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141.发明专利Manufacture of composition containing therapeutically or immunologically active protein 失效含有治疗或免疫活性蛋白的组合物的制备
公开(公告)号：JPS59193830A
公开(公告)日：1984-11-02
申请号：JP5852284
申请日：1984-03-28
Applicant: Miles Lab
Inventor： KENESU JIEI RENBATSUKU
IPC: A61K39/00 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , A61K38/22 , A61K38/27 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/108 , A61K39/145 , A61K39/245 , A61K39/285 , A61K39/395 , A61L2/00
CPC classification number: A61L2/0088 , A61K31/14 , A61K35/14 , A61K35/16 , A61K38/00 , A61K39/00 , A61L2/0023 , A61L2/04 , A61L2/18 , Y10S514/802 , Y10S530/806 , Y10S530/825 , Y10S530/826
Abstract: Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein composition with a complex formed from source of transition metal ions, such as copper ions, and an angularly-fused, polynuclear heterocyclic arene having two nitrogen atoms in a "cis-ortho" relationship, such as phenanthroline, and a reducing agent such as a thiol in amounts and at a temperature and for a time sufficient to inactivate substantially all of the viruses and bacteria contained therein. Compositions containing therapeutically active proteins substantially free from viral and bacterial infectivity, which have heretofore been unattainable, can be prepared by the method of the invention.
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142.发明专利Test composition for measuring peroxide activation substance, testing tool and method of using these tool and manufacturing them 失效用于测量过氧化物活化物质的测试组合物，测试工具以及使用这些工具和制造它们的方法
公开(公告)号：JPS59190663A
公开(公告)日：1984-10-29
申请号：JP6528984
申请日：1984-04-03
Applicant: Miles Lab
Inventor： MEARII RUU GANTSUAA
CPC classification number: C12Q1/28 , G01N33/725 , Y10S436/904
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143.发明专利
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公开(公告)号：JPS59175468A
公开(公告)日：1984-10-04
申请号：JP4572284
申请日：1984-03-12
Applicant: Miles Lab
Inventor： ROBAATO TEII BATSUKURAA , ROBAATO PII HATSUCHI
IPC: C07D215/38 , C07C67/00 , C07C227/00 , C07C229/44 , C07D215/36 , C07D215/54 , C07D311/16 , C07D311/20 , C12Q1/28 , G01N31/00 , G01N31/22
CPC classification number: C07D215/54 , C07D311/20 , C12Q1/28 , C12Q2326/00
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145.发明专利Tricyclic anti-melancholia agent immunogen, antibody, markedcomposite body and related derivative and reagent using these substance, test kit, testing tool and immunity test method 失效TRICYCLIC抗美沙酮代理商免疫，抗体，标记物和相关衍生物和试剂，使用这些物质，测试包，测试工具和免疫测试方法
公开(公告)号：JPS59132362A
公开(公告)日：1984-07-30
申请号：JP19537783
申请日：1983-10-20
Applicant: Miles Lab
IPC: G01N33/53 , C07D223/22 , C07D303/14 , C07D405/06 , C07H17/075 , C07H21/00 , C07K14/435 , C07K14/76 , C07K16/00 , G01N33/532 , G01N33/94
CPC classification number: C07D405/06 , C07D223/22 , C07D303/14 , C07H17/075 , C07H21/00 , G01N33/532 , G01N33/9466 , Y10S435/961 , Y10S435/975 , Y10S436/815 , Y10S530/806
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Patent Agency Ranking
公开(公告)号：JPS59130187A
公开(公告)日：1984-07-26
申请号：JP20292983
申请日：1983-10-31
Applicant: Miles Lab
Inventor： JIYOSEFUIN GUROSHIYU , GEERII EI UIRUSON , KAREN UORUUEBAA , KURIFUOODO OO IEERU
IPC: C12N15/09 , C12N1/20 , C12N9/28 , C12N9/34 , C12N9/54 , C12N9/92 , C12N15/00 , C12N15/64 , C12N15/75 , C12Q1/04 , C12Q1/40 , C12R1/07
CPC classification number: C12N9/2417 , C12N9/2428 , C12N9/54 , C12N9/92 , C12N15/64 , C12N15/75 , C12Q1/40
Abstract: A method for heterologous cloning of a gene encoding alpha -amylase, protease, amyloglucosidase or glucose isomerase. The method involves the use of a bifunctional plasmid which can replicate in both E. coli and B. subtilis, and contains at least two selectable markers. A gene fragment for the enzyme is incorporated into the plasmid, leaving at least one functional selectable marker and a nonfunctional marker, producing a mixture of recombinant hybrid plasmids and the original bifunctional plasmid. This mixture is incorporated into E. coli microorganisms and transformants selected. The transformants which contain the recombinant plasmid are identified, and plasmid DNA extracted. The plasmid DNA is used to transform Bacillus host microorganisms and transformants containing the recombinant plasmids are selected by means of the functional selectable marker.
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公开(公告)号：JPS5983056A
公开(公告)日：1984-05-14
申请号：JP17444283
申请日：1983-09-22
Applicant: MILES LAB
Inventor： JIEEMUZU POORU ARUBARERA
IPC: G01N33/53 , C07J41/00 , C07K14/435 , C07K14/76 , C07K16/00 , G01N33/531 , G01N33/94
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公开(公告)号：JPS5951351A
公开(公告)日：1984-03-24
申请号：JP22405282
申请日：1982-12-22
Applicant: Miles Lab
Inventor： ERIZABESU KASUTAADO , JIYON SHII RIYOU , JIYON ERU PONZO
CPC classification number: G01N1/30
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公开(公告)号：JPS5944322A
公开(公告)日：1984-03-12
申请号：JP14125683
申请日：1983-08-03
Applicant: Miles Lab
Inventor： SUTEIIBUN AI CHIYABIN , FUIRITSUPU JIEI FUEI
IPC: A61K35/14 , A61K38/00 , A61K38/43 , C07K14/755
CPC classification number: C07K14/755 , A61K38/00 , Y10S530/83
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150.发明专利
公开(公告)号：JPS5942454A
公开(公告)日：1984-03-09
申请号：JP12246483
申请日：1983-07-07
Applicant: Miles Lab
IPC: G01N33/542 , C07D209/48 , C07D237/32 , C07D493/10 , C07D495/04 , C07H19/20 , C07H19/207 , C07H21/00 , C12Q1/00 , G01N31/00 , G01N33/50 , G01N33/532 , G01N33/533 , G01N33/536 , G01N33/543 , G01N33/60
CPC classification number: C07D209/48 , C07D237/32 , C07D493/10 , C07D495/04 , C07H21/00 , G01N33/533
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