公开(公告)号：WO1996019938A1

公开(公告)日：1996-07-04

申请号：PCT/US1995016952

申请日：1995-12-22

Applicant: RTD TECHNOLOGY, INC.

Inventor： RTD TECHNOLOGY, INC. ,  SMITH, Richard, P. ,  COLE, Ned, M., Jr. ,  WHITAKER, Roger, B. ,  ANDREWS, Dale, R.

IPC: A61B05/00

CPC classification number: G01K7/42

Abstract: A quick registering thermometer (34) utilizing a sensor (50) that has electrical resistance varying with temperature and that is located at the tip (37) of a probe (36), the sensor (50) having a relatively small thermal mass and a short thermal time constant. Within seconds of contact with the patient, the circuitry (40) communicating with the sensor (50) determines the rate of change in resistance of the sensor (50) and, in turn, the temperature that the sensor (50) would reach if allowed the length of time it would need to reach equilibrium with the contact surface of the patient. Based on the equilibrium temperature determined for the surface of the patient, the circuitry (40) calculates and registers the core body temperature.

Abstract translation: 一种使用具有随温度变化的电阻并且位于探头（36）的尖端（37）处的传感器（50）的快速记录温度计（34），所述传感器（50）具有相对较小的热质量和 短热时间常数。 在与患者接触的几秒钟内，与传感器（50）通信的电路（40）确定传感器（50）的电阻变化率，反过来又确定传感器（50）在允许时达到的温度 需要与患者的接触表面达到平衡的时间长度。 基于为患者表面确定的平衡温度，电路（40）计算并记录核心体温。

公开(公告)号：WO1996017546A1

公开(公告)日：1996-06-13

申请号：PCT/US1995015567

申请日：1995-11-30

Applicant: OPTISCAN, INC.

Inventor： OPTISCAN, INC. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  STERLING, Bernhard, B.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/35 ,  G01N21/3581

Abstract: This invention is a method and apparatus for monitoring glucose, ethyl alcohol, and other blood constituents in a noninvasive manner. Long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood is measured (114) at characteristic infrared absorption wavelengths (110) for those constituents. The measurements are preferably synchronized (124) with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues may be cancelled when a ratio of the detected signals is taken. If no synchronization is provided, the spectrophotometer may measure the arterial, venous, and tissue constituent concentrations simultaneously. The internal "blackbody" energy level of an infrared emissions source such as a vascularized appendage is measured (300) and used to compensate temperature dependent effects in the concentration calculation. The internal energy level ratio is ratioed to the actual measured energy.

Abstract translation: 本发明是以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 监测由人发射的长波长的红外线能量，并且对于这些组分，在特征红外吸收波长（110）测量血液中特定组分的红外吸收（114）。 所述测量优选地与心动周期的心律和舒张同步（124），使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献。 如果没有提供同步，分光光度计可以同时测量动脉，静脉和组织成分浓度。 测量（300）红外发射源（如血管附着物）的内部“黑体”能级，用于补偿浓度计算中的温度依赖性影响。 内部能量比率与实际测量的能量相比。

公开(公告)号：WO1996016592A1

公开(公告)日：1996-06-06

申请号：PCT/US1995015666

申请日：1995-12-04

Applicant: NON-INVASIVE TECHNOLOGY, INC. ,  CHANCE, Britton ,  LIU, Hanli

Inventor： NON-INVASIVE TECHNOLOGY, INC.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/6824 ,  A61B5/7257

Abstract: This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light (16, 18, 20), the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

Abstract translation: 本发明是用于监测生物系统中的溶质的方案，包括以下步骤：将光输送到含有溶质的生物系统（12）中，所述光的波长选择在其中溶质基本上不吸收的范围内; 检测所传送的光（16,18,20）的至少第一和第二部分，所述第一部分沿着一个或多个路径行进，所述路径的特征在于第一平均路径长度，并且所述第二部分已经穿过所述生物 系统沿着一个或多个路径，其特征在于大于第一平均路径长度的第二平均路径长度; 以及比较所输送的光的第一和第二部分以监测生物系统中溶质的浓度。 还描述了用于监测低分子量多羟基溶质，通常为糖（甘露醇，果糖，蔗糖，葡萄糖，山梨糖醇），醇（甲醇，乙醇，丙二醇）和电解质（钠，钾，镁，钙和氯离子） 。

公开(公告)号：WO1996004840A1

公开(公告)日：1996-02-22

申请号：PCT/GB1995001944

申请日：1995-08-16

Applicant: PARKER, Dawood

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: A device for the non-invasive measurement of the concentration of a specific analyte, particularly glucose, in arterial blood flowing in a patient's body part (10), which device comprises a first portion having a surface profile adapted to be held against the selected body part, a source (11) of near infrared radiation mounted in a second portion associated with said first portion such that near infrared radiation is transmitted through or reflected from said body part, a third portion containing a detector (15) and filters (14) to receive radiation transmitted through or reflected from said body part, to select signals generated by the pulsatile component of the absorption spectrum and to provide a ratio representative of the desired concentration. A method for the determination of glucose concentration in arterial blood is also disclosed.

Abstract translation: 一种用于非侵入性地测量在患者体部（10）中流动的动脉血中特定分析物（特别是葡萄糖）浓度的装置，该装置包括具有适于保持抵靠所选体的表面轮廓的第一部分 部分，安装在与所述第一部分相关联的第二部分中的近红外辐射源（11），使得近红外辐射透过所述主体部分或从所述主体部分反射，第三部分包含检测器（15）和过滤器（14） 以接收通过所述身体部分透射或反射的辐射，以选择由吸收光谱的脉动分量产生的信号，并提供表示期望浓度的比率。 还公开了确定动脉血中葡萄糖浓度的方法。

公开(公告)号：WO1995029629A1

公开(公告)日：1995-11-09

申请号：PCT/IB1995000184

申请日：1995-03-20

Applicant: BIOMEDICAL SENSORS, LTD.

Inventor： BIOMEDICAL SENSORS, LTD. ,  SINGER, Mervyn

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/1473 ,  A61B5/6853 ,  A61B5/6855 ,  A61M25/10

Abstract: An apparatus for the determination and continuous monitoring of bladder epithelial oxygen (pb02) which comprises, in combination, an introductory catheter (1) with an inflatable placement cuff (4) and an oxygen sensor, wherein the sensor is completely accommodated within the catheter (1) when not in use and, when the apparatus is placed within a patient's bladder, the sensor is adapted to be deployed so that the distal end (7) of the sensor passes through an open port (3) in the distal wall of the catheter (1) and extends beyond the tip (2) of the catheter (1) to rest against the wall of the bladder; and a method for the continuous monitoring of pb02 using such apparatus.

Abstract translation: 一种用于确定和连续监测膀胱上皮氧（pb02）的装置，其组合包括具有可充气放置袖带（4）和氧传感器的导入导管（1），其中所述传感器完全容纳在导管内 1）当不使用时，并且当将装置放置在患者的膀胱内时，传感器适于被展开，使得传感器的远端（7）穿过位于病人膀胱的远侧壁中的开口（3） 导管（1）并延伸超过导管（1）的尖端（2）以抵靠膀胱的壁; 以及使用这样的装置连续监测pb02的方法。

公开(公告)号：WO1995022279A1

公开(公告)日：1995-08-24

申请号：PCT/US1994001918

申请日：1994-02-16

Applicant: ZILA PHARMACEUTICALS, INC. ,  HINES, Joseph

Inventor： ZILA PHARMACEUTICALS, INC.

IPC: A61B05/00

CPC classification number: A61B5/0077 ,  A61B5/0088 ,  G06F19/00 ,  G16H10/60 ,  G16H15/00

Abstract: A method for detecting epithelial cancer includes generating a real-time video image of the locus of potential cancerous sites on the epithelium. The real-time video image is displayed on a television monitor screen. The real-time video image on the monitor is examined to locate suspected cancerous sites and the results of such examination are recorded.

Abstract translation: 用于检测上皮癌的方法包括产生上皮上的潜在癌性位点的轨迹的实时视频图像。 实时视频图像显示在电视监视器屏幕上。 检查监视器上的实时视频图像以查找可疑的癌症位点，并记录此类检查的结果。

公开(公告)号：WO1995020906A1

公开(公告)日：1995-08-10

申请号：PCT/US1995000384

申请日：1995-01-12

Applicant: FUTREX, INC.

Inventor： FUTREX, INC. ,  ROSENTHAL, Robert, D.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: A procedure for verifying the accuracy of a non-invasive blood glucose measurement instrument (10) utilizes in vitro or invasive measurement instruments (100), the accuracy of which is independently verifiable. Several glucose readings are taken with each instrument at approximately the same times. The measurement data from the in vitro instrument (100) is transferred to the non-invasive instrument (10) where it is compared to the data regarding the non-invasive measurements. If the difference between the measurements of the respective instruments is within a preset range, the non-invasive instrument is permitted to be used for an additional period of time. However, if the difference is beyond an acceptable limit, then the non-invasive instrument is prevented from taking any additional measurements and must be serviced or repaired.

Abstract translation: 用于验证非侵入性血糖测量仪器（10）的准确性的程序利用体外或侵入性测量仪器（100），其精度可独立验证。 在几乎相同的时间，每台仪器都会获取几个葡萄糖读数。 来自体外仪器（100）的测量数据被转移到非侵入性仪器（10），在那里将其与关于非侵入性测量的数据进行比较。 如果各个仪器的测量值之间的差异在预设范围内，则允许非侵入性仪器在另外一段时间内使用。 然而，如果差异超出了可接受的限度，那么防止非侵入性仪器进行任何额外的测量，并且必须进行维修或维修。

公开(公告)号：WO1995020343A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001006

申请日：1995-01-27

Applicant: SCHNEIDER MEDICAL TECHNOLOGIES, INC.

Inventor： SCHNEIDER MEDICAL TECHNOLOGIES, INC. ,  SCHNEIDER, M., Bret

IPC: A61B05/00

CPC classification number: G06F19/321 ,  A61B90/10 ,  A61B90/36 ,  A61B2090/374 ,  A61B2090/378 ,  G06F19/00

Abstract: This invention is a method and apparatus (2) for obtaining and displaying in real time an image of an object (10) obtained by one modality such that the image corresponds to a line of view established by another modality. The method comprises steps of obtaining a follow image library (14) of the object via a first imaging modality; providing a lead image library (12) obtained via the second imaging modality; referencing the lead image libray to the follow image library; obtaining a lead image of the object in real time via the second imaging modality along a lead view; comparing the real time lead image to lead images in the lead image library via digital image analysis to identify a follow image line of view corresponding to the real time lead view; transforming the identified follow image to correspond to the scale, rotation, and position of the lead image; and displaying the transformed follow image.

Abstract translation: 本发明是一种用于实时获取和显示通过一种模式获得的对象（10）的图像的方法和装置（2），使得图像对应于由另一模态建立的视线。 该方法包括以下步骤：经由第一成像模式获得对象的跟随图像库（14）; 提供通过第二成像模式获得的引导图像库（12）; 将引导图像库引用到跟踪图像库中; 沿着引导视图经由第二成像模式实时获取对象的引导图像; 通过数字图像分析比较实时引导图像和引导图像库中的图像，以识别与实时引导视图对应的跟随图像线; 将所识别的跟踪图像变换为对应于铅图像的缩放，旋转和位置; 并显示变换后的图像。

公开(公告)号：WO1995016388A1

公开(公告)日：1995-06-22

申请号：PCT/US1994013586

申请日：1994-11-22

Applicant: NELLCOR INCORPORATED

Inventor： NELLCOR INCORPORATED ,  MERCHANT, Adnan, I. ,  BERNSTEIN, Michael

IPC: A61B05/00

CPC classification number: A61B5/14551 ,  A61B5/0017

Abstract: The present invention provides a medical sensor for detecting a blood characteristic. The sensor includes a transducer for producing an analog signal related to the blood characteristic. The analog signal is converted into a transmission signal which is in amplitude-independent form for transmission to a remote analyzer. In one embodiment, a current-to-frequency converter converts a signal from a pulse oximeter sensor into a frequency signal which can be transmitted over a transmission line to a remote pulse oximeter.

Abstract translation: 本发明提供一种用于检测血液特性的医疗传感器。 传感器包括用于产生与血液特性相关的模拟信号的换能器。 模拟信号被转换为与振幅无关的传输信号，用于传输到远程分析仪。 在一个实施例中，电流 - 频率转换器将来自脉搏血氧计传感器的信号转换成可以通过传输线传输到远程脉搏血氧计的频率信号。

公开(公告)号：WO1995016387A1

公开(公告)日：1995-06-22

申请号：PCT/US1994013497

申请日：1994-11-22

Applicant: NELLCOR INCORPORATED

Inventor： NELLCOR INCORPORATED ,  FEIN, Michael E. ,  JENKINS, David C. ,  BERNSTEIN, Michael, J. ,  VENKATACHALAM, K., L. ,  MERCHANT, Adnan, I. ,  BOWDEN, Charles, H.

IPC: A61B05/00

CPC classification number: A61B5/14551 ,  A61B5/0002 ,  A61B5/7228 ,  A61B2562/08

Abstract: The present invention provides an encoding mechanism for a medical sensor which uses a modulated signal to provide the coded data to a remote analyser. The modulated signal could be, for instance, a pulse width modulated signal or a frequency modulated signal. This signal is amplitude independent and thus provides a significant amount of noise immunity.

Abstract translation: 本发明提供了一种用于医疗传感器的编码机构，其使用调制信号将编码数据提供给远程分析器。 调制信号可以是例如脉冲宽度调制信号或调频信号。 该信号是幅度无关的，因此提供了大量的抗噪声能力。