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    141.
    发明专利
    未知

    公开(公告)号：AT398035B

    公开(公告)日：1994-08-25

    申请号：AT114389

    申请日：1989-05-12

    Applicant: GLAXO INC

    IPC: A61K9/30 ,  A61K9/28 ,  A61K9/36 ,  A61K31/34 ,  A61K47/14 ,  A61K47/30 ,  A61K47/38 ,  A61P43/00

    Abstract: This invention relates to an improved polymeric film coating for a ranitidine Hydrocholride (HCl) tablet in which the plasticizer triacetin had been added to the polymeric film coating medium. A tablet of this invention has been found to have great stability than a tablet coating with a polymeric film which does not contain triacetin.

    1, 5-benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
    144.
    发明专利
    1, 5-benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them 未知

    公开(公告)号：IL109315D0

    公开(公告)日：1994-07-31

    申请号：IL10931594

    申请日：1994-04-13

    Applicant: GLAXO INC

    IPC: A61K31/551 ,  A61K38/00 ,  A61K38/02 ,  A61P3/00 ,  A61P5/00 ,  A61P43/00 ,  C07D243/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/097 ,  C07D

    Abstract: PCT No. PCT/EP94/01130 Sec. 371 Date Oct. 30, 1995 Sec. 102(e) Date Oct. 30, 1995 PCT Filed Apr. 13, 1994 PCT Pub. No. WO94/24151 PCT Pub. Date Oct. 27, 1994The present invention relates to compounds of general formula (I) (I) and physiologically acceptable salts thereof wherein the group NR1R2 represents a 5-7 membered saturated heterocyclic ring which may be substituted by one or two methyl groups; R3 is C1-6alkyl, C3-6cycloalkyl or phenyl optionally substituted by 1 or 2 halogen atoms; R4 is phenyl or phenyl substituted by one or two groups selected from the group consisting of halogen, C1-4alkyl, trifluoromethyl, trifluoromethoxy or (CH2)nR5 wherein n is zero or 1 and R5 represents C1-4alkoxy, hydroxy, nitro, cyano, CO2R6, S(O)pCH3, NR7R8, CONR7R8, SO2NR7CO(C1-4)alkyl, tetrazolyl, carboxamidotetrazolyl, or a 3-trifluoromethyl 1,2,4-triazolyl; R6 is hydrogen, C1-4alkyl or benzyl; R7 is hydrogen or C1-4alkyl, R8 is hydrogen, C1-4alkyl, SO2CH3 or SO2CF3, X represent hydrogen, C1-4alkyl or halogen; m is zero, 1 or 2, and p is zero, 1 or 2. The invention also relates to processes for preparation of these compounds and to their use in medicine as antagonists of gastrin and CCK.

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