VL2，其中所述重链和轻链对齐以提供由VH1和VL1的第一可变结构域对形成的第一结合位点和由第二可变结构域形成的第二结合位点 VH2和VL2的可变结构域对，并且所述融合蛋白与PEG聚合物缀合。

    DISULFIDE STABILISED ANTIBODIES AND FRAGMENTS THEREOF
    2.
    发明申请
    DISULFIDE STABILISED ANTIBODIES AND FRAGMENTS THEREOF 审中-公开
    二硫化物稳定的抗体及其片段

    公开(公告)号：WO2011117648A3

    公开(公告)日：2011-11-17

    申请号：PCT/GB2011050608

    申请日：2011-03-25

    Applicant: UCB PHARMA SA ,  HUMPHREYS DAVID PAUL

    Inventor： HUMPHREYS DAVID PAUL

    IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46

    CPC classification number: C07K16/00 ,  C07K2317/55 ,  C07K2317/94

    Abstract: Disulfide Stabilised Antibodies and Fragments Thereof The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.

    Abstract translation: 二硫化物稳定的抗体及其片段本公开提供了包含至少一个Fab分子的抗体或抗体片段，其中Fab分子的轻链可变区，VL和重链区VH通过一个或多个二硫键连接， 并将其用于治疗或预防。

    MULTIVALENT ANTIBODIES
    6.
    发明申请
    MULTIVALENT ANTIBODIES 审中-公开
    多功能抗体

    公开(公告)号：WO2011061492A2

    公开(公告)日：2011-05-26

    申请号：PCT/GB2010002120

    申请日：2010-11-17

    Applicant: UCB PHARMA SA ,  HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  LAWSON ALASTAIR DAVID GRIFFITHS

    Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  LAWSON ALASTAIR DAVID GRIFFITHS

    IPC: C07K16/00

    CPC classification number: C07K16/00 ,  A61K47/60 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/624

    Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.

    Abstract translation: 一种多价抗体融合蛋白，其包含：重链，其从N末端依次包含名义上为VH1的可变结构域，CH1区域和名义上为VH2的另外的可变区，轻链，其从N末端依次包含， 可变结构域名义上为VL1，CL结构域和名义上为VL2的可变结构域，其中所述重链和轻链对齐以提供由第一可变结构域对VH1和VL1形成的第一结合位点和由第二结合位点形成的第二结合位点 VH2和VL2的可变结构域对，其中在形成结合位点的可变结构域对之间存在二硫键，并且所述融合蛋白与PEG聚合物缀合。

    BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC
    7.
    发明专利
    BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC 未知

    公开(公告)号：SG10201807560XA

    公开(公告)日：2018-10-30

    申请号：SG10201807560X

    申请日：2012-07-13

    Applicant: UCB PHARMA SA

    Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

    Abstract: BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC The present invention provides a recombinant gram-negative bacterial cell comprising and expression vector comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.

    Sequence symmetric modified lgG4 bispecific antibodies
    9.
    发明专利
    Sequence symmetric modified lgG4 bispecific antibodies 未知

    公开(公告)号：AU2013224004B2

    公开(公告)日：2017-11-23

    申请号：AU2013224004

    申请日：2013-02-22

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterised in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation.

    cepa hospedeira bacteriana que expressa dsbc recombinante
    10.
    发明专利
    cepa hospedeira bacteriana que expressa dsbc recombinante 未知

    公开(公告)号：BR112013032871A2

    公开(公告)日：2017-01-24

    申请号：BR112013032871

    申请日：2012-07-13

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  ELLIS MARK

    IPC: C07K16/28 ,  C12N15/70

    Abstract: 1/1 resumo “cepa hospedeira bacteriana que expressa dsbc recombinante” a presente invenção fornece uma célula bacteriana gram-negativa recombinante que compreende um vetor de expressão que compreende um polinucleotídeo recombinante que codifica dsbc e um ou mais polinucleotídeos que codificam um anticorpo ou um fragmento de ligação de antígeno deste que liga-se especificamente a cd154.

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