公开(公告)号：WO1996017546A1

公开(公告)日：1996-06-13

申请号：PCT/US1995015567

申请日：1995-11-30

Applicant: OPTISCAN, INC.

Inventor： OPTISCAN, INC. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  STERLING, Bernhard, B.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/35 ,  G01N21/3581

Abstract: This invention is a method and apparatus for monitoring glucose, ethyl alcohol, and other blood constituents in a noninvasive manner. Long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood is measured (114) at characteristic infrared absorption wavelengths (110) for those constituents. The measurements are preferably synchronized (124) with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues may be cancelled when a ratio of the detected signals is taken. If no synchronization is provided, the spectrophotometer may measure the arterial, venous, and tissue constituent concentrations simultaneously. The internal "blackbody" energy level of an infrared emissions source such as a vascularized appendage is measured (300) and used to compensate temperature dependent effects in the concentration calculation. The internal energy level ratio is ratioed to the actual measured energy.

Abstract translation: 本发明是以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 监测由人发射的长波长的红外线能量，并且对于这些组分，在特征红外吸收波长（110）测量血液中特定组分的红外吸收（114）。 所述测量优选地与心动周期的心律和舒张同步（124），使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献。 如果没有提供同步，分光光度计可以同时测量动脉，静脉和组织成分浓度。 测量（300）红外发射源（如血管附着物）的内部“黑体”能级，用于补偿浓度计算中的温度依赖性影响。 内部能量比率与实际测量的能量相比。

公开(公告)号：WO1995031930A1

公开(公告)日：1995-11-30

申请号：PCT/US1995006513

申请日：1995-05-22

Applicant: OPTISCAN, INC.

Inventor： OPTISCAN, INC. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  HERRERA, Roger, O. ,  STERLING, Bernhard, B.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6826 ,  G01N21/35 ,  G01N21/3581

Abstract: A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured by infrared detector (412) at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle monitored by cardiac monitor (718) so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled by microprocessor (418) when a ratio of the detected signals is taken. The concentration of the blood constituents is then determined in accordance with a polynomial equation.

Abstract translation: 一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。 监测由人发射的长波长的红外线能量，并通过红外检测器（412）以特征红外吸收波长测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。 优选地，所述测量与由心脏监测器（718）监测的心动周期的收缩和舒张同步，使得当静脉和组织（其不脉冲）引起的信号贡献可被微处理器（418）抵消，当检测到的 采取信号。 然后根据多项式方程确定血液成分的浓度。