公开(公告)号：ZA9308385B

公开(公告)日：1994-08-09

申请号：ZA9308385

申请日：1993-11-10

Applicant: GLAXO INC

Inventor： LACKEY KAREN ,  LUZZIO MICHAEL JOSEPH ,  EVANS MICHAEL GLENN ,  BESTERMAN JEFFREY MARK ,  STERNBACH DANIEL DAVID ,  PEEL MICHAEL ROBERT

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

公开(公告)号：SI9300591A

公开(公告)日：1994-06-30

申请号：SI9300591

申请日：1993-11-11

Applicant: GLAXO INC

Inventor： LACKEY KAREN ,  LUZZIO MICHAEL JOSEPH ,  EVANS MICHAEL GLENN ,  BESTERMAN JEFFREY MARK ,  STERNBACH DANIEL DAVID ,  PEEL MICHAEL ROBERT

IPC: A61K31/47 ,  A61K31/675 ,  A61P35/00 ,  A61P43/00 ,  C07D317/66 ,  C07D319/18 ,  C07D491/22 ,  C07F9/6561 ,  A61K31/435

Abstract: The present invention relates to water soluble, camptothecin derivatives of formula (I). wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): X is selected from the group consisting of alkyl, aryl, (CH2)mOR1, (CH2)mSR1 and (CH2)mNR1R2 wherein m is an integer of 0 to 6, and R1 and R2 are hydrogen, lower alkyl, aryl or together with the nitrogen form a 5-7 membered ring; q is an integer of 0 to 2; n represents the integer 1 or 2; p is an integer of 1 to 6; Y and W are selected from the group consisting of alkyl, aryl, alkoxy, aryloxy and amino, Q is oxygen or sulfur; P is phosphorus; J represents the atoms necessary to complete a 5 or 6 membered aromatic ring; and the pharmaceutically acceptable salts thereof; their use as topoisomerase inhibitors, their preparation; and their use in the treatment of cancer.

公开(公告)号：ZA938385B

公开(公告)日：1994-08-09

申请号：ZA938385

申请日：1993-11-10

Applicant: GLAXO INC

Inventor： LACKEY KAREN ,  LUZZIO MICHAEL JOSEPH ,  EVANS MICHAEL GLENN ,  BESTERMAN JEFFREY MARK ,  STERNBACH DANIEL DAVID ,  PEEL MICHAEL ROBERT

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

公开(公告)号：MX9307011A

公开(公告)日：1994-05-31

申请号：MX9307011

申请日：1993-11-10

Applicant: GLAXO INC

Inventor： BESTERMAN JEFFREY MARK ,  STERNBACH DANIEL DAVID ,  PEEL MICHAEL ROBERT ,  LACKEY KAREN ,  LUZZIO MICHAEL JOSEPH ,  EVANS MICHAEL GLENN

IPC: A61K31/47 ,  A61K31/675 ,  A61P35/00 ,  A61P43/00 ,  C07D317/66 ,  C07D319/18 ,  C07D491/22 ,  C07F9/6561

Abstract: The present invention relates to water soluble, camptothecin derivatives of formula (I). wherein A represents a moiety of the formula (IIA), (IIB) or (IIC): X is selected from the group consisting of alkyl, aryl, (CH2)mOR1, (CH2)mSR1 and (CH2)mNR1R2 wherein m is an integer of 0 to 6, and R1 and R2 are hydrogen, lower alkyl, aryl or together with the nitrogen form a 5-7 membered ring; q is an integer of 0 to 2; n represents the integer 1 or 2; p is an integer of 1 to 6; Y and W are selected from the group consisting of alkyl, aryl, alkoxy, aryloxy and amino, Q is oxygen or sulfur; P is phosphorus; J represents the atoms necessary to complete a 5 or 6 membered aromatic ring; and the pharmaceutically acceptable salts thereof; their use as topoisomerase inhibitors, their preparation; and their use in the treatment of cancer.

公开(公告)号：IS4092A

公开(公告)日：1994-05-13

申请号：IS4092

申请日：1993-11-08

Applicant: GLAXO INC

Inventor： LACKEY KAREN ,  LUZZIO MICHAEL JOSEPH ,  EVANS MICHAEL GLENN ,  BESTERMAN JEFFREY MARK ,  STERNBACH DANIEL DAVID ,  PEEL MICHAEL ROBERT

IPC: A61K31/47 ,  A61K31/675 ,  A61P35/00 ,  A61P43/00 ,  C07D317/66 ,  C07D319/18 ,  C07D491/22 ,  C07F9/6561